Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a …
CaV2.2 voltage-gated calcium channels (CaVs) are expressed at presynaptic terminals in most central and peripheral neurons where they control the calcium (Ca2+) entry that triggers …
Animal behavior is driven by perception of biological need and environmental context. Internal representations of the external world help us to interact with and navigate …
Early in the development of Xenopus laevis tadpoles, as the animals become capable of actively navigating their environment, individual neurons in the optic tectum become …
The thalamus is essential for normal brain function. The thalamus is widely interconnected with other brain areas, and is best known for relaying sensory information …
The thalamus is an important subcortical structure that relays afferent information to the neocortex, provides a pathway for corticocortical interaction, and plays key roles in …
Temperature is a fundamental property that affects all biologic systems, including the brain. The high temperatures of fever states can trigger febrile seizures in children, …
Work in the last ten years has demonstrated the existence of a third class of light-sensing neurons in the mammalian retina, intrinsically-photosensitive retinal ganglion cells …
For decades we have known that the medial temporal lobe (MTL), particularly the hippocampus, plays a critical role in the formation of episodic and spatial …
The α7 nicotinic acetylcholine receptor (α7 nAChR), a ligand-gated ion channel whose involvement in numerous neurological and somatic pathologies makes it a target of considerable …
Understanding how heterogenous subtypes of neurons in the brain are established during embryogenesis is a vital endeavor in modern neuroscience. In terms of development, a …
Exposure of human skin to solar ultraviolet radiation (UVR), a powerful carcinogen comprising ~95% UVA wavelengths (320-400 nm) and 5% UVB wavelengths (280-320 nm) at …
Voltage-gated calcium channels in neurons couple membrane depolarization to calcium-dependent processes, including activity-dependent gene expression and synaptic neurotransmitter release. In nociceptors, CaV2.2 channels are the …