Variation in genomes occurs in many forms, from single nucleotide changes to gains and losses of entire chromosomes. Large-scale rearrangements, called structural variants (SVs), are …
Ten years ago, the first RNA-seq study was published. Since then over 200 thousand RNA-seq studies have been published, spanning many different organisms, tissue types, …
This dissertation presents two experimental studies of DNA polymers inside nanofluidic devices with well-defined topographic features. Those features include square pits and rectangular trenches etched …
Cancer is a disease resulting from genomic mutations that occur during an individual's lifetime and cause the uncontrolled growth of a collection of cells into …
For most eukaryotic organisms, protein coding sequences are only a small portion of the genome. Much of the genome is made up of transposable elements, …
DNA replication initiates from any given origin at most once per cell cycle to ensure perfect duplication of the hereditary material. DNA re-replication occurs when …
Next generation sequencing (NGS) analysis, isolation and identification of rare cell events, analysis and characterization of extraction genetic material requires multiple use of manual steps …
Cancer is an evolutionary process where cells acquire somatic mutations over time. As a result of this process, tumors are often highly heterogeneous — containing …