The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) …
Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control …
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …
Yariv reagents are tris-azo dyes used in plant biology that bind specifically to arabinogalactan proteins (AGPs), a vital component of plant cell walls involved in …
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Recent developments in mass spectrometer technology has increased the sensitivity and speed to an unprecedented level, along with the continuing improvements of high performance liquid …
Reactive sulfur species (RSS) belong to a class of biologically relevant molecules that play a crucial role in redox homeostasis. Abnormalities in the regulation of …
The widespread use of nanomaterial-containing consumer products increases the potential for human and environmental exposure, and has raised concerns about the adverse impacts associated with …
The widespread use of nanomaterials in established and emerging technologies will inevitably lead to human and environmental exposures that must be characterized and managed to …
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis …
Streptomyces are Gram-positive, filamentous, soil-dwelling saprophytic bacteria that are the source of a vast array of bioactive secondary metabolites. The albaflavenone biosynthetic gene cluster in …
The current reliance on finite fossil fuels for the production of commodity chemicals has been recognized as unsustainable, and therefore has led to increasing pressure …
CO2 functionalization to commodity chemicals and molecular energy provide an powerful mechanism to leverage one of the world most abundant alternative sustainable carbon resources. This …
Pulsed gradient spin-echo (PGSE) diffusion NMR spectroscopy was designed to measure diffusion coefficients and deduce the hydrodynamic radii of molecules in solution. By incorporation of …
Understanding the "how" and "why" of chemical reactions requires rapid snapshots of a system's transient states. One approach is pulsing the probing radiation, namely x-radiation …
Infectious diseases are the 2nd leading cause of death worldwide and pose a global health problem that requires constant effort towards the discovery of new …
Structural dynamics of molecular systems, i.e. the change of the arrangement of atoms and functional groups over time, is the essence of many chemical processes. …
Efforts to characterize proteins found in the outer membrane of gram-negative bacteria have been steadily increasing due to the promise of expanding our understanding of …
Cross-linked polymer shells are coated at the surface of gold nanoparticles through surface-initiated ring-opening metathesis polymerization followed by selective cross-linking. The stability of the cross-linked …
