NAFLD affects more than one-quarter of adults worldwide with 60% in diabetic patients and 90% in obese people. Aspartate beta-hydroxylase (ASPH), an alpha-ketoglutarate dependent enzyme …
Aspartyl-asparaginyl-β-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). …
Approximately 300 million people worldwide live with chronic hepatitis B virus (HBV) infection, which greatly increases their risk for liver cirrhosis and cancer. HBV contributes …
Background: Chronic alcoholic liver disease is associated with hepatic insulin resistance, inflammation, oxidative and ER stress, mitochondrial dysfunction, and DNA damage. Peroxisome proliferator activated receptor …
Innate lymphoid cells (ILCs) are diverse innate lymphocytes that contribute to the immune response against pathogens and cancer cells, and play a variety of roles …
Checkpoint blockade therapy, which targets conserved negative regulators of immune cell activation that act as “checkpoint molecules” that govern the balance between inhibition and hyperactivation …
In 1977, Emmanuel Farber, Dennis Solt and Alan Medline reported carcinogen-induced hyperplastic lesions in a model of liver carcinogenesis. Lesions that grew following this protocol …