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Items (61-80) out of 209 results

Errata for “Phylogenetic and Phenotypic Studies of the Extremophile Chroococcidiopsis (Cyanobacterium): A Foundation for Synthetic Biology in Space”

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Description:: Errata for “Phylogenetic and Phenotypic Studies of the Extremophile Chroococcidiopsis (Cyanobacterium): A Foundation for Synthetic Biology in Space” originally published May 2012 by John R. …
Year:: 2023
Contributor:: Cumbers, John R. (Author)
Subject:: Space; Cyanobacterium; Extremophile Chroococcidiopsis; Space Synthetic Biology; Synthetic Biology
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Establishing a Functional Link between Metabolic Regulation and Early Embryonic Cell Specification in Strongylocentrotus purpuratus

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Description:: It has been known that early embryos are largely dependent on the Warburg Effect – a glycolysis-dependent metabolism – for energy. Yet, recent studies in …
Year:: 2022
Contributor:: Rajachandran, Shreya (creator); Yajima, Mamiko (thesis advisor); Plavicki, Jessica (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Sea urchins--Embryos; Metabolism; Wnt pathway
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

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Estrogen Mediated Coordination of Post-Transcriptional Regulation

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Description:: The aim of this body of research is to gain a more complete understanding of how 17β-estradiol (E2) drives the proliferation of breast cancer. This …
Year:: 2011
Contributor:: Bronson, Michael W (creator); Brodsky, Alexander (Director); Reenan, Robert (Reader); Gerbi, Susan (Reader); William, Fairbrother (Reader); Lupien, Mathieu (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: 17β-estradiol; breast cancer; gene; gene regulation; polysome; post-transcriptional; transcriptional; transcriptome; translation; MCF-7; microarray; mRNA; SRY (sex determining region Y) box 2 (SOX2); neuron-restrictive silencer factor (NRSF); hormone action; endocrine therapy; expression signatures; transcription factors; Estrogen; Breast--Cancer; Genetics; Genetic regulation; Transcription; RNA; Messenger RNA; Cell cycle; Tamoxifen; Hormone therapy; Transcription factors
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Evolutionary transitions within Echinodermata

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Description:: Echinodermata is a very rich group of organisms which is comprised of sea urchins, sea stars, brittle stars, sea lilies and sea cucumbers, and as …
Year:: 2014
Contributor:: Reich, Adrian (creator); Wessel, Gary (Director); Dunn, Casey (Reader); Johnson, Mark (Reader); Mowry, Kimberly (Reader); Cameron, Andrew (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Echinoderms; transcriptome; Echinodermata; Developmental biology; Phylogeny
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Expression and function of extraocular opsin 3 in mammalian skin and brain

Description:: The mammalian opsin family of light-sensitive G protein-coupled receptors (GPCRs) includes retinal pigments like rhodopsin (OPN2) and cone opsins (OPN1), which mediate vision, as well …
Year:: 2020
Contributor:: Olinski, Lauren (creator); Creton, Robbert (Reader); Freiman, Richard (Reader); Connors, Barry (Reader); Oancea, Elena (Advisor); Hattar, Samer (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Skin; Opsin; Hypothalamus; OPN3; Melanocortin
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Fighting Infections: The Role of Estrogen Beyond Reproductive Health

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Description:: Estrogen, the major female sex hormone has been linked with immune response disparity between males and females. However, the exact mechanism by which estrogen impacts …
Year:: 2024
Contributor:: Mithila, Farha Jesmin (creator); Beura, Lalit (Advisor); Freiman, Richard (Reader); Brossay, Laurent (Reader); Larschan, Erica (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: mucosal immunity; antiviral immune response; Estrogen
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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FMRP Regulates the Expression of Axonal Messages In Vivo

Description:: Fragile X syndrome, a leading cause of autism and the most common form of inherited intellectual disability, results from the loss of Fragile X mental …
Year:: 2013
Contributor:: Berk-Rauch, Hanna E (creator); Fallon, Justin (Director); Freiman, Richard (Reader); Mowry, Kimberly (Reader); Barnea, Gilad (Reader); Darnell, Jennifer (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: cellular biology; Neurosciences; Cytology; Molecular biology
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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From Cargo to Cues: Unveiling Germline Formation in Echinoderms

Description:: Germline continuity ensures the survival of sexually reproducing species by enabling the transmission of genetic material to the next generation. The formation of primordial germ …
Year:: 2025
Contributor:: Reyes, Gerardo Luis (creator); Wessel, Gary (Advisor); Lisi, George (Reader); Larschan, Erica (Reader); Fairbrother, William (Reader); Seaver, Elaine (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Echinodermata; Extracellular matrix; RNA splicing; Germ cells--Differentiation--Regulation; Blimp1
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Functional Analysis of HAP2 Reveals Insights into a Gamete Fusion Mechanism

Description:: Gamete fusion is an essential step in sexual reproduction, requiring the merger of plasma membranes and genetic material from two gametes to produce a single …
Year:: 2018
Contributor:: Forcina, Jennifer (creator); Johnson, Mark (Advisor); DeLong, Alison (Reader); Wessel, Gary (Reader); Fawzi, Nicolas (Reader); Kielian, Margaret (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Fertilization; Gamete fusion; Plants--Reproduction
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Functional and Structural Studies of the MuSK-BMP Pathway

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Description:: Maintenance of muscle is important in many aspects from aging to spaceflight. Loss of muscle and strength occurs as humans age and placing them at …
Year:: 2021
Contributor:: Jaime, Diego (creator); Fallon, Justin (Advisor); Jaworski, Alexander (Reader); Wharton, Kristi (Reader); Barnea, Gilad (Reader); Lee, Se-Jin (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: BMP signaling; MuSK; muscle; Muscular atrophy
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Functional characterization of ALS models in Drosophila: disrupted sensory feedback preceding motor neuron degeneration is rescued by BMP signaling

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Description:: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive, rapid loss of motor function. Within 3-5 years, a loss of motor function …
Year:: 2018
Contributor:: Held, Aaron Harry (creator); Wharton, Kristi (Advisor); Lipscombe, Diane (Reader); Hart, Anne (Reader); Morrow, Eric (Reader); Serpe, Mihaela (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster; Amyotrophic lateral sclerosis; Neurodegeneration; BMP signaling; Motor Circuitry
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Functions and genetically induced dysfunctions of neural circuits in the thalamus

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Description:: Most sensory information destined for the neocortex is relayed there from the thalamus, where considerable transformation occurs. One powerful means of transformation involves interactions between …
Year:: 2019
Contributor:: Martinez-Garcia, Rosa I. (creator); Connors, Barry (Advisor); Berson, David (Reader); Lipscombe, Diane (Reader); Cruikshank, Scott (Reader); Zervas, Mark (Reader); Chen, Chinfei (Reader); Morrow, Eric (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Thalamus; Thalamic Reticular Nucleus; thalamocortical; Tsc1; mTOR; electrical synapses
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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GA-Binding Proteins Regulate Dosage Compensation in Drosophila Melanogaster

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Description:: Abstract of “GA-Binding Proteins Regulate Dosage Compensation in Drosophila melanogaster” by Emily Grace Kaye, Ph.D., Brown University, May 2018 A transcription factor (TF) will bind …
Year:: 2017
Contributor:: Kaye, Emily G. (creator); Freiman, Richard (Reader); Wharton, Kristi (Reader); Larschan, Erica (Advisor); Guertin, Michael (Reader); Fawzi, Nicolas (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Transcription factors; dosage compensation
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Gene Expression Changes Associated with the Differentiation of Mouse Embryonic Stem Cells to Primordial Germ Cell-Like Cells

Description:: Embryonic stem cells (ESCs) are found early in the developing embryo and from this initial population, all cells in the body are eventually derived. A …
Year:: 2018
Contributor:: Mori, Megumi (creator); Freiman, Richard (Advisor); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Cell differentiation; Molecular biology; pluripotency; Embryonic stem cells--Research; primordial germ cells
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Gene expression programs underlying spinal commissural neuron differentiation and midline axon guidance

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Description:: Nervous system development depends on the precise organization of a complex series of events. Many hundreds of distinct neuronal types must be generated in the …
Year:: 2024
Contributor:: Abolafia, Jane Rachel (creator); Jaworski, Alexander (Advisor); Webb, Ashley (Reader); Berson, David (Reader); Connors, Barry (Reader); Zampieri, Niccolo (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: neurodevelopment; axon guidance; Spinal cord; transcriptomics
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Genetic and Biochemical Analysis of the Grb10-Interacting GYF Protein 2 (GIGYF2): A Link Between the Insulin and Insulin-Like Growth Factor Hormonal Systems and Parkinson's Disease

Description:: The insulin (IR) and insulin-like growth factor receptors (IGF-IR) are critical mediators of growth, development and survival. Given their immense biological significance, a complex system …
Year:: 2010
Contributor:: Tsiaras, William G (creator); Smith, Robert (Director); Gruppuso, Philip (Reader); Sedivy, John (Reader); Guardavaccaro, Daniele (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: GIGYF2; GIGYF1; Grb10; IGF-IR; insulin receptor; Neurodegeneration; PARK11; CUL7; Cyclin D1; PARC; p53; SKP1; FBXW8; Insulin--Receptors; Parkinson's disease
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Genetic and Biochemical Characterization of Phospholipase Associated Metabolic Dysfunction in Drosophila melanogaster

Description:: Resistance to starvation is a classical complex trait, where varying genetic and environmental landscapes can greatly modify an animal’s ability to cope. In this study, …
Year:: 2021
Contributor:: Williams, Shawn (creator); DeLong, Alison (Reader); Wharton, Kristi (Reader); Tatar, Marc (Reader); Larschan, Erica (Reader); Gibbs, Allen (Reader); Rand, David (Advisor); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster--Genetics; Lipids--Metabolism; Neurodegeneration; Starvation
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Genetic Approaches to Understand the Timing of Gene Expression and Lineage Allocation in the Mouse Auditory System

Description:: Vital to the function of any organ system is the proper specification and distribution of cell types during development. This is especially true for the …
Year:: 2011
Contributor:: Brown, Stephen D (creator); Zervas, Mark (Director); Freiman, Richard (Reader); Johnson, Mark (Reader); Fallon, Justin (Reader); Oliver, Douglas (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: development; genetic inducible fate mapping; lineage; cell fate; auditory system; Economic development; Cell determination; Ear; Cochlear nucleus; Inferior colliculus
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Genetic Identification of Germline RNAi Components as Regulators of Segregation Distorter in D. melanogaster

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Description:: Mendelian inheritance relies on the segregation of allelic pairs during the production of gametes, allowing equal exposure of all genotypes to the forces of natural …
Year:: 2012
Contributor:: Gell, Selena L (creator); Reenan, Robert (Director); Judith, Bender (Reader); Rand, David (Reader); Michael, McKeown (Reader); Mellone, Barbara (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: meiotic drive; RNAi; Spermatogenesis
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Genetics, Genome Wide Association Studies, Babies, and Big Data: How the Bioinformatics Approach is Improving the Study of Preterm Birth

Description:: Preterm birth disparately impacts different groups of women based on a number of risk factors. Nearly half of the risk is attributed to genetic factors. …
Year:: 2021
Contributor:: Oluokun, Oluwafunto (creator); Padbury, James (thesis advisor); Uzun, Alper (reader); Schuster, Jessica (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Genetics; Premature infants; Databases; Premature labor; Curation
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

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Items (61-80) out of 209 results

Items (61-80) out of 209 results

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