Search Results

Active filters: CollectionMolecular Biology, Cell Biology, and Biochemistry Cancel selected facet

Refine your results

Collection

Format

Genre

Keywords

Items

Items (81-100) out of 209 results

Germ Line and Somatic Cell Divergence in Animal Development

Description:: A critical event in animal development is when germ line cells, which will one day become competent for producing eggs or sperm, are segregated away …
Year:: 2015
Contributor:: Swartz, Steven Zachary Z (creator); Wessel, Gary (Director); Casey, Dunn (Reader); Larschan, Erica (Reader); Richard, Freiman (Reader); Delong, Alison (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: germ line; PGC; Nanos; CNOT6; CCR4; FoxY; Wnt; beta catenin; Delta; Notch; Sea urchins; Notch genes
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Glial-expressed Gbb Impacts Growth of the Drosophila Neuromuscular Junction

Thumbnail for Glial-expressed Gbb Impacts …

Description:: Cell-cell communication is crucial for the function of an organism. In Drosophila, motor neurons signal from the ventral nerve cord (VNC) to muscles while surrounding …
Year:: 2019
Contributor:: Knight, Tracy A. (creator); Wharton, Kristi (thesis advisor); Oancea, Elena (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster--Genetics; Transforming growth factors-beta; Bone morphogenetic proteins
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

Full Record

Group 1 Innate Lymphoid Cells of the Submandibular Salivary Gland and Lacrimal Gland

Description:: Innate lymphoid cells (ILCs) are diverse innate lymphocytes that contribute to the immune response against pathogens and cancer cells, and play a variety of roles …
Year:: 2017
Contributor:: Erick, Timothy (creator); Brossay, Laurent (Advisor); Atwood, Walter (Reader); Wands, Jack (Reader); Sharma, Surendra (Reader); Lynch, Lydia (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Immunology; Cellular immunity; Natural immunity; Immune response; Immune system
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

HAP2(GCS1) is a conserved sperm-expressed gene required for fertilization

Description:: In flowering plants, two sperm cells develop in the pollen cytoplasm and are transported through floral tissues to an ovule by a pollen tube, a …
Year:: 2010
Contributor:: Frank, Aubrey C (creator); Johnson, Mark (Director); DeLong, Alison (Reader); Wessel, Gary (Reader); Petti, Wolfgang (Reader); Snell, William (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: HAP2; fertilization; Fertilization (Biology); Arabidopsis thaliana; Membrane fusion
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Heat Stress and Gene Expression: How does heat stress influence the activity and expression of certain heat sensitive genes in Arabidopsis thaliana and Solanum lycopersicum

Description:: As the Earth’s climate is rapidly changing, it has become increasingly important to understand how to improve agricultural output, crop productivity, and crop viability. By …
Year:: 2023
Contributor:: Ramirez, Camilo (creator); Johnson, Mark (thesis advisor); DeLong, Alison (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Genetics; Pollen; Arabidopsis thaliana--Genetics; Tomatoes; Heat--Physiological effect; Promoters (Genetics); Green fluorescent protein; Messenger RNA; Agrobacterium tumefaciens; Escherichia coli--Genetics
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

Full Record

Identification and Characterization of Small Molecule Inhibitors of the Endonuclease Encoded by the LINE-1 Retrotransposon

Thumbnail for Identification and Characterization …

Description:: Nearly half of the human genome is comprised of mobile genetic elements known as transposons. Most transposons in humans can no longer create new copies …
Year:: 2023
Contributor:: D'Ordine, Alexandra Marie (creator); Sedivy, John (Advisor); Jogl, Gerwald (Advisor); Delaney, Sarah (Reader); Fawzi, Nicolas (Reader); Neretti, Nicola (Reader); Gorbunova, Vera (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Biochemistry; Aging; retrotransposon; X-ray crystallography; LINE-1; Enzyme inhibitors; Cellular Senescence
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Identification and Characterization of T Cell Factor-4 (TCF-4) Isoforms of Wnt Signaling in Hepatocellular Carcinoma (HCC)

Description:: Background and Aims: The canonical Wnt signaling pathway is frequently activated in hepatocellular carcinoma (HCC). Although b-catenin is the principle effector protein of Wnt pathway, …
Year:: 2010
Contributor:: Tsedensodnom, Orkhontuya (creator); Wands, Jack (Director); Kim, Miran (Director); Freiman, Richard (Reader); Gruppuso, Philip (Reader); Wessel, Gary (Reader); Baffy, Gyorgy (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Wnt; b-catenin; HCC; TCF-4
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Identification and Regulation of White-Opaque Phenotypic Switching in Candida tropicalis

Thumbnail for Identification and Regulation …

Description:: Fungal pathogens utilize a variety of strategies to adapt to environmental cues and to thrive in different host niches. This includes phenotypic switching, in which …
Year:: 2015
Contributor:: Porman, Allison Marly (creator); Bennett, Richard (Director); Fairbrother, William (Reader); Bender, Judith (Reader); Johnson, Mark (Reader); Whiteway, Malcolm (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: phenotypic switch; fungal pathogen; epigenetic switch; transcriptional regulation; Candida
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Identification of Aged Cell Types in Mouse Skeletal Muscles

Description:: The mechanism of the muscle aging is a poorly understood subject. The senescence driven aging model is not readily applicable in the muscles, because mature …
Year:: 2024
Contributor:: Seo, Jiwon (creator); Johnson, Mark (Reader); Dawson, Michelle (Reader); Kreiling, Jill (Reader); Sedivy, John (Advisor); Robbins, Paul (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Aging; LINE-1; Senescence; mouse skeletal muscles; Muscle cell types; RNAscope; RNA FISH; ORF1; p21; p16
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Identifying embryonic mechanisms that induce a germ cell fate in sea stars

Thumbnail for Identifying embryonic mechanisms …

Description:: Germ cell specification is required for reproduction in all sexually reproducing animals. During animal development, animals can specify their germ cells through inheritance of maternal …
Year:: 2017
Contributor:: Fresques, Tara (creator); Wessel, Gary (Advisor); Creton, Robbert (Reader); Freiman, Richard (Reader); Dunn, Casey (Reader); Wharton, Kristi (Reader); Extavour, Cassandra (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Developmental biology; Echinodermata; Germ cells; Reproduction
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Identifying Residues that Coordinate Mfd on Double-Stranded DNA

Thumbnail for Identifying Residues that …

Description:: Mfd is a transcriptional-repair coupling factor (TRCF) that is involved in a variety of cellular processes involving stalled or paused RNA polymerases, such as transcription …
Year:: 2019
Contributor:: Kim, David Donghwan (creator); Deaconescu, Alexandra (thesis advisor); Seto, Christopher (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Molecular biology; DNA damage; DNA repair; Mfd
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

Full Record

Immunoregulatory functions of KLRG1 and its associated phosphatases

Thumbnail for Immunoregulatory functions of …

Description:: The invasion of foreign pathogens and the development of cancerous cells result in human infections and diseases. The severity of this outcome is dependent on …
Year:: 2012
Contributor:: Banh, Cindy (creator); Brossay, Laurent (Director); Atwood, Walter (Reader); Gruppuso, Philip (Reader); Page, Rebecca (Reader); Margulies, David (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: KLRG1; immune receptors; SHIP-1; NK cells; Cadherins; Phosphatases; Killer cells
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into Directional Motor-Driven RNA Localization from the Xenopus Oocyte

Thumbnail for Insights into Directional …

Description:: RNA localization is a widely conserved mechanism for generating cellular asymmetry. In Xenopus oocytes, microtubule-dependent transport of RNAs to the vegetal cortex underlies germ layer …
Year:: 2011
Contributor:: Gagnon, James A (creator); Mowry, Kimberly (Director); Johnson, Mark (Reader); McKeown, Mike (Reader); Dahlberg, Albert (Reader); Singer, Robert (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Molecular Motors; RNA Localization; Developmental biology
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into Maternal mRNA Localization: Characterization of a New Cytoplasmic RNA Granule

Description:: Cytoplasmic mRNA localization is understood as an important biological strategy for establishing cell and developmental polarity in a variety of organisms and cell types. In …
Year:: 2019
Contributor:: Neil, Christopher Richer (creator); Johnson, Mark (Reader); Larschan, Erica (Reader); Fallon, Justin (Reader); Mowry, Kimberly (Advisor); Marlow, Florence (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Molecular biology; Biochemistry; RNA
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into Prion Biology: Mechanistic Contributions and Phenotypic Consequences of Oligopeptide Repeats

Description:: Prions are proteins that can adopt multiple distinct and stable conformations, a properly folded form and a collection of misfolded or prion forms that are …
Year:: 2015
Contributor:: Langlois, Christine Ricalo (creator); Serio, Tricia (Director); Bender, Judith (Reader); Hart, Anne (Reader); Salomon, Arthur (Reader); Hines, Justin (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Prion propagation; Sup35; oligopeptide repeats
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into species recognition, gametophyte growth, and cell signaling dynamics in Arabidopsis

Description:: In flowering plants, egg cells are housed inside of the flower and immotile sperm produced by the pollen grain are delivered to the flower. The …
Year:: 2020
Contributor:: Ponvert, Nathaniel Donaldson (creator); Johnson, Mark (Advisor); DeLong, Alison (Reader); Bennett, Richard (Reader); Salomon, Arthur (Reader); Franklin-Tong, Vernonica (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Molecular biology; Plant molecular biology
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into the Genetics of Aging in Drosophila melanogaster

Description:: Studying the biological mechanisms of the aging process in the fruit fly Drosophila melanogaster has been crucial to the advancement of the field. In particular, …
Year:: 2014
Contributor:: Whitaker, Rachel E. (creator); Helfand, Stephen (Director); Reenan, Robert (Reader); Sedivy, John (Reader); Neretti, Nicola (Reader); Rogina, Blanka (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Sir2; dietary restriction; Drosophila melanogaster; Aging
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Insights into the Impact of Admixture on Human Genetic Variation

Description:: Since the completion of the Human Genome Project and the first whole human genome sequence in 2003, the number of whole human genome sequences available …
Year:: 2023
Contributor:: Funk, Alyssa (creator); Huerta-Sanchez, Emilia (Advisor); Johnson, Mark (Reader); Ramachandran, Sohini (Reader); Weinreich, Daniel (Reader); Goldberg, Amy (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Genomics; Natural selection; Human genetics; Human population genetics; Archaic Admixture; Modern Admixture
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Interrogating the Non-coding Role of Human Disease Variants in Splicing

Thumbnail for Interrogating the Non-coding …

Description:: Substitutions that disrupt pre-mRNA splicing are a common cause of genetic disease. On average, 13.4% of all hereditary disease alleles are classified as splicing mutations …
Year:: 2019
Contributor:: Rhine, Christy Lynn (creator); Fairbrother, William (Advisor); Johnson, Mark (Reader); Freiman, Richard (Reader); Creton, Robbert (Reader); Graveley, Brenton (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: RNA; RNA splicing
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Investigating Christianson syndrome neuronal development in induced pluripotent stem cells

Thumbnail for Investigating Christianson syndrome …

Description:: Christianson syndrome (CS) is an X-linked, monogenic, neurological disorder caused by mutations in SLC9A6, the gene encoding Na+/H+ exchanger 6 (NHE6). Symptoms of CS include …
Year:: 2017
Contributor:: Maguire, Abbie Madeline (creator); Morrow, Eric (Advisor); Freiman, Richard (Reader); Larschan, Erica (Reader); Oancea, Elena (Reader); Chamberlain, Stormy (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: induced pluripotent stem cells; neurodevelopment; Christianson syndrome
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Full Record

Search Results

Active filters

Refine your results

Collection

Format

Genre

Keywords

Keywords

Items

Items (81-100) out of 209 results

Items (81-100) out of 209 results

Feedback