Background: Bacterial and fungal infections, generally common in critically ill patients with viral respiratory infections, may be common in patients with SARS-CoV-2 (the virus causing …
Staphylococcus aureus is a gram-positive antibiotic-resistant pathogen that poses a growing global health threat. Bacteria produce virulence factors, including hemolysins, and can form biofilm matrices …
The human microbiome contributes to a number of physiological processes, including digestion, neurological development, and proper immune function. Due to its central role in human …
Neutropenia and neutrophil dysfunction result in increased susceptibility to severe bacterial and fungal infections. Recently, we characterized conditionally-immortalized murine neutrophil progenitor cell lines (NPs) under …
The rise of antibiotic-resistant bacteria poses a threat to human health across the globe. In order to protect ourselves, it is imperative to identify novel …
The gut microbiome is the assemblage of symbiotic microbes inhabiting distinct ecological niches within the host that participate in key physiological functions such as energy …
Antibiotic therapy alters bacterial abundance and metabolism in the gut microbiome, leading to adverse health outcomes such as dysbiosis and opportunistic infections. Additionally, antibiotic effectiveness …
Sensory neurons have the unique ability to rapidly adapt their output in response to changes in their environment. Sensory nerve endings can become transiently or …
The innate and adaptive immune systems are often considered independent. The innate arm is generalized as broad and non-specific, while the adaptive arm more slowly …
Abstract of Role of Complement Cascade in Pathogenesis of Myeloproliferative Neoplasms, by Alissa Oakes, Ph.D., Brown University, June 2024 Chronic inflammation is a hallmark of …
Chemotherapy is one of the most effective breast cancer treatment strategies to date. However, a subtype of breast cancer cells, which were giant in size, …
Objective This research examines the alterations and potential resultant consequences of tobacco smoking on the human microbiome. Background Tobacco smoking is a risk factor for …
Vitamin A or retinol is amongst the most well characterized food-derived nutrient with diverse immune-modulatory roles. Deficiency in dietary vitamin A is associated with immune …
JC polyomavirus (JCPyV) is a small non-enveloped virus that establishes lifelong, persistent infections in the majority of the adult population. Immune-competent patients are generally asymptomatic, …
Human polyomaviruses are extremely successful viruses that can infect people early in life, evade the immune system for decades in a symbiotic relationship with their …