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Items (161-180) out of 209 results

TDG, NCP, and other TLAs (Three Letter Abbreviations) of DNA BER: Initiation of DNA Base Excision Repair in Nucleosome Core Particles

Description:
Repair of damaged DNA is indispensable for not only cellular, but also organismal survival. Nucleobase lesions, which arise from endogenous or exogenous sources of damage, …
Year:
2022
Contributor:
Tarantino, Mary Elizabeth (creator)
Delaney, Sarah (Advisor)
Morrow, Eric (Reader)
Deaconescu, Alexandra (Reader)
Sedivy, John (Reader)
Towle-Weicksel, Jamie (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Biochemistry
Toxicology
DNA damage
Enzymology
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Technologies for Phosphoproteomic Interrogation of T Cell Signaling

Description:
The ability to detect and adapt to changing conditions and circumstances is a requirement of life at both the organismal and cellular levels. Inside the …
Year:
2017
Contributor:
Belmont, Judson (creator)
Salomon, Art (Advisor)
Gruppuso, Philip (Reader)
de Graffenreid, Christopher (Reader)
Neretti, Nicola (Reader)
Gerber, Scott (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
T cells
Databases
Proteomics
Mass spectrometry
Bioinformatics
Software
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Aging Heart: Mechanisms of Arrhythmogenesis and Sudden Cardiac Death

Description:
The incidence of sudden cardiac death increases 5 to 40–fold in humans over 65 years as compared to younger individuals. The mechanisms underlying this phenomena …
Year:
2018
Contributor:
Murphy, Kevin Ronald (creator)
Koren, Gideon (Advisor)
Sedivy, John (Reader)
Rand, David (Reader)
Tatar, Marc (Reader)
Sheu, Shey-Shing (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Aging
Sudden Cardiac Death
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Allosteric Regulation of Macrophage Migration Inhibitory Factor

Description:
Abstract of The Allosteric Regulation of Macrophage Migration Inhibitory Factor, by Erin Skeens, Ph.D., Brown University, October 2025 Macrophage Migration Inhibitory Factor (MIF) is a …
Year:
2025
Contributor:
Skeens, Erin (creator)
Lisi, George (Advisor)
Fawzi, Nicolas (Reader)
Jogl, Gerwald (Reader)
Ayala, Alfred (Reader)
Massi, Francesca (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Biochemistry
Proteins
Structural biology
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Balance Between Prion Propagation and Proteostasis Can Be Perturbed Through Multiple Pathways to Evoke Prion Curing

Description:
Cells have a robust protein quality control (PQC) network that ensures proteins reach and maintain their proper fold, and breakdowns in this network result in …
Year:
2014
Contributor:
Klaips, Courtney L (creator)
Serio, Tricia (Director)
Beale, Samuel (Reader)
Bennett, Richard (Reader)
Page, Rebecca (Reader)
Tuite, Mick (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Sup35
[PSI]
Hsp104
chaperone
heat shock
proteostasis
Tricia Serio
Prions
Molecular chaperones
Quality control
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The chromatin and transcriptional landscape of senescent cells

Description:
Abstract of “The chromatin and transcriptional landscape of senescent cells”, by Steven W. Criscione, Ph.D., Brown University, May 2017 Senescent cells are recognized as one …
Year:
2016
Contributor:
Criscione, Steven W. (creator)
Neretti, Nicola (Advisor)
Sedivy, John (Advisor)
Fairbrother, William (Reader)
Reenan, Robert (Reader)
Helfand, Stephen (Reader)
Vijg, Jan (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Biotechnology
Cytology
Older people
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The CLAMP protein is essential in Drosophila in mediating dosage compensation through increased targeting to the X-chromosome and during development as a non-sex specific transcription factor.

Description:
Dosage compensation in Drosophila is a valuable model for studying how transcription complexes are targeted throughout the genome because all of the genes along the …
Year:
2014
Contributor:
Soruco, Marcela (creator)
Erica, Larschan (Director)
Mark, Johnson (Reader)
Robert, Reenan (Reader)
Nicola, Neretti (Reader)
Fred, Winston (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
dosage compensation
gene regulation
Genetic regulation
Transcription factors
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Discovery of Multiple, Novel Mechanisms Used by ser/thr Protein Phosphatases to Recognize and Dephosphorylate Their Substrates

Description:
The protein ser/thr phosphatases (PSPs) dephosphorylate over 2000 of key biological targets, making them attractive therapeutic targets. The serine/threonine protein phosphatases 1 and 2B (PP1; …
Year:
2019
Contributor:
Wang, Xinru (creator)
DeLong, Alison (Reader)
Page, Rebecca (Advisor)
Fawzi, Nicolas (Reader)
Creton, Robbert (Reader)
Ghose, Ranejeet (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Nuclear magnetic resonance spectroscopy
Phosphorylation
Cell signaling
Enzymes
X-ray crystallography
structure biology
Intrinscally disordered proteins
Phosphoprotein phosphatases
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Dynamic Interactions of the alpha2 Repressor Engender Robust Repression of Developmentally Regulated Genes while Priming them for Rapid Activation

Description:
In budding yeast, mating-type identity is determined genetically by the MAT locus, which encodes a set of transcriptional regulators that direct the cell to execute …
Year:
2009
Contributor:
DeSimone, Alec M. (creator)
Laney, Jeffrey (director)
Landy, Arthur (reader)
Gerbi, Susan (reader)
Freiman, Richard (reader)
Reese, Joseph (reader)
Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
phenotypic switching mating-type switching
Language:
English
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Function of the CLAMP Zinc Finger Protein in Targeting MSL Complex to the X-chromosome during Dosage Compensation in Drosophila Melanogaster

Description:
Coordinate gene regulation is critical to promote normal development and prevent disease. How domains of co-regulation are established in vivo remains poorly understood. X-chromosome dosage …
Year:
2014
Contributor:
Chery , Jessica (creator)
Larschan, Erica (Director)
Freiman, Richard (Reader)
Delong, Alison (Reader)
Bender, Judith (Reader)
Buratowski, Stephen (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
CLAMP
zinc finger protein
GA-repeats
gene regulation
dosage compensation
Zinc-finger proteins
Genetic regulation
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Genetic and Biochemical Analysis of the Chromatin-Targeting Protein BRD2 in Mammalian Development

Description:
The regulation of gene expression in eukaryotic cells is controlled by both chromatin dynamics and the actions of myriad components of the transcriptional machinery. While …
Year:
2013
Contributor:
Donovan, Diana J (creator)
Freiman, Richard (Director)
Wilson, Angus (Reader)
McKeown, Michael (Reader)
Johnson, Mark (Reader)
Zervas, Mark (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
BRD2
bromodomain
GCN5
neural development
embryogenesis
Embryology
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The genome and DNA puff sequences of the fungus fly, Sciara coprophila, and genome-wide methods for studying DNA replication

Description:
DNA replication initiates from any given origin at most once per cell cycle to ensure perfect duplication of the hereditary material. DNA re-replication occurs when …
Year:
2017
Contributor:
Urban, John (creator)
Gerbi, Susan (Advisor)
Larschan, Erica (Reader)
Mark Welch, David (Reader)
Raphael, Benjamin (Reader)
Johnson, Mark (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Genomics
DNA replication
Nanopore sequencing
genome assembly
sciara coprophila
DNA amplification
DNA puffs
Lambda exonuclease
Illumina
Pacific Biosciences
Oxford Nanopore Technologies
BioNano Genomics
DNA sequencing
RNA sequencing
fungus fly
ultra long reads
DNA modifications
origins of replication
G-quadruplexes
nucleosome phasing
new model systems
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Impact of Genetic and Epigenetic Interactions on Propagation of the [PSI+] Prion

Description:
Prions are unique proteins that can exist in multiple states. In the prion form these proteins self-replicate, directing other like molecules to adopt the prion …
Year:
2008
Contributor:
Strbuncelj, Martina (creator)
Serio, Tricia (director)
Freiman, Richard (reader)
Zervas, Mark (reader)
Derkatch, Irina (reader)
Dahlberg, Albert (director)
Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
prefoldin
Prions
Yeast
Epigenetics
Language:
English
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Impacts of Hispanic and Latinx Patients’ Experienced Disparities and the COVID-19 Pandemic’s Onset on Cancer Screening and Advanced Care: A Biomedical Informatics Perspective

Description:
Minorities experience healthcare ethnic and racial disparities, which were accompanied by additional destabilizing influences brought upon by the COVID-19 pandemic. Hindrances to early screening and …
Year:
2024
Contributor:
Ravich, Jacob Winston (creator)
Sarkar, Indra (Advisor)
Hilliard, Ross (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Medical screening
Improving cancer screening rates
biomedical informatics
COVID-19 Pandemic (2020-)
Healthcare disparities
Medicine and Health Sciences
Brown University
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Cancer--Patients--Medical care
Hispanic/Latinx Patient Marginalization
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

The Inhibition of Kit Ligand in a Mouse Model of Ovarian Cancer

Description:
Among cancers that affect the female reproductive system, ovarian cancer exhibits the highest mortality rate, with a stark five-year survival rate for those having late-stage …
Year:
2023
Contributor:
Wornow, Sarah (creator)
Freiman, Richard (thesis advisor)
Dubielecka-Szczerba, Patrycja (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Cancer
ovarian cancer
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Initiation of Base Excision Repair in Nucleosome Core Particles

Description:
Despite being essential for organismal survival, genomic DNA is chemically reactive and susceptible to modification to generate mutagenic and/or cytotoxic lesions. These lesions include oxidation, …
Year:
2019
Contributor:
Kennedy, Erin Elizabeth (creator)
Delaney, Sarah (Advisor)
Freiman, Richard (Reader)
Deaconescu, Alexandra (Reader)
Morrow, Eric (Reader)
Beuning, Penny (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Molecular biology
Chromatin
Biochemistry
DNA repair
Enzymes
chemical biology
DNA damage
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Life Cycle of the Intron: What Rare Splicing Intermediates Can Teach Us About Pre-mRNA Processing and Gene Expression

Description:
Pre-mRNA splicing is an RNA processing step in which introns are excised and exons are ligated together. In this work, I use novel algorithms to …
Year:
2018
Contributor:
Taggart, Allison Jordan (creator)
Fairbrother, William (Advisor)
Reenan, Robert (Reader)
Neretti, Nicola (Reader)
Freiman, Richard (Reader)
Pleiss, Jeffrey (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA sequencing
Bioinformatics
RNA
RNA splicing
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Mechanism of Dominant-Negative Prion Inhibition Reveals the Crucial Interplay between Protein Misfolding and its Cellular Environment

Description:
The prion hypothesis provides an explanation for a diverse collection of previously inexplicable phenomena, ranging from the appearance, progression and spread of neurodegenerative disease in …
Year:
2012
Contributor:
DiSalvo, Susanne (creator)
Serio, Tricia (Director)
Chernoff, Yury (Reader)
Mowry, Kimberly (Reader)
Johnson, Mark (Reader)
Peti, Wolfgang (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
chaperone
protein misfolding
Prions
Amyloid
Quality control
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Molecular Basis of Calcineurin Inhibition by Protein Regulators

Description:
Ser/Thr phosphatases dephosphorylate their targets with high specificity, yet the structural determinants of substrate recognition and dephosphorylation are poorly understood. Calcineurin (CN) is a conserved …
Year:
2013
Contributor:
Grigoriu, Simina r (creator)
Peti, Wolfgang (Director)
Delaney, Sarah (Reader)
Fairbrother, William (Reader)
Jogl, Gerwald (Reader)
Ellman, Jonathan (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
calcineurin
PP3
PP2B
A238L
RCAN1
FK506
Cyclosporin A
immunosuppressant
immunophillin
FKBP
cyclophilin
LxVP
PxIxIT
ITC
NMR
NFAT
RII
Cyclosporine
Immunosuppressive agents
Peptidylprolyl isomerase
Phosphatases
X-ray crystallography
Calcium
Phosphorylation
Molecular dynamics
Language:
English
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

The Neural Effect of Chitinase-3-like Protein 1 (CHI3L1/YKL-40) in Neuroinflammation & Alzheimer’s Disease

Description:
Alzheimer’s Disease (AD) is an age-related neurological disorder, with pathological hallmarks including the accumulation extracellular amyloid plaques consisting of amyloid beta (Aβ), processed from amyloid …
Year:
2025
Contributor:
Connolly, Kevin (creator)
Huang, Alvin (Advisor)
Sedivy, John (Reader)
Lee, Chun (Reader)
Webb, Ashley (Reader)
Musiek, Erik (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Neurons
Alzheimer's disease
Neurodegeneration
Stem cells
neuroinflammation
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Items (161-180) out of 209 results