Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This …
Glioblastoma stem cells (GSCs) possess self-renewal and tumor-initiating properties, making them a significant target for therapeutic intervention. The current standard therapy for glioblastoma (GBM) includes …
Abstract of Inhibition of HDAC7 Using RNAi As an Epigenetic- Based Therapy in Targeting Malignancies, by Ola Hassan, Ph.D., Brown University, May 2024. Class IIa …
Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children, with <10% surviving more than 2 years post-diagnosis. This tumor is inoperable …
Abstract of Observing the RNA Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase in Glioblastoma, by Melanie Anderson, ScM, Brown University, May 2023. Objective: The …
The identification and characterization of enhancer RNAs (eRNAs), a subset of non-coding RNA molecules, as key regulators in Glioblastoma Multiforme (GBM) is an actively growing …
In this study, we probe cellular models along the neuro/glial plasticity axis. In the central nervous system, we focus on glioblastoma and its highly plastic …