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Items (121-140) out of 209 results

Molecular dissection of the dual functioning Drosophila ALK1/2 BMP type I receptor ortholog Saxophone

Description:
The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
Year:
2014
Contributor:
Le, Viet Quoc (creator)
Wharton, Kristi (Director)
DeLong, Alison (Reader)
McKeown, Michael (Reader)
Page, Rebecca (Reader)
Rosen, Vicki (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Sax
BMP signaling
receptor kinase activation
type I receptor
type II receptor
ALK2
ACVR1
FOP
Drosophila
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Molecular insights into the homotypic and heterotypic interactions that promote liquid-liquid phase separation of the RNA-binding protein Fused In Sarcoma

Description:
Subcellular organization is important for maintaining cellular homeostasis within eukaryotic cells. In addition to membrane-bound organelles, membraneless compartmentalization of the cell occurs via liquid-liquid phase …
Year:
2020
Contributor:
Murthy, Anastasia C (creator)
Fawzi, Nicolas (Advisor)
Hart, Anne (Reader)
Jogl, Gerwald (Reader)
Lisi, George (Reader)
Mowry, Kimberly (Reader)
Bosco, Daryl (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Nuclear magnetic resonance spectroscopy
liquid-liquid phase separation
RNP granules
Structural biology
Protein assembly
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Molecular insights into the homotypic and heterotypic interactions that promote liquid-liquid phase separation of the RNA-binding protein Fused In Sarcoma

Description:
Subcellular organization is important for maintaining cellular homeostasis within eukaryotic cells. In addition to membrane-bound organelles, membraneless compartmentalization of the cell occurs via liquid-liquid phase …
Year:
2020
Contributor:
Murthy, Anastasia C (creator)
Fawzi, Nicolas (Advisor)
Hart, Anne (Reader)
Jogl, Gerwald (Reader)
Lisi, George (Reader)
Mowry, Kimberly (Reader)
Bosco, Daryl (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Nuclear magnetic resonance spectroscopy
liquid-liquid phase separation
RNP granules
Fused in Sarcoma
Structural biology
Protein assembly
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Molecular Mechanisms of CaV2.2 Calcium Channel Regulation

Description:
CaV2.2 calcium channels are critical regulators of cellular calcium entry in neurons and couple electrical stimulation to neurotransmitter release. These channels are responsible for mediating …
Year:
2011
Contributor:
Marangoudakis, Spiro A (creator)
Lipscombe, Diane (Director)
Reenan, Robert (Reader)
Laney, Jeffrey (Reader)
Page, Rebecca (Reader)
Roche, Katherine (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Cav2.2
voltage-gated calcium channel
N-type
alternative splicing
ubiquitination
Calcium channels
Ubiquitin
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

More Than Meets the Eye: Molecular Diversity of the Intrinsically Photosensitive Ganglion Cells Regulating Circadian Photoentrainment

Description:
Chapters 1-3: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are rare mammalian photoreceptors essential for non-image-forming vision functions, such as circadian photoentrainment and the pupillary light …
Year:
2017
Contributor:
Berg, Daniel (creator)
Berson, David (Advisor)
Wessel, Gary (Reader)
Barnea, Gilad (Reader)
Morrow, Eric (Reader)
Sanes, Joshua (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
iprgcs
opn4
melanopsin
Retinal ganglion cells
rasgrp1
tbx20
rbp4
transgenic reporter
Circadian rhythms
Visual pathways
cell types
terminal differentiation
photoentrainment
molecular diversity
non-image forming
phototransduction
intrinsically photosensitive
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

MSL2 binding domain of CLAMP is required for faithful targeting of the MSL complex

Description:
In male Drosophila, the Dosage Compensation Complex (DCC) is targeted, via a transcription factor (TF), called the Chromatin-linked Adaptor for MSL complex (CLAMP), to the …
Year:
2024
Contributor:
Aldana, Melissa (creator)
Larschan, Erica (thesis advisor)
Mowry, Kimberly (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Drosophila
Genetic regulation
CLAMP
CUT & RUN
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Neural Circuits for controlling Drosophila Locomotion

Description:
An organism’s survival relies on its ability to navigate through the environment. To perform this task, animals must construct a map of space and translate …
Year:
2024
Contributor:
Crown, Anthony (creator)
Barnea, Gilad (Advisor)
Fleischmann, Alexander (Reader)
O'Connor-Giles, Kate (Reader)
Larschan, Erica (Reader)
Ruta, Vanessa (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Drosophila melanogaster
Animal locomotion
Neural circuitry
Transsynaptic tracing
Neuroscience
Navigation
Courtship in animals
Sexual dimorphism (Animals)
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Non-classical T cell responses to cytomegalovirus infection

Description:
Non-classical T cell responses to murine cytomegalovirus (MCMV) are incompletely understood, in part due to a lack of tools to study them. To uncover the …
Year:
2024
Contributor:
Reilly, Shanelle Priscilla (creator)
Brossay, Laurent (Advisor)
Freiman, Richard (Reader)
Beura, Lalit (Reader)
Siddle, Katherine (Reader)
Cantorna, Margherita (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Cytomegalovirus infections
Non-classical T cells
Qa-1
HLA-E
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Observing the natural and heteromorphic organization of the human genome in nanoscale resolution

Description:
The human genome is organized in a hierarchical manner from higher order to lower order structures. At the highest level are chromosome territories that are …
Year:
2022
Contributor:
Horrell, Jeremy Christian (creator)
Neretti, Nicola (Advisor)
Sedivy, John (Advisor)
Larschan, Erica (Reader)
Freiman, Richard (Reader)
Creton, Robbert (Reader)
Nir, Guy (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Chromatin
nuclear architecture
High resolution imaging
3d fish
Oligopaints
stochastic optical reconstruction microscopy
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Organizing the oocyte: Identification and characterization of a novel biomolecular condensate in Xenopus

Description:
RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular and developmental polarity. During Xenopus oocyte development, RNAs …
Year:
2021
Contributor:
Cabral, Sarah (creator)
Larschan, Erica (Reader)
de Graffenried, Christopher (Reader)
Hart, Anne (Reader)
Seydoux, Geraldine (Reader)
Mowry, Kimberly (Advisor)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA localization
Phase separation
RNA-protein interactions
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Ovarian transplants in wild type and biglycan/decorin double knockout mice

Description:
Preterm premature rupture of membranes (PPROM) is responsible for 40% of premature births. In humans, the progeroid variant of Ehlers-Danlos Syndrome (EDS) is associated with …
Year:
2016
Contributor:
Perecki, Natalia (author)
Lechner, Beatrice (advisor)
Genre:
theses
Subject:
Ovaries > Transplantation
Biglycan
Pregnancy
PPROM
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Pathways regulating C. elegans exercise-induced fatigue during prolonged swimming activity

Description:
Fatigue is poorly understood, beyond muscle energetics. For C. elegans, swimming is a more energetically costly behavior than crawling and can be classified as a …
Year:
2022
Contributor:
Schuch, Kelsey Nicole (creator)
Hart, Anne (Advisor)
DeLong, Alison (Reader)
Wharton, Kristi (Reader)
Weinreich, Daniel (Reader)
Bai, Jihong (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Neuromodulation
Caenorhabditis elegans
Sleep
Fatigue
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Phenotyping the ΔIg3-MuSK Mouse Model Using Automated Continuous Behavior Monitoring

Description:
The MuSK-BMP signaling pathway has been implicated in neuromotor and cognitive regulation, and adult hippocampal neurogenesis, yet its behavioral consequences remain insufficiently understood. To selectively …
Year:
2025
Contributor:
Wang, Jenny Y H (creator)
Fallon, Justin (Advisor)
Andrade, Arturo (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Adult Neurogenesis
Automated Continuous Behavioral Monitoring
Mouse behavior
Deep learning (Machine learning)
MuSK-BMP
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

PHEROMONE SIGNALING, MATING AND BIOFILM FORMATION IN CANDIDA SPECIES.

Description:
Candida species are a group of opportunistic fungal pathogens that cause life-threatening illness in the immunocompromised, but typically inhabit the human gastrointestinal tract as a …
Year:
2015
Contributor:
Jones, Stephen Knox (creator)
Bennett, Richard (Director)
Wessel, Gary (Reader)
Larschan, Erica (Reader)
Page, Rebecca (Reader)
Hogan, Deborah (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
fungi,yeast,biofilm,pheromones,signaling,mating,protease,interspecies,phenotypic switching
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Phosphoproteomic Analysis of T Cell Receptor and Chimeric Antigen Receptor Signalling: Pathway Discovery and Regulatory Mechanisms

Description:
Mass spectrometry (MS) based proteomics has revolutionised biological discovery by allowing for high-throughput, accurate quantification of proteins, posttranslational modifications, and protein-protein interactions. Proteomics has been …
Year:
2026
Contributor:
Callahan, Aurora (creator)
Salomon, Arthur (Advisor)
Fawzi, Nicolas (Reader)
DeLong, Alison (Reader)
Beura, Lalit (Reader)
High, Anthony (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Immunology
Mass spectrometry
Cancer--Immunotherapy
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Phylogenetic and Phenotypic Studies of the Extremophile Chroococcidiopsis (Cyanobacterium). A Foundation for Synthetic Biology in Space.

Description:
Understanding the mechanisms used by organisms living in extreme environments on Earth is a first step towards rationally designing organisms for living in space. The …
Year:
2012
Contributor:
Cumbers, John Robert (creator)
Tatar, Marc (Director)
Rothschild, Lynn (Director)
Dunn, Casey (Reader)
Patterson, David (Reader)
Weinreich, Daniel (Reader)
Wessel, Gary (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Chroococcidiopsis
extremophile
halophile
halophyly
halotolerance
moderate halophile
phylogenetics
Pleurocapsales
salt tolerance
radiation resistance
UV tolerance
ISRU
BISRU
in situ resource utilization
biological in situ resource utilization
Cyanobacteria
Extreme environments--Microbiology
Halophilic organisms
Phylogeny
Radiation tolerance
Synthetic biology
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Profiling of mTORC1 Signaling in Rat Liver Using Mass Spectrometry

Description:
Our understanding of signaling networks in the physiological context of an organism remains limited, partly due to the technical challenge of identifying serine/threonine phosphorylated peptides …
Year:
2011
Contributor:
Demirkan, Gokhan (creator)
Gruppuso, Philip (Director)
Bazemore-Walker, Carthene (Reader)
Hixson, Douglas (Reader)
Salomon, Arthur (Reader)
Ping, Peipei (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
mTOR
phosphoproteomics
Rapamycin
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Protein Phosphatase 2A Controls Seedling Growth Through Differential Regulation of Ethylene Biosynthesis

Description:
The gaseous hormone ethylene is a master regulator of development and physiology throughout the plant life cycle. Ethylene biosynthesis is stringently regulated to maintain low …
Year:
2012
Contributor:
Skottke, Kyle Raymond (creator)
DeLong, Alison (Director)
Laney, Jeffrey (Reader)
Johnson, Mark (Reader)
Arthur, Salomon (Reader)
Schaller, Eric (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
PP2A
Ethylene
Plant hormones
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Reduced fatty acid oxidation contributes to hyperoxia-induced endothelial-to-mesenchymal transition in vitro

Description:
Premature infants, born before 37 weeks of gestation, need respiratory supports including mechanical ventilation and supplementary oxygen to maintain life. While ventilators and oxygen supplementation …
Year:
2021
Contributor:
Chang, Julia (creator)
Yao, Hongwei (thesis advisor)
Heywood, Peter (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Pulmonary hypertension
Bronchopulmonary dysplasia
Fatty acid oxidation
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Regulating Transcription, Epigenetics, and Stemness During Embryonic Male Germ Cell Development

Description:
Abstract of “Regulating Transcription, Epigenetics, and Stemness During Embryonic Male Germ Cell Development” by Myles A. Bartholomew, Ph.D., Brown University, May 2026. Male infertility is …
Year:
2026
Contributor:
Bartholomew, Myles Austin (creator)
Freiman, Richard (Advisor)
Johnson, Mark (Reader)
DeLong, Alison (Reader)
Neretti, Nicola (Reader)
Laird, Diana (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
epigenetics
Transcriptional regulation
Germ cells
Fertility
Stem cells
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Items (121-140) out of 209 results