Aspartyl-asparaginyl-β-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). …
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated …
Polymeric nanoparticles loaded with insulin is a highly sought-after drug delivery system in the treatment of diabetes mellitus. The goal of this experiment is to …
The method of phase inversion nanoencapsulation was utilized to develop an oral insulin microsphere delivery system fabricated from poly(fumaric-co-sebacic anhydride) (p(FASA)). As particle uptake in …
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer death in the United States. Chronic …
The phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is essential for cell survival, growth, proliferation, and differentiation. It is highly conserved and …
Background: Elevated levels of biomarkers, including fasting blood glucose and insulin, can influence cancer risks. It is paramount to ascertain if there is a more …