Biotechnology

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Items (1-20) out of 151 results

2741-19 in combination with piperaquine as next generation therapy against P. falciparum

Description:: Introduction: Malaria, caused by the Plasmodium parasite, is a leading cause of mortality in sub-Saharan Africa, disproportionately affecting children under the age of 5. The …
Year:: 2026
Contributor:: Skinner, Brooke (creator); Kurtis, Jonathan (Advisor); Wu, Hannah (Reader); Najrana, Tanbir (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Blood-stage malaria; Antimalarials
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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A 3D In Vitro Ring Model with Macrophage and Fibroblast Co-culture: A Platform for Preclinical Fibrosis Studies as an Alternative to Animal Testing

Description:: Abstract This study presents a scaffold-free 3D ring-shaped co-culture model composed of human dermal fibroblasts and THP-1 monocyte-derived macrophages to recapitulate cellular interactions associated with …
Year:: 2026
Contributor:: Kim, Yaunghyun (creator); Morgan, Jeffrey (Advisor); Raimondo, Theresa (Advisor); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: tissue engineering; Fibroblasts; Fibrosis; Macrophages; 3D in vitro models; 3D tissue engineering
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A Deep Learning Method Predicting Lung Adenocarcinoma Recurrence: Binary and Time-Based Approaches

Description:: Despite advances in early detection and therapy, lung cancer is the leading cause of cancer death in the United States and accounts for approximately one-quarter …
Year:: 2025
Contributor:: Hayek, Karma (creator); Uzun, Ece (Advisor); Warner, Jeremy (Reader); Chen, Elizabeth (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Oncology; Deep Learning
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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A NOVEL DUAL-FUNCTION PLATFORM FOR THE TREATMENT OF RECURRENT BACTERIAL VAGINOSIS (BV)

Description:: Bacterial vaginosis (BV) is the most common vaginal condition among reproductive-age women, yet it is often dismissed as a minor nuisance. This misconception ignores the …
Year:: 2026
Contributor:: Selamawi, Danait (creator); Mathiowitz, Edith (Advisor); Crego, Adam (Reader); Shukla,, Anita (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: drug delivery; bacterial vaginosis
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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A Strategic Commercialization and Market Analysis for SomaCare

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Description:: Chronic pain affects an estimated 51.6 million adults in the United States, generating more than $600 billion in annual economic losses through healthcare expenditure, productivity …
Year:: 2026
Contributor:: Troth, Benjamin (creator); Petzschner, Frederike (Advisor); Huang, Eric (Reader); Crego, Adam (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: digital health
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Aging Impairs VEGF-A mRNA Stability and Consequent Inflammatory Arteriogenesis

Description:: Abstract: Aging impairs VEGF-A mRNA stability and consequent inflammatory arteriogenesis, by Olivya Caballero, Sc.M, Brown University, May, 2024. Objective: Aging is associated with impaired inflammatory …
Year:: 2024
Contributor:: Caballero, Olivya (creator); Morrison, Alan (Advisor); Mantsounga, Chris (Reader); Oancea, Elena (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Inflammation; Aging; Angiogenesis
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Alcohol-related White Matter Degeneration: Mechanistic Dysregulation and Exosome Detection

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Description:: Introduction: One of the major long-term consequences of chronic heavy or binge alcohol misuse is alcohol-related brain disease (ARBD) leading to neurocognitive and neurobehavioral dysfunction, …
Year:: 2024
Contributor:: Yang, Yiwen (creator); Zimmerman, Anita (Reader); de la Monte, Suzanne (Advisor); Feng, Jun (Reader); Kaun, Karla (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Alcohol; Neurodegeneration
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Analytical Study Using PLM, XRD, And ATR On The Morphology And Drug Release Potential Of Film Casted, Cold Pressed, And Heat Pressed Poly (L-lactic acid) And Curcumin

Description:: This paper illustrated the analytical study using PLM, XRD and ATR for the morphology and drug release potential of film casted, first pressed and heat …
Year:: 2023
Contributor:: Chen, Zihao (creator); Mathiowitz, Edith (Advisor); Schell, Jacquelyn (Reader); Chen, Qian (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Biotechnology; Biomaterials
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Aneuploidy of Chromosome R Regulates Candida albicans Colony Color Variations on CHROMagar Media

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Description:: Candidiasis is caused by fungi of the Candida genus and can range from mild to life-threatening systemic infections. In the United States, Candida bloodstream infections …
Year:: 2025
Contributor:: Yin, dannie (creator); Bennett, Richard (Advisor); Cuomo, Christina (Reader); Belenky, Peter (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Candida albicans; Aneuploidy; antifungals; CHROMagar
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Anti-PfGBP130 Antibodies Inhibit P. falciparum Growth In vitro

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Description:: Despite decades of effort to develop an effective vaccine against Plasmodium falciparum, malaria remains one of the deadliest diseases in modern times, claiming about 608,000 …
Year:: 2024
Contributor:: Johnson, Yannick Ekema (creator); Wu, Hannah (Reader); Najrana, Tanbir (Reader); Kurtis, Jonathan (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Malaria vaccine; Blood-stage malaria; mRNA; Growth Inhibiting Activity
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Artemisinin Resistance in Africa: Plasmodium falciparum kelch13 R561H spread and emergence of other artemisinin partial resistance mutations in Rwanda

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Description:: First detected in Rwanda, recent monitoring has detected multiple emerging Plasmodium falciparum kelch13 (K13) propeller gene mutations across East Africa. Mutations, such as R561H in …
Year:: 2023
Contributor:: Wernsman Young, Neeva Nicole (creator); Bailey, Jeffrey (Advisor); Simkin, Alfred (Reader); Fairbrother, William (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Malaria; Rwanda; Malaria modelling; kelch; Plasmodium falciparum
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Biochemical and Structural Features of Biotechnology

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Description:: Liquid-liquid phase separation (LLPS) has been rapidly gaining acceptance as a powerful mechanism to explain the formation of membrane-less organelles and their function, playing a …
Year:: 2025
Contributor:: Johnson, Victoria (creator); Fawzi, Nicolas (Advisor); Lisi, George (Reader); Naik, Mandar (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: liquid-liquid phase separation; Structural biology; RNA-protein interactions; Protein-protein interactions; Biomolecular condensates
Collection:: Biology and Medicine; Biotechnology

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Biomechanics of Paclitaxel-Induced Polyploid Giant Cancer Cells in Murine Breast Cancer

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Description:: This study explored the impact of extracellular matrix (ECM) stiffness on lipid metabolism in polyploid giant cancer cells (PGCCs) and their role in breast cancer …
Year:: 2024
Contributor:: Li, Yanxi (creator); Dawson, Michelle (Advisor); Oancea, Elena (Reader); Schell, Jacquelyn (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Breast Cancer
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Biophysical Simulations for Effective Neuropharmacology Treatment: A Market Analysis and Commercialization Strategy for the Human Neocortical Neurosolver

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Description:: Drug development within the pharmaceutical industry has historically proven to be a challenging feat. Investigational drug trials have a 90% failure rate due to adverse …
Year:: 2025
Contributor:: Hohil, Adrianna Adela (creator); Holmander, Daniel (Reader); Huang, Eric (Reader); Jones, Stephanie (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Software; Computational neuroscience; Evoked potentials (Electrophysiology); Simulations; Commercialization
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Biophysical Simulations for Effective Neuropharmacology Treatment: A Market Analysis and Commercialization Strategy for the Human Neocortical Neurosolver

Description:: Drug development within the pharmaceutical industry has historically proven to be a challenging feat. Investigational drug trials have a 90% failure rate due to adverse …
Year:: 2025
Contributor:: Hohil, Adrianna Adela (creator); Holmander, Daniel (Reader); Huang, Eric (Reader); Jones, Stephanie (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Electroencephalography; Computational neuroscience; EEG biomarker; Neuroscience; Commercialization
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Bystander Sensing of Norovirus Infection and Viral Counteraction

Description:: Noroviruses are the leading cause of acute gastroenteritis worldwide and are responsible for substantial economic losses every year. Their remarkable ability to evade host immunity …
Year:: 2025
Contributor:: Chee, Hsien Yao (creator); Lee, Sanghyun (Advisor); Beura, Lalit (Reader); Oancea, Elena (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Natural immunity; Noroviruses; antiviral immune response; MDA5
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Can LLMs Reliably Detect Complex Human Emotions such as Curiosity and Anxiety

Description:: College is a critical transitional period, and students spend much of it learning how to balance academic, personal, and financial responsibilities while adapting to daily …
Year:: 2026
Contributor:: Gandhi, Saachi (creator); Brewer, Judson (Advisor); Crego, Adam (Reader); Jong, Yong (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Anxiety; AI Healthcare; AI Bias; AI ethics; Curiosity; Psychometrics
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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cGAS-STING Agonist as a Therapeutic Target for Pediatric High Grade Glioma

Description:: Objective: Pediatric high-grade gliomas are among the most aggressive pediatric malignancies, associated with poor prognosis and limited therapeutic options. This study evaluates the therapeutic potential …
Year:: 2025
Contributor:: Hawkins, William Moriarty (creator); Lawler, Sean (Advisor); Oancea, Elena (Reader); Mathiowitz, Edith (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Pediatrics; Brain--Cancer
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Characterization and Genetic Modulation of Drosophila melanogaster Models of Amyotrophic Lateral Sclerosis

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Description:: Amyotrophic lateral sclerosis (ALS) is a rapidly-progressive and fatal neurodegenerative disease, characterized by the loss of motor neurons. Existing treatments are scarce and only extend …
Year:: 2023
Contributor:: Twinney, Sarah (creator); Horrigan, Diana (Reader); Rand, David (Reader); Wharton, Kristi (Advisor); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster; Amyotrophic lateral sclerosis; TDP-43; Neurodegeneration; ALS; Stress Granules; C9ORF72; TARDBP; Protein aggregates
Collection:: Biology and Medicine; Biotechnology; Theses and Dissertations

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Characterization of MuSK Transcripts and Proteins in Neural Stem Cells

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Description:: Population over the age of 65 is at a high risk of neurodegenerative diseases, especially Alzhiemer’s disease (AD), but there are currently no effective therapeutics …
Year:: 2024
Contributor:: Choi, Sei Hyun (creator); Fallon, Justin (Advisor); Huang, Yu-Wen Alvin (Reader); Freiman, Richard (Reader); Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:: theses
Subject:: Adult Neurogenesis; Neural stem cells; MuSK
Collection:: Biology and Medicine; Theses and Dissertations; Biotechnology

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Biotechnology

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Items (1-20) out of 151 results

Items (1-20) out of 151 results

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