Molecular Biology, Cell Biology, and Biochemistry Theses and Dissertations

Theses and Dissertations for the Molecular Biology, Cell Biology, and Biochemistry department.

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Items (1-20) out of 209 results

A BMP-dependent feedback loop regulates dpp expression by direct and indirect mechanisms in the Drosophila wing imaginal disc

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Description:: Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
Year:: 2012
Contributor:: Aldrich, Maryanna M (creator); Wharton, Kristi (Director); McKeown, Michael (Reader); Freiman, Richard (Reader); Johnson, Mark (Reader); Raftery, Laurel (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: BMP signaling; dpp; negative regulation; Min jin dang (China); Transcription; Drosophila
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Macrophage Rac1-IL1B Signaling Axis Directs Atherosclerotic Calcification

Description:: Atherosclerotic plaque calcification is associated increased risk of cardiovascular events. Inflammation plays a key role in the development of atherosclerosis and is thought to potentially …
Year:: 2020
Contributor:: Berus, Joshua (creator); Morrison, Alan (Advisor); Wessel, Gary (Reader); Johnson, Mark (Reader); Wharton, Kristi (Reader); Chun, Hyung (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Atherosclerotic cardiovascular disease; Macrophages; Calcification
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A mechanistic analysis of Trypanosomatid cell division

Description:: Cytokinesis is an essential process for the proliferation of eukaryotic species. However, our knowledge of how a eukaryotic cell accomplishes cytokinesis is relegated to a …
Year:: 2023
Contributor:: Campbell, Paul Charles (creator); de Graffenried, Christopher (Advisor); Liu, Judy (Reader); Mowry, Kimberly (Reader); Atwood, Walter (Reader); Etheridge, Ronald (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Cytology; Molecular biology; Biochemistry; Cytoskeleton
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Mutagenic Screen Identifies Jim as a Regulator of Transposition, Heterochromatin, and Aging

Description:: Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Year:: 2020
Contributor:: Liu, Julianna J. (creator); Helfand, Stephen (thesis advisor); Lawrence, Charles (reader); Taylor, Jackson (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster; Genetics; Aging; Transposons; Heterochromatin; Chromatin; Gene silencing; Zinc-finger proteins
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Natural Role for Mitochondrial Double-stranded RNA in Gametogenesis: Implications for Disease

Description:: TDP-43 is a highly conserved RNA/DNA-binding protein known for its pathological role in neurodegenerative disease. However, TDP-43 is essential in many cell types beyond the …
Year:: 2025
Contributor:: St. Amand, Victoria Rose (creator); Accornero, Federica (Reader); Morrow, Eric (Reader); Valdez, Gregorio (Reader); Yamashita, Yukiko (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Mitochondria; TDP-43; Spermatogenesis; Drosophila; Double-stranded RNA
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

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A New Model of Amyotrophic Lateral Sclerosis in Drosophila melanogaster: Precise Genetic Engineering, Characterization and Genetic Suppression

Description:: ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Year:: 2015
Contributor:: Sahin, Asli (creator); Reenan, Robert (Director); Fallon, Justin (Reader); Hart, Anne (Reader); Wharton, Kristi (Reader); Bonini, Nancy (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: ALS; Motor neuron; Disease; neurodegeneration; homologous recombination; ems; genetic screen; Drosophila; Genetic engineering
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Quantitative Phosphoproteomic Analysis of the T-Cell Receptor Signaling Pathway Using Novel High-Throughput Approaches

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Description:: Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
Year:: 2011
Contributor:: Nguyen, Vinh Hai (creator); Salomon, Arthur (Director); Brossay, Laurent (Reader); Wessel, Gary (Reader); Gruppuso, Philip (Reader); Sauer, Karsten (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: mass spectometry; TCR signaling; Jurkat T-cells; SILAC; label-free; hybrid quantitative approach; Zap-70; FYN regulation; method development; ERK positive feedback
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A-to-I RNA Editing of Voltage-Gated Potassium Channels: Regulation and Functional Consequences in Drosophila melanogaster.

Description:: A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
Year:: 2011
Contributor:: Maloney, Rachel A (creator); Reenan, Robert (Director); McKeown, Michael (Reader); Fairbrother, William (Reader); Lipscombe, Diane (Reader); Rogina, Blanka (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: RNA editing; Potassium channels; Drosophila
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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An Evolutionary Analysis of Sex and Reproductive Biology “Go Nads! A Partnership of the Germline and Soma”

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Description:: Sex determination is an essential, and highly variable process, of organismal development. Looking for common threads used in evolution to determine sex is difficult simply …
Year:: 2023
Contributor:: Pieplow, Cosmo Apollo (creator); Freiman, Richard (Reader); DeLong, Alison (Reader); Larschan, Erica (Reader); Liu, Judy (Reader); Capel, Blanche (Reader); Wessel, Gary (Advisor); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Sex determination, Genetic; Echinodermata; Germ cells; Reproduction; Sex differences; primordial germ cells; Sex differentiation
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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An Exploration of the Estrogen Pathway in Sea Urchin Ovaries

Description:: Sex steroids are essential in many reproductive systems, and are involved in development of secondary sexual characteristics, gonadal maturation, germ cell proliferation, and sexual behavior. …
Year:: 2023
Contributor:: Min Sung Ellie Kim (creator); Wessel, Gary (thesis advisor); Oulhen, Nathalie (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Estrogen; Ovaries; Sea urchins
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

Available to Brown-affiliated users only

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An Investigation of miRNA Repertoires in Bdelloid Rotifers

Description:: An exceptional group of aquatic invertebrates makes up Class Bdelloidea. Bdelloid rotifers are the only group of ancient asexual animals known. A second distinction that …
Year:: 2013
Contributor:: Dutta, Anupriya (creator); Mark Welch, David (Director); Mckeown, Michael (Reader); Bennett, Richard (Reader); Arkhipova, Irina (Reader); Chen, Kevin (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: miRNAs; microRNAs; rotifers; bdelloid rotifers; let-7; miR-100; miRNA editing; Evolution; Rotifera; RNA editing
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Analysis of Age and Sex-Specific Differences in Gene and pri-miRNA Expression in the Cell-Types of the Mus Musculus Subventricular Zone

Description:: Neurogenesis sharply declines with age in the subventricular zone (SVZ). The SVZ niche contains multipotent neural stem cells (NSCs) that can differentiate into neurons, astrocytes, …
Year:: 2022
Contributor:: Elias, Amy Elizabeth (creator); Sedivy, John (Reader); Webb, Ashley (Reader); Freiman, Richard (Reader); Kreiling, Jill (Advisor); Suh, Yousin (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: miRNA; Aging; Neural stem cells; single-nucleus sequencing; subventricular zone
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Analysis of Endoderm Patterning and Pancreatic Organogenesis in Xenopus laevis

Description:: The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
Year:: 2014
Contributor:: Bilogan, Cassandra K (creator); Horb, Marko (Director); Wessel, Gary (Reader); Mowry, Kimberly (Reader); Wharton, Kristi (Reader); He, Xi (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: Endoderm; Staufen2; Ptf1a; Development; Xenopus; Economic development; Pancreas
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Analysis of Secreted Enzymes, Metabolism and Virulence in the Bat Fungal Pathogen Pseudogymnoascus destructans

Description:: Pseudogymnoascus destructans is the invasive fungal pathogen responsible for White-Nose Syndrome (WNS), a devastating disease affecting North American bats. WNS has led to the loss …
Year:: 2019
Contributor:: Beekman, Chapman (creator); Bennett, Richard J. (Advisor); DeLong, Alison (Reader); Johnson, Mark (Reader); Belenky, Peter (Reader); Cramer, Robert A., Jr, (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Metabolism; Bats; Fungi; Virulence (Microbiology); Peptidase; White-nose Syndrome; pathogenicity
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Analyzing the effects of transcriptional regulation on phenotypic switching within Candida albicans yeast

Description:: Eukaryotic organisms undergo changes in morphology in order to survive and proliferate within a variety of different environments and conditions. The human fungal pathogen Candida …
Year:: 2022
Contributor:: Homayoon, Ameen Arshan (creator); Bennett, Richard (Advisor); Belenky, Peter (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Candida albicans; Gene regulatory networks; Fungi--Genetics
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Atomistic Insights into the Regulation of a Thermophilic CRISPR-Cas9 by Anti-CRISPR and Intrinsic Protein Dynamics

Description:: The intuitive manipulation of specific amino acids or binding of exogenous ligands to alter the activity or specificity of CRISPR-Cas9 has been a topic of …
Year:: 2026
Contributor:: Knight, Alexa Loretta (creator); Johnson, Mark (Reader); Delaney, Sarah (Reader); Larschan, Erica (Reader); Jogl, Gerwald (Advisor); Lisi, George (Advisor); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Biophysics; Crystallography; Structural biology; NMR
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Behaviour of Ovarian Cancer Cells in 2D and 3D Under Adherent and Non-Adherent Conditions

Description:: High Grade Serous Carcinoma (HGSC) is the deadliest form of ovarian cancer among women and causes the most deaths of gynaecological cancers overall (Tudrej, Patrycja …
Year:: 2019
Contributor:: Niewchas, Abbigail E. (creator); Freiman, Richard (thesis advisor); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Cancer; Ovarian; BRCA genes; TAF
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Biological Consequences of Specific and Promiscuous A-to-I RNA Editing Revealed Through Precise Genetic Engineering.

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Description:: In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination …
Year:: 2011
Contributor:: Savva, Yiannis A (creator); Reenan, Robert (Director); McKeown, Michael (Reader); Johnson, Mark (Reader); Bender, Judith (Reader); Carmichael, Gordon (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: RNA editing
Language:: English
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Biophysical Analysis of the Primary Nucleic Acid Binding Domains of HsLINE-1 ORF1p

Description:: Abstract of Biophysical Analysis of the Primary Nucleic Acid Binding Domains of HsLINE-1 ORF1p, by Raphael Britt, Ph.D., Brown University, May 2026. Long Interspersed Nuclear …
Year:: 2026
Contributor:: Britt, Raphael Isaiah (creator); Sedivy, John (Advisor); Jogl, Gerwald (Advisor); Lisi, George (Reader); Atwood, Walter (Reader); Larschan, Erica (Reader); LaCava, John (Reader); Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: retrotransposon; LINE-1; Retrotransposition; Protein Nucleic Acid Interaction; ORF1p
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Cardiovascular response to peer rejection as a biomarker for adolescent depression risk

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Description:: This study assessed how cardiovascular measures and cardiovascular reactivity differ between physically healthy adolescent girls diagnosed with major depressive disorder (MDD), those at high risk …
Year:: 2016
Contributor:: Speakman, Rachel (author); Stroud, Laura (advisor); Zielinski-Habershaw, Beth (reader)
Genre:: theses
Subject:: Mental depression; Cardiovascular system; Heart beat; Blood pressure
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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Molecular Biology, Cell Biology, and Biochemistry Theses and Dissertations

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