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Items (1-14) out of 14 results

A 3D In Vitro Ring Model with Macrophage and Fibroblast Co-culture: A Platform for Preclinical Fibrosis Studies as an Alternative to Animal Testing

Description:: Abstract This study presents a scaffold-free 3D ring-shaped co-culture model composed of human dermal fibroblasts and THP-1 monocyte-derived macrophages to recapitulate cellular interactions associated with …
Year:: 2026
Contributor:: Kim, Yaunghyun (creator); Morgan, Jeffrey (Advisor); Raimondo, Theresa (Advisor); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: tissue engineering; Fibroblasts; Fibrosis; Macrophages; 3D in vitro models; 3D tissue engineering
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A NOVEL DUAL-FUNCTION PLATFORM FOR THE TREATMENT OF RECURRENT BACTERIAL VAGINOSIS (BV)

Description:: Bacterial vaginosis (BV) is the most common vaginal condition among reproductive-age women, yet it is often dismissed as a minor nuisance. This misconception ignores the …
Year:: 2026
Contributor:: Selamawi, Danait (creator); Mathiowitz, Edith (Advisor); Crego, Adam (Reader); Shukla,, Anita (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: drug delivery; bacterial vaginosis
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A Strategic Commercialization and Market Analysis for SomaCare

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Description:: Chronic pain affects an estimated 51.6 million adults in the United States, generating more than $600 billion in annual economic losses through healthcare expenditure, productivity …
Year:: 2026
Contributor:: Troth, Benjamin (creator); Petzschner, Frederike (Advisor); Huang, Eric (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: digital health
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Can LLMs Reliably Detect Complex Human Emotions such as Curiosity and Anxiety

Description:: College is a critical transitional period, and students spend much of it learning how to balance academic, personal, and financial responsibilities while adapting to daily …
Year:: 2026
Contributor:: Gandhi, Saachi (creator); Brewer, Judson (Advisor); Crego, Adam (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Anxiety; AI Healthcare; AI Bias; AI ethics; Curiosity; Psychometrics
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Gut Pathogen Replication in the Absence of NINJ and Gasdermin-Mediated Plasma Membrane Rupture

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Description:: This thesis investigates the in vivo role of plasma membrane rupture effectors including NINJ1, NINJ2, GSDMD, and GSDME in regulating enteric viral infection using genetically …
Year:: 2026
Contributor:: Zhou, Bingyue (creator); Beura, Lalit (Reader); Crego, Adam (Reader); Lee, Sanghyun (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Immunology
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Investigating the role of Aspartate β-Hydroxylase on the Epidermal Growth Factor Receptor pathway in Chondrosarcoma cell lines

Description:: Chondrosarcomas (CS) are the second most common malignant bone tumour and are difficult to treat because they are resistant to conventional types of treatment such …
Year:: 2026
Contributor:: Philip, Johann (creator); de la Monte, Suzanne (Advisor); Chen, Qian (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Biotechnology; Cancer; Cancer cells; Cancer cells--Motility
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Market Assessment and Commercialization Strategy for MBapp+

Description:: MBapp+ is a digital therapeutic smartphone app developed at the Women and Infants Hospital of Rhode Island under Dr. Adam Lewkowitz in collaboration with Brown …
Year:: 2025
Contributor:: Taneja, Saloni (creator); Lewkowitz, Adam (Advisor); Crego, Adam (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Therapeutic Sciences (sponsor)
Genre:: theses
Subject:: Commercialization; digital therapeutic; market assessment
Collection:: Biology and Medicine; Therapeutic Sciences

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Optimization of a hybrid multiplex human - Plasmodium falciparum targeted long-read sequencing panel and investigation of the Pfsa/hemoglobin coevolution in Mali

Description:: Malaria is the leading cause of mortality in children under the age of 5 in Mali, with Plasmodium falciparum accounting for 98% of severe infections. …
Year:: 2026
Contributor:: AlShaye, Alia (creator); Bailey, Jeffrey (Advisor); Niare, Karamoko (Advisor); Fola, Abebe (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Nanopore sequencing; Oxford Nanopore Technologies; Malaria; Plasmodium falciparum
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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PIM1 Kinase as a Regulator of Aggressive Phenotypes in Cancer: Effects of Pharmacological Inhibition on Cell Survival and the Tumor Microenvironment

Description:: Abstract of PIM1 Kinase as a Regulator of Aggressive Phenotypes in Cancer: Effects of Pharmacological Inhibition on Cell Survival and the Tumor Microenvironment, by Elizabeth …
Year:: 2026
Contributor:: Carrara, Elizabeth Agnello (creator); Lawler, Sean (Advisor); Horrigan, Diana (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Breast Cancer; cancer therapeutics; Brain Cancer
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Proteomic Analysis of Proximal Poly(ADP-Ribose)-Associated Protein Complexes In Response to DNA Damage and Replication Stress

Description:: Poly(ADP-ribose) (PAR) signaling, catalyzed by PARP1 and PARP2 at sites of DNA damage, serves as a critical sensor of base excision repair (BER) complex assembly. …
Year:: 2026
Contributor:: Krystyniak, Hayden Whitfield (creator); Sobol, Robert (Advisor); Roos, Wynand (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Cancer; DNA repair; Proteomics; DNA damage; poly-ADP-ribose (PAR), RNF146, WWE domain, Macrodomain, PAR binding domains, DNA damage; Proximity proteomics
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Quorum-Sensing Control of the Chromobacterium vaccinii Volatilome: A Molecular Genetic Study Enabled by Custom Image Analysis

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Description:: The quantification of microbial colony growth on solid media is currently compromised by a mismatch between the assumptions embedded in common biological image analysis tools …
Year:: 2026
Contributor:: Quarterone do Prado, Victor (creator); Nau, Gerard (Advisor); Cuomo, Christina (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Image analysis; Microbiology; Antibiotics--Research
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Transcriptomic Characterization of Chordoma with Functional Investigation of ErbB Signaling and Early-Stage 3D Organoid Optimization

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Description:: Chordoma is a rare cancer of notochordal origin with frequent recurrence and limited treatment options. To better understand recurrence-associated changes and oncogenesis in chordoma, this …
Year:: 2026
Contributor:: Shin, Leah (creator); Sullivan, Patricia (Advisor); Martinez-Moreno, Margot (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Chordoma; Organoid; ErbB
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Uncovering and Characterizing the Function and Utility of Human Norovirus NS1

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Description:: Abstract of Uncovering and Characterizing the Function and Utility of Human Norovirus NS1, by Vasisht Varma Poosapati, ScM, Brown University, May 2026. Human norovirus (hNoV) …
Year:: 2026
Contributor:: Poosapati, Vasisht Varma (creator); Lee, Sanghyun (Advisor); Oancea, Elena (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Immunology; Virology; Noroviruses
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Understanding the Role of Phospholipid Scramblase 1 in ILC2-Driven Type 2 Inflammation in Alternaria-Induced Asthma

Description:: Exaggerated type 2 immune responses play critical roles in the pathogenesis of allergic diseases, including asthma and atopic dermatitis. Recent studies have highlighted the importance …
Year:: 2026
Contributor:: Hou, Yuhan (creator); Zhou, Yang (Advisor); Oancea, Elena (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: PLSCR1; Type 2 Inflammation; Innate Lymphoid Cells (ILC2); Alternaria Alternata; Allergic Airway Inflammation; Atopic Dermatitis; Skin–Lung Immune Axis
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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