Pathobiology Theses and Dissertations

Theses and Dissertations for the Pathobiology department.

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Items (1-20) out of 155 results

A Fetal Testis Xenograft Bioassay to Assess Human Susceptibility to Phthalate-Induced Endocrine Disruption

Description:: Recent increases in the incidence of congenital (hypospadias, cryptorchidism) and adult-onset (testis germ cell cancer, lowered sperm counts) diseases of the male reproductive tract are …
Year:: 2012
Contributor:: Heger, Nicholas E (creator); Boekelheide, Kim (Director); Hixon, Mary (Reader); Freiman, Richard (Reader); DePaepe, Monique (Reader); Howdeshell, Kembra (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: phthalate; endocrine disruption; Testis; Xenografts
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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A Multiomics Approach to Evaluate Advances in Liver Transplantation

Description:: Liver transplantation remains the standard of care for liver failure but is constrained by a shortage of organs. Fetal hepatic cell transplantation (HCT) offers a …
Year:: 2023
Contributor:: Ohman, Anders William (creator); Sanders, Jennifer (Advisor); Tapinos, Nikos (Reader); Reichner, Jonathan (Reader); Freiman, Richard (Reader); Uygun, Korkut (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Liver; Proteins--Analysis; Histones; multi-omic data; Liver--Transplantation; Fetal liver cells--Transplantation; Messenger RNA--Analysis
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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A role for microRNAs in the etiology of head and neck squamous cell carcinoma

Description:: Head and neck squamous cell carcinomas form a heterogeneous group of cancers of the upper aerodigestive tract, arising from the surface epithelium of the oral …
Year:: 2009
Contributor:: Avissar-Whiting, Michele (creator); Marsit, Carmen (director); Kane, Agnes (reader); Kelsey, Karl (reader); Hixon, Mary (reader); Chen, Jia (reader); Brown University. Division of Biology and Medicine. Pathobiology (sponsor)
Genre:: theses
Subject:: microRNA; head and neck cancer; Epigenetics
Language:: English
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Pathobiology; Theses and Dissertations

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A Thermodynamics-Based Algorithm for Optimizing HIV Drug Resistance Probe Designs

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Description:: There is a high demand for developing a computational platform for global analysis of position- specific sequence variation within HIV-1 subtypes. Undesirable probe designs can …
Year:: 2018
Contributor:: Lizbinski, Rico Leonardo (creator); Tripathi, Anubhav (Advisor); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: HIV/AIDS; Algorithms; Drug resistance; Thermodynamics; Probes
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Abstract of, “Regulation of Human Neutrophil Functions by the Integrin, CR3 – An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation” by Angel S. Byrd, Ph.D., Brown University, May 2014

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Description:: Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions …
Year:: 2014
Contributor:: Byrd, Angel Shree' (creator); Reichner, Jonathan (Director); Gruppuso, Philip (Reader); Sanders, Jennifer (Reader); Frackelton, A. Raymond (Reader); Salomon, Arthur (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: NEONATES; CGD; MYELOPOEISIS; ECM; and NETS; Newborn infants; Phagocytes; Granulocytes; Colegio de México
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Alzheimer's Disease Risk Factor BIN1 Promotes Extracellular Tau Release via Secretory Autophagy

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Description:: Bridging integrator 1 (BIN1) represents the second most significant genetic risk factor for sporadic Alzheimer’s disease (AD). While BIN1 risk variants correlate with tau pathology …
Year:: 2025
Contributor:: O'Rourke, Ryan Scott (creator); Huang, Alvin (Advisor); Lapierre, Louis (Reader); Atwood, Walter (Reader); Morrow, Eric (Reader); Huang, Eric (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Alzheimer's disease
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Antibiotic Resistance: Development and Dissemination in vitro and in the Marine Environment

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Description:: Antimicrobial resistance poses a global challenge to human health that is only expected to increase without significant treatment innovations. Novel therapeutic strategies are needed for …
Year:: 2022
Contributor:: Korry, Benjamin Joseph (creator); Belenky, Peter (Advisor); Fairbrother, William (Reader); Plavicki, Jessica (Reader); Weinreich, Daniel (Reader); Gomez-Chiarri, Marta (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Bacteria; Microbiology; microbiome; Antibiotics; Metagenomics; Metatranscriptomics; shotgun metagenomics; antimicrobial resistance; Microbial ecology (Environmental microbiology)
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Assessment of Morphologic and Molecular Effects of Estrogen Exposure Using MCF-7 3D Microtissues

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Description:: Toxicity testing is undergoing a revolution, as the reliance on animal models has resulted in a large backlog of chemicals that have not been adequately …
Year:: 2016
Contributor:: Vantangoli, Marguerite May (creator); Boekelheide, Kim (Director); Freiman, Richard (Reader); Kane, Agnes (Reader); Morgan, Jeffrey (Reader); Andersen, Melvin (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: endocrine disruption; three-dimensional cultures; microtissues; Toxicity testing; Estrogen
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Balancing Immune Checkpoints in Immune-Related Adverse Events: Lessons from NK and CD8+ T Cell Interactions in the Salivary Gland

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Description:: The increasing use of anti-PD-1 immune checkpoint blockade has led to the emergence of immune-related adverse events (irAEs). In this work, we investigated how the …
Year:: 2026
Contributor:: Borys, Samantha Michaela (creator); Beura, Lalit (Reader); Dubielecka-Szczerba, Patrycja (Reader); Atwood, Walter (Reader); Waggoner, Stephen (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Immunology; T cells; Cancer; Biology; Autoimmunity; Killer cells (Natural killer cells)
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Biogenesis of Trypanosome Lytic Factor and Mechanism of Trypanosome Killing

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Description:: Trypanosomes are the causative agent of human African sleeping sickness and nagana in cattle. The bovine parasite, Trypanosoma brucei brucei (T. b. brucei), is unable …
Year:: 2008
Contributor:: Widener, Justin W. (creator); Hajduk, Stephen (director); Bennet, Richard (reader); Campbell, Andrew (reader); Greenberg, Robert (reader); Nillni, Eduardo (reader); Brown University. Division of Biology and Medicine. Pathobiology (sponsor)
Genre:: theses
Subject:: Trypanosome; Trypanosome lytic Factor; Hemoglobin
Language:: English
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Pathobiology; Theses and Dissertations

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Cell State Switching in Candida albicans and Commensal Gut Adaptation

Description:: Candida albicans is an opportunistic human fungal pathogen that can adapt to fluctuating host environments by both genetic and epigenetic mechanisms. In this study, the …
Year:: 2021
Contributor:: Liang, Shen-Huan (creator); Bennett, Richard (Advisor); de Graffenried, Christopher (Reader); Belenky, Peter (Reader); Bliss, Joseph (Reader); Perez, J. Christian (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: epigenetics; Yeast fungi--Genetics; Mycology--Research; Gastrointestinal system; Infectious diseases
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

Full Record

Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis

Description:: Abstract of ``Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis'' by Alysha E. Simmons, Ph.D., Brown University, October 2020 Pulmonary fibrosis is a chronic, …
Year:: 2020
Contributor:: Simmons, Alysha (creator); Kane, Agnes (Advisor); Wong, Ian (Advisor); Morgan, Jeffrey (Reader); Hurt, Robert (Reader); Darling, Eric (Reader); Roxbury, Daniel (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: self-assembled spheroids; Image analysis; Nanomaterial; Fibrosis
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Characterization of BKPyV Interaction with Disialylated Gangliosides and PKC Regulated Viral Entry

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Description:: The human polyomavirus BK is a clinically relevant virus that causes the diseases Polyomavirus Induced Nephropathy and Hemorrhagic Cystitis in immune suppressed kidney and bone …
Year:: 2013
Contributor:: Allen, Stacy-ann A (creator); Atwood, Walter (Director); Reichner, Johnathan (Reader); Page, Rebecca (Reader); Shank, Peter (Reader); DiMaio, Daniel (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: receptor; signalling; Viruses
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Characterization of Macrophage Responses to Lung Microbiome Commensal Bacteria

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Description:: The human body is host to a variety of microbiomes, communities of microorganisms known to affect human development and function. The lung microbiome, in contrast …
Year:: 2020
Contributor:: Piatski, Marie E. (creator); Jamieson, Amanda (thesis advisor); Brown University. Molecular Microbiology and Immunology (sponsor)
Genre:: theses
Subject:: Bacteria; Macrophages; Lungs
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Characterization of the Pleiotropic Effects of the 36-Nucleotide Insertion Unique to Hepatitis B Virus Genotype G.

Description:: The pregenomic (pg) RNA of hepatitis B virus (HBV) serves as the template for translation of the core protein and the downstream P protein through …
Year:: 2012
Contributor:: Gutelius, Danielle M (creator); Tong, Shuping (Director); Atwood, Walter (Reader); Kurtis, Jonathan (Reader); Shank, Peter (Reader); Robek, Michael (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: genotype G; genome replication; pregenomic RNA; core promoter; protein translation; Hepatitis B virus
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Characterizing CHI3L1 Regulation of the Expression of Tumor Suppressor P53 and mutant EGFR in Non-Small Cell Lung Cancer

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Description:: The GH18 gene family includes true chitinases (Cs) and chitinase-like proteins (CLPs). Chitinase 3-like-1 (CHI3L1) is a prototypic CLP and elevated CHI3L1 expression has been …
Year:: 2023
Contributor:: Schor, Gail H (creator); Lee, Chun Geun (thesis advisor); Elias, Jack (thesis advisor); Kamle, Suchitra (reader); Brown University. Molecular Microbiology and Immunology (sponsor)
Genre:: theses
Subject:: Cancer; Lungs--Diseases
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Characterizing prognostic markers of response and reproductive implications of PD-1-based immunotherapy in triple negative breast cancer

Thumbnail for Characterizing prognostic markers …

Description:: Due to the aggressiveness of TNBC and the relatively large proportion of reproductive-age women this disease afflicts, there is a critical need to develop novel …
Year:: 2024
Contributor:: De La Cruz, Payton (creator); Freiman, Richard (Reader); Beura, Lalit (Reader); El-Deiry, Wafik (Reader); Grive, Kathryn (Advisor); James, Nicole (Advisor); Vanderhyden, Barbara (Reader); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Breast--Cancer; Cancer--Immunotherapy; Triple negative breast cancer
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Coffee Consumption Modulates Antibiotic- Induced Dysbiosis in the Murine Gut Microbiome

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Description:: The gut microbiome is essential for the maintenance of host health, and perturbations to the gut microbial community can lead to disease states. While antibiotics …
Year:: 2021
Contributor:: Hewlett, Katharine K. (creator); Belenky, Peter (thesis advisor); Vaishnava, Shipra (reader); Brown University. Molecular Microbiology and Immunology (sponsor)
Genre:: theses
Subject:: Microbiology; Antibiotics; Food--Microbiology; Caffeine
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Combination Chemotherapy Responses and Immune Modulation in Colorectal Cancer: Insights from Preclinical Models and Clinical Specimens

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Description:: Metastatic colorectal cancer (mCRC) has a five-year relative survival rate of 14%. Most patients receive 5-FU (F) and folinic acid (FOL) combined with oxaliplatin (OX), …
Year:: 2023
Contributor:: Carlsen, Lindsey (creator); Dubielecka-Szczerba, Patrycja (Reader); Zhitkovich, Anatoly (Reader); Tapinos, Nikos (Reader); Kopetz, Scott (Reader); El-Deiry, Wafik (Advisor); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: Cancer--Chemotherapy; Cancer--Immunotherapy; Colon (Anatomy)--Cancer
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization

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Description:: Just as the phenotypically different cells that make up multicellular organisms are distributed in tissues with structures that embody specific functions, microbial cells with different …
Year:: 2012
Contributor:: Valm, Alex Mihkel (creator); Oldenbourg, Rudolf (Director); Borisy, Gary (Director); Atwood, Walter (Reader); Reichner, Jonathan (Reader); Danuser, Gaudenz (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: fluorescence imaging; microbial communities; Spectral imaging
Language:: English
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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Pathobiology Theses and Dissertations

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Items (1-20) out of 155 results

Items (1-20) out of 155 results

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