In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Intravascular catheter related bloodstream infections are a leading cause of hospital-acquired nosocomial infections all over the world, which result in not only the burden of …
Bacterial infections can be difficult to treat and potentially lethal due to the rising global threat of antibiotic resistance. Systemic administration and overuse of antibiotics …
Staphylococcus aureus is a gram-positive antibiotic-resistant pathogen that poses a growing global health threat. Bacteria produce virulence factors, including hemolysins, and can form biofilm matrices …
The need to improve the longevity of orthopedic implants in vivo is increasingly important as the annual number of primary hip and knee replacements are …
Biofilm formation and drug resistance complicate the treatment of bacterial infections. These infections are comprised of bacteria with low metabolic activity, limiting the effects of …
Bacteria infections are the leading cause of patient mortality following injury. Conventional treatments include systemic delivery of broad-spectrum antibiotics. However, this leads to offsite toxicity …
Infections borne from the implantation of medical devices has continued to be a global health concern. Bacteria are capable of binding to the surfaces of …
There is a need for developing novel drug delivery systems (DDSs) to deliver therapeutics to desired sites with low toxicity. In this thesis we designed …
Stem cells have shown great promise for the treatment of human disease. However, stem cell therapies are limited by heterogeneous differentiation. As a result, researchers …
The placenta plays a crucial role during pregnancy, yet it remains one of the least understood human organs. Trophoblast cells comprise the placenta with functions …
Surgical site infections (SSIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) are one of the leading causes of avoidable patient complication (World Health Organization, 2018; Chiang, …
Abstract of β-Lactamase Responsive Delivery of Bacteriophages for the Treatment of Multidrug Resistant Pseudomonas aeruginosa, by Alison M Veintimilla, ScM, Brown University, May, 2022. Antibiotic …
Antibiotic resistance and the emergence of multidrug resistant bacteria poses a great public health threat and complicates treatment of infections. One of the most impactful …