Abstract of Sex-Selective Effects of Early Life Stress on the Development of Cognitive and Affective Pathology in a Mouse Model, by Haley Goodwill, Ph.D., Brown …
Alterations in metabolism, sleep patterns, body composition, and hormone status are all key features of aging. While the hypothalamus is a well-conserved brain region that …
Opiate abuse is a major health concern and economic burden on society with overdose deaths rising dramatically in the past decade. Synaptic plasticity within the …
Abstract of The Cells and Molecules Underlying Mechanosensation, by Ruby Minh Lam, Ph.D., Brown University, May 2024. The somatosensory system provides us with a window …
The immune dysfunction induced by alcohol use has severe and devastating health consequences. Despite extensive research characterizing the widespread effects of alcohol consumption on the …
The neuromuscular junction (NMJ) is required for muscle excitation, and its dysfunction is thought to contribute to deficits observed in sarcopenia and neuromuscular disease. The …
Alcohol Use Disorder (AUD) is a chronic relapsing disease that has a major public health impact. The neurobiology of AUD remains poorly understood, and pharmacotherapies …
Top-down signals such as attention not only modulate an individual neuron’s activity, but also orchestrate the synchrony in sensory areas. For example, spatial attention selectively …
Everyday tasks often require to be completed following a specific set of steps or sequentially. Oftentimes, these sequential tasks are abstract, meaning that they are …
As we move throughout the world, our brains continuously acquire sensory information and make predictions when visual information is limited. For example, an animal hopping …
Recessive loss-of-function mutations in the mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) in humans cause reduced postnatal brain growth, and cognitive and motor disability. GPT2 …
The visual system takes information from a handful of photoreceptor types and, using a complex circuitry of neurons, transforms that information into a wide range …
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention and hyperactivity/impulsivity. While ADHD has a high degree of heritability, how rare genetic …
The human brain's intricate machinery relies on the seamless function of its neurons throughout the organism’s lifetime. However, when faced with genetic mutations or environmental …
Abstract of “Ventral Tegmental Area Regulation of Dynamic Blood-Brain Barrier Permeability” by Sinda Fekir, Ph.D., Brown University, May 2024 The ability to optimize behavior depends …
It has been established that the feed-forward sweep along the ventral visual pathway is crucial for core object recognition. However, the visual system contains abundant …
To engage with the world, we must regularly make predictions about the outcomes of scenarios. How do we make these predictions? Recent evidence points to …
Implantable brain-computer interface (BCI) systems may one day offer persons with locked-in syndrome a means of interacting and communicating with the outside world. These systems …
Voltage-gated calcium channels in neurons couple membrane depolarization to calcium-dependent processes, including activity-dependent gene expression and synaptic neurotransmitter release. In nociceptors, CaV2.2 channels are the …
In the mouse olfactory bulb glomerular layer, computations are largely mediated by a set of interneurons, known as the periglomerular cells (PGCs). I hypothesized that …
