Biotechnology

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Items (1-20) out of 48 results

2741-19 in combination with piperaquine as next generation therapy against P. falciparum

Description:: Introduction: Malaria, caused by the Plasmodium parasite, is a leading cause of mortality in sub-Saharan Africa, disproportionately affecting children under the age of 5. The …
Year:: 2026
Contributor:: Skinner, Brooke (creator); Kurtis, Jonathan (Advisor); Wu, Hannah (Reader); Najrana, Tanbir (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Blood-stage malaria; Antimalarials
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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A 3D In Vitro Ring Model with Macrophage and Fibroblast Co-culture: A Platform for Preclinical Fibrosis Studies as an Alternative to Animal Testing

Description:: Abstract This study presents a scaffold-free 3D ring-shaped co-culture model composed of human dermal fibroblasts and THP-1 monocyte-derived macrophages to recapitulate cellular interactions associated with …
Year:: 2026
Contributor:: Kim, Yaunghyun (creator); Morgan, Jeffrey (Advisor); Raimondo, Theresa (Advisor); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: tissue engineering; Fibroblasts; Fibrosis; Macrophages; 3D in vitro models; 3D tissue engineering
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A NOVEL DUAL-FUNCTION PLATFORM FOR THE TREATMENT OF RECURRENT BACTERIAL VAGINOSIS (BV)

Description:: Bacterial vaginosis (BV) is the most common vaginal condition among reproductive-age women, yet it is often dismissed as a minor nuisance. This misconception ignores the …
Year:: 2026
Contributor:: Selamawi, Danait (creator); Mathiowitz, Edith (Advisor); Crego, Adam (Reader); Shukla,, Anita (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: drug delivery; bacterial vaginosis
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A Strategic Commercialization and Market Analysis for SomaCare

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Description:: Chronic pain affects an estimated 51.6 million adults in the United States, generating more than $600 billion in annual economic losses through healthcare expenditure, productivity …
Year:: 2026
Contributor:: Troth, Benjamin (creator); Petzschner, Frederike (Advisor); Huang, Eric (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: digital health
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Can LLMs Reliably Detect Complex Human Emotions such as Curiosity and Anxiety

Description:: College is a critical transitional period, and students spend much of it learning how to balance academic, personal, and financial responsibilities while adapting to daily …
Year:: 2026
Contributor:: Gandhi, Saachi (creator); Brewer, Judson (Advisor); Crego, Adam (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Anxiety; AI Healthcare; AI Bias; AI ethics; Curiosity; Psychometrics
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Characterization of PARG Inhibitors and Their Effects on DNA Damage, Repair, and Survival in +/- HRD Cancers

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Description:: Ovarian cancer remains a significant clinical gap due to late-stage diagnosis and frequent development of resistance to standard therapies, including platinum-based chemotherapy and PARP inhibitors. …
Year:: 2026
Contributor:: Magro, Emelia (creator); Sobol, Robert W (Advisor); Roos, Wynand (Reader); Horrigan, Diana (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: ovarian cancer; GBM, Glioblastoma, PARG inhibiton, PAR, DNA, DNA Damage and Repair, SSBR, BIA, CHk1 inhibtion, TMZ
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Characterization of the Novel Antimalarial 2741-19: Barrier to Resistance and Stage-Specific Activity

Description:: Malaria imposes an immense global health burden, and remains a significant driver of child mortality in sub-Saharan Africa. The emergence and spread of parasite strains …
Year:: 2026
Contributor:: Chan, Michael (creator); Kurtis, Jonathan (Advisor); Najrana, Tanbir (Reader); Wu, Hannah (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Malaria; Drug development; antimicrobial resistance; Plasmodium falciparum; PfGARP; Antimalarials
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Characterizing Choice Behavior in Drosophila Olfactory Classical Conditioning

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Description:: Drosophila melanogaster is a powerful model organism to understand the neural and molecular mechanisms underlying learning and memory. However, memory is usually studied by assessing …
Year:: 2026
Contributor:: Stea, Samuel Giovanni (creator); Kaun, Karla (Advisor); Aizenman, Carlos (Reader); O'Connor-Giles, Kate (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Drosophila--Behavior
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Characterizing the Genomic and Metabolic Factors Governing CHROMagar Pigmentation in Candida albicans

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Description:: Candida albicans is a major opportunistic fungal pathogen known for its remarkable phenotypic plasticity, which aids in its survival within diverse host environments. While CHROMagar …
Year:: 2026
Contributor:: Wu, Zhenyuan (creator); Bennett, Richard (Advisor); Cuomo, Christina (Reader); Belenky, Peter (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Genetics; Genomics; Microbiology; Candida albicans; Candida; Mycology
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Chromosome 1 Aneuploidy Regulates White–Opaque Switching in Candida albicans

Description:: Candida albicans is a major human fungal pathogen capable of undergoing white-opaque phenotypic switching, a stable, heritable, and reversible transition between two distinct cell states …
Year:: 2026
Contributor:: Maharjan, Kritika (creator); Horrigan, Diana (Reader); Cuomo, Christina (Reader); Bennett, Richard (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Candida albicans; White-opaque switching; Chromosomal aneuploidy
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Circulating Metabolites as Probes for Luminal Transport Mechanisms in the Gut

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Description:: The intestinal epithelium serves as a critical interface between host circulation and the gut lumen, yet the extent to which host-derived metabolites traverse this barrier …
Year:: 2026
Contributor:: Magana Miralles, Dana (creator); Chellappa, Karthikeyani (Advisor); Dugan, Aisling (Reader); Toth, Chuck (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Microbial metabolism; Gut lumen; Nicotinamide
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Differential Effects of Base Excision Repair Factor Depletion on Cellular Sensitivity to PARG Inhibition in Ovarian Cancer Cells

Description:: Base excision repair (BER) is a critical DNA repair pathway that resolves base and single-strand DNA damage to help maintain genomic stability. Key BER proteins …
Year:: 2026
Contributor:: He, Zhiying (creator); Sobol, Robert (Advisor); Mathiowitz, Edith (Reader); Huang, Eric (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Ovarian Cancer Cells
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Differential Effects of Proinflammatory Cytokines on TGF-β1-Mediated Biomechanical and Biochemical Properties of 3D Human Fibroblast Tissues

Description:: Fibrosis is driven by excessive extracellular matrix (ECM) deposition and is a hallmark of chronic diseases including pulmonary fibrosis, liver cirrhosis, and cardiac fibrosis. TGF-β1 …
Year:: 2026
Contributor:: St. Angelo, Katerina (creator); Morgan, Jeffrey (Advisor); Horrigan, Diana (Reader); Y. Schell,, Jacquelyn (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: microtissue; Fibrosis; 3D Cell Culture; 3D cel ring model
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Discovery and Characterization of AP Endonuclease 1 Small Molecule Inhibitors: Impact on DNA Repair and Cancer Cell Viability

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Description:: Apurinic/Apyrimidinic Endonuclease 1 (APE1) is a multifunctional protein that plays critical roles in base excision repair (BER), redox regulation of transcription factors, and RNA processing. …
Year:: 2026
Contributor:: Wu, Hongmei (creator); Sobol, Robert (Advisor); Roos, Wynand (Reader); Horrigan, Diana (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: DNA repair; Novel anti-cancer small molecules; APE1
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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DNA Methylation of Neurodevelopmental, Stress-Response, Reward and Opioid Pathway Genes in Infants with Neonatal Opioid Exposure: Exploration of Sex-Specific Associations

Description:: DNA Methylation of Neurodevelopmental, Stress-Response, Reward and Opioid Pathway Genes in Infants with Neonatal Opioid Exposure: Exploration of Sex-Specific Associations
Year:: 2026
Contributor:: Aragon Vasquez, Angelica (creator); Lester, Barry M (Advisor); Camerota, Marie (Advisor); Coyle, Mara G (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: epigenetics; DNA--Methylation; neonatal opioid withdrawal syndrome
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Effects of Processing and Drug Loading on Morphology and Drug Release in PCL–Rifampicin Systems

Description:: This study examines how processing conditions regulate polymer morphology and mesophase formation in poly(caprolactone) (PCL) and how these structural transitions govern rifampicin release behavior. Demonstrating …
Year:: 2026
Contributor:: George, Susan (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Drug delivery systems; mesophase; biodegradable polymers
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Epidermal Growth Factor Receptor (EGFR) Regulation of Human Mo3.13 Oligodendrocytes and Its Impairment in Fetal Alcohol Spectrum Disorder

Description:: Fetal alcohol spectrum disorder (FASD) is associated with a range of structural and functional developmental abnormalities in the central nervous system. Recent research has highlighted …
Year:: 2026
Contributor:: Li, Alex (creator); de la Monte, Suzanne (Advisor); kaun, Karla (Reader); Valdez, Gregorio (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Myelination; Epidermal growth factor; Oligodendrocyte; Notch effect
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Evaluating 3D In Vitro Models for Translational Relevance: From Spheroid Architecture to Clinically Relevant Potency

Description:: Abstract of “Evaluating 3D In Vitro Models for Translational Relevance: From Spheroid Architecture to Clinically Relevant Potency” by Yiyin Chen, Sc.M in Biotechnology, Brown University, …
Year:: 2026
Contributor:: Chen, Yiyin (creator); Tripathi, Anubhav (Advisor); Lawler, Sean (Reader); Raimondo, Theresa (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: 3D Cell Culture; Organoid; Solid Tumor; RNA Therapeutics; Potency Assays; Translational Models; HepG2 Spheroids; Hepatotoxicology
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Event-Related Potential Markers of Emotional Provocation in Obsessive-Compulsive Disorder: A Centroparietal LPP Analysis

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Description:: Abstract of Event-Related Potential Markers of Emotional Provocation in Obsessive-Compulsive Disorder: A Centroparietal LPP Analysis, by Julia Aloi, ScM., Brown University, May 2026. This study …
Year:: 2026
Contributor:: Aloi, Julia (creator); McLaughlin, Nicole (Advisor); Fedorenko, Erick (Advisor); Crego, Adam (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: biomarker; Obsessive-compulsive disorder; EEG biomarker; Evoked potentials (Electrophysiology); Electroencephalography (EEG); emotional processing; Neuropsychiatry
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Gilding the Thread of Life: Proposing a Polymeric Drug Delivery System for Sustained Therapeutic Administration of Klotho Proteins

Description:: In the past 125 years, socio-economic developments and advancements in medicine and healthcare systems have contributed to a more than doubling of global human life …
Year:: 2026
Contributor:: Keuning, Floor (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Polymeric drug delivery systems
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Biotechnology

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Items (1-20) out of 48 results

Items (1-20) out of 48 results

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