Recent increases in the incidence of congenital (hypospadias, cryptorchidism) and adult-onset (testis germ cell cancer, lowered sperm counts) diseases of the male reproductive tract are …
Liver transplantation remains the standard of care for liver failure but is constrained by a shortage of organs. Fetal hepatic cell transplantation (HCT) offers a …
Head and neck squamous cell carcinomas form a heterogeneous group of cancers of the upper aerodigestive tract, arising from the surface epithelium of the oral …
There is a high demand for developing a computational platform for global analysis of position- specific sequence variation within HIV-1 subtypes. Undesirable probe designs can …
Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions …
Antimicrobial resistance poses a global challenge to human health that is only expected to increase without significant treatment innovations. Novel therapeutic strategies are needed for …
Toxicity testing is undergoing a revolution, as the reliance on animal models has resulted in a large backlog of chemicals that have not been adequately …
Trypanosomes are the causative agent of human African sleeping sickness and nagana in cattle. The bovine parasite, Trypanosoma brucei brucei (T. b. brucei), is unable …
Candida albicans is an opportunistic human fungal pathogen that can adapt to fluctuating host environments by both genetic and epigenetic mechanisms. In this study, the …
Abstract of ``Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis'' by Alysha E. Simmons, Ph.D., Brown University, October 2020 Pulmonary fibrosis is a chronic, …
The human polyomavirus BK is a clinically relevant virus that causes the diseases Polyomavirus Induced Nephropathy and Hemorrhagic Cystitis in immune suppressed kidney and bone …
The human body is host to a variety of microbiomes, communities of microorganisms known to affect human development and function. The lung microbiome, in contrast …
The GH18 gene family includes true chitinases (Cs) and chitinase-like proteins (CLPs). Chitinase 3-like-1 (CHI3L1) is a prototypic CLP and elevated CHI3L1 expression has been …
Due to the aggressiveness of TNBC and the relatively large proportion of reproductive-age women this disease afflicts, there is a critical need to develop novel …
The gut microbiome is essential for the maintenance of host health, and perturbations to the gut microbial community can lead to disease states. While antibiotics …
Metastatic colorectal cancer (mCRC) has a five-year relative survival rate of 14%. Most patients receive 5-FU (F) and folinic acid (FOL) combined with oxaliplatin (OX), …
Just as the phenotypically different cells that make up multicellular organisms are distributed in tissues with structures that embody specific functions, microbial cells with different …
The trypanosomatid Trypanosoma brucei and other closely-related parasites cause a broad range human illnesses that affect millions worldwide and lack effective treatment options. A conserved …
The human microbiome contributes to a number of physiological processes, including digestion, neurological development, and proper immune function. Due to its central role in human …
