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Cardiovascular response to peer rejection as a biomarker for adolescent depression risk


This study assessed how cardiovascular measures and cardiovascular reactivity differ between physically healthy adolescent girls diagnosed with major depressive disorder (MDD), those at high risk for MDD, and control girls with no personal or family history of psychiatric conditions, both at baseline and in response to a social exclusion paradigm. Eighty-four female children and adolescents ages ten to eighteen completed the Yale Interpersonal Stressor-Child version (YIPS-C), a laboratory social exclusion paradigm. Systolic, diastolic, mean arterial blood pressure (SBP, DBP, MAP), and heart rate (HR) were assessed at throughout the stress session during baseline, stress, and recovery periods using an oscillometric device. Reactivity was calculated as percent change in blood pressure or HR from rest to social stressor, by subtracting the mean baseline measurement from the mean stressor measurement (Introduction, Conversation, or Recovery), and then dividing by the mean baseline measurement. MDD girls showed higher overall mean SBP, DBP, and MAP, as well as lower overall HR throughout the session versus high risk and control girls. MDD girls also showed higher DBP and MAP reactivity versus high risk and control girls, respectively. SBP, DBP, MAP, and HR in high risk girls more closely resembled control girls than girls with MDD throughout the session; cardiovascular reactivity of DBP and MAP of high risk girls was intermediate between control girls and MDD girls. In conclusion, it was found that high DBP both at baseline and in response to social stressors may be a potential biomarker for adolescent depression risk.
Concentration: Biology (ScB)/Physiology and Biotechnology

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Speakman, Rachel, "Cardiovascular response to peer rejection as a biomarker for adolescent depression risk" (2016). Biology and Medicine Theses and Dissertations, Molecular Biology, Cell Biology, and Biochemistry Theses and Dissertations. Brown Digital Repository. Brown University Library.