As one of the most prevalent pediatric cancers in sub-Saharan Africa, endemic Burkitt lymphoma (eBL) has a 15-fold higher incidence than the sporadic (sBL) subtype …
The therapeutic potential of mesenchymal stem/stromal cells (MSCs) lies mainly in their immunomodulatory activity, which can be used to effect overall changes in the body’s …
Cancer is characterized by heterogeneity at multiple scales, with implications for diagnosis, prognosis, and treatment. Major advances in genomics have led to a proliferation of …
Autism is a developmental disability with variability in phenotypic features and genetic characteristics and affects 1% of children worldwide. Genetic and environmental factors are considered …
This dissertation aims to develop several statistical methods for learning the manifold and topology structures of data, provide the corresponding theoretical foundations, and apply the …
This dissertation evaluates the hypothesis that the occurrence and severity of acute medical events are linked to a patient’s underlying long-term health state and their …
The discipline of protein evolution aims to understand the principles and driving forces whereby new protein-coding genes, protein structures, and biological functions emerge due to …
Advances in sequencing technologies in the last decade have enabled us to profile various genomic features at the single-cell resolution, such as gene expression and …
Coordinated migration patterns emerge from the interactions of discrete individuals, ranging from self-propelled particles and mammalian cells at the microscopic scale to robots and animals …
In the past ten years, the amount of genetic data available to researchers has increased exponentially. This wealth of data has enabled researchers to identify …