All disciplines of biomedical research utilize in vitro models to answer a range of biological questions. Traditional in vitro models, two-dimensional (2D) cell monolayers, fail …
Abstract of “Endocrine Disruption of the Developing Human Fetal Prostate” by Camelia M. Saffarini, Ph.D., Brown University, May 2014 Prostate cancer is a major concern …
Abstract of Human Cell-Based In Vitro Toxicity Testing Landscape: Market Analysis and Trends Report, by Megan Marie Grant, Master of Science, Brown University, May 2020. …
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The five-year survival rate of women diagnosed with stage IV high-grade serous epithelial ovarian cancer …
Endocrine disruptors are a broad class of toxicants with the ability to alter and/or interfere with normal endocrine signaling. The perinatal period is particularly vulnerable …
DNA Microarrays have become an indispensable technique inbiomedical research. The raw measurements from microarrays undergo anumber of preprocessing steps before the data are converted to …
Skeletal muscle in vitro models have traditionally utilized mammalian cell lines isolated from rat or mouse skeletal muscles. These models have been extensively validated in …
Fibrosis is a multifactorial process characterized by the excessive accumulation of extracellular matrix (ECM), increased tissue stiffness, and decreased elasticity. To understand how growth factor …
The Sertoli cell is the "support cell" of the testis. The number of Sertoli cells which populate the testis during peri-pubertal development dictate the number …
Standard toxicity testing of chemicals to assess risk in humans is commonly done on animals. The problem, however, is that animals have been found to …
In 1977, Emmanuel Farber, Dennis Solt and Alan Medline reported carcinogen-induced hyperplastic lesions in a model of liver carcinogenesis. Lesions that grew following this protocol …
Vapor intrusion modeling generally involves solving the soil gas flow and volatile organic compound vapor transport equations in the soil subsurface and from there into …
