Brown University
  1. Top
  2. ...
  3. Biomedical Engineering
  4. Theses and Dissertations

Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

Active filters

LanguageEnglish Cancel selected facet

Refine your results

  • 62 English

Items

Items (21-40) out of 62 results

Development of a Liquid Crystal Biosensor for the Detection of Endotoxin

Description:
This dissertation describes translational research conducted to develop a rapid diagnostic for the detection of endotoxin using liquid crystal sensor technology. Due to the elastic …
Year:
2009
Contributor:
McCamley, Maureen K. (creator)
Crawford, Gregory (director)
Artenstein, Andrew (director)
Artenstein, Andrew (reader)
Tripathi, Anubhav (reader)
Opal, Steven (reader)
Zumer, Slobodan (reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Liquid crystals
Endotoxins
Biomedical engineering
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Development of optical and electrochemical methods at the nano-scale for high-throughput biochemical sensing

Description:
Over the past few decades, remarkable progress has been made in the development of analytical biosensors for use in medical diagnostics. This dissertation focuses on …
Year:
2014
Contributor:
Siu, Vince Shing-Wing (creator)
Palmore, Tayhas (Director)
Pacifici, Domenico (Director)
Tripathi, Anubhav (Reader)
Wessel, Gary (Reader)
MacDonald, John (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Intein
Plasmonic Interferometry
Biosensors
Electrochemistry
Vitamin D
Glucose
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Electrochemical, biochemical, structural studies of cytochrome P450 monooxygenases involved in metabolism of vitamin D

Description:
This dissertation examines two cytochrome P450 monooxygenases, namely CYP27B1 and CYP24A1, for their potential applications in biosensors and drug metabolism, respectively. First, the feasibility of …
Year:
2011
Contributor:
Rhieu, Steve (creator)
Palmore, G. Tayhas (Director)
Reddy, G. Satyanarayana (Reader)
Pacifici, Domenico (Reader)
Brodsky, Alexander (Reader)
MacDonald, John (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Cytochrome P450
Electrode-driven catalysis
Vitamin D metabolism
Vitamin D
Bioelectrochemistry
Vitamin D--Metabolism
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Enhanced Efficacy of Nanotechnology-Driven Approaches against Antibiotic-Resistant Biofilms in the Presence of Metabolites

Description:
Antibiotic resistance and the lack of new antimicrobial therapies create significant challenges for the treatment of infections. Therefore, there is an urgent clinical need to …
Year:
2013
Contributor:
Durmus, Naside Gozde (creator)
Webster, Thomas (Director)
Webster, Thomas (Reader)
Tripathi, Anubhav (Reader)
Sun, Shouheng (Reader)
Morgan, Jeffrey (Reader)
Tripathi, Anubhav (Director)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
antibiotic resistance
antibacterial
metabolic simulation
superparamagnetic iron oxide nanoparticles (SPION)
nanorough surface
Nanotechnology
Antibacterial agents
Biofilms
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Fiber Optic Prosthesis

Description:
Future brain-computer interfaces will require technologies that enable efficient, reliable and high-speed transmission of broadband multichannel neural data out of the brain with minimal number …
Year:
2014
Contributor:
Park, Sunmee (creator)
Nurmikko, Arto (Director)
Jay, Gregory (Reader)
Ozden, Ilker (Reader)
Zia, Rashid (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
neural recording
MEA
extracellular recording
rat behavioral task
Fiber optics
Motor cortex
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Head Impact Exposure: The Biomechanics of Sports-Related Concussions

Description:
In our approach to understanding the biomechanics of concussions, we have defined head impact exposure as a multifactorial term that includes the frequency, magnitude, and …
Year:
2014
Contributor:
Wilcox, Bethany J. (creator)
Crisco, Joseph (Director)
Fleming, Braden (Reader)
Franck, Christian (Reader)
Raukar, Neha (Reader)
Greenwald, Richard (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
concussion
sport
gender
Brain--Concussion
Biomechanics
Sex
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Human Performance in Perceptual Tasks Involving Estimation and Navigation

Description:
This thesis is centered around a novel computer navigation experience. A computer game was developed to study how humans navigate from a start position to …
Year:
2012
Contributor:
Raiti, John G (creator)
Daniels, Jerry (Director)
Anderson, James (Reader)
Engbretson, Gustav (Reader)
Stein, John (Reader)
Zia, Rashid (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
estimation
Perception
Navigation
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Image-Based Analysis of Thumb Carpometacarpal Joint Biomechanics in Health and Early Osteoarthritis

Description:
Humans have a unique opposable thumb that maintains a fine balance between mobility and stability to allow motions that span from precision handling to power …
Year:
2015
Contributor:
Halilaj, Eni (creator)
Crisco, Joseph (Director)
Laidlaw, David (Director)
Sharon, Swartz (Reader)
Braden, Flemming (Reader)
Amy, Ladd (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
in vivo joint kinematics
computed tomography
shape analysis
orthopaedics
Ligaments
Cartilage
Tomography
Biomechanics
Orthopedics
Osteoarthritis
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

In Vitro Modeling of the Central Nervous System: Towards Optimized Cell-based Therapies

Description:
Cell-based therapy is a promising treatment option for central nervous system (CNS) disease and injury, but therapy strategies require optimization to achieve clinical improvement. The …
Year:
2015
Contributor:
Dingle, Yu-Ting Liu (creator)
Hoffman-Kim, Diane (Director)
Morgan, Jeffrey (Reader)
Darling, Eric (Reader)
Coulombe, Kareen (Reader)
Kaplan, David (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
mouse embryonic stem cells
in vitro differentiation
dopamine neurons
3D neural culture
neural spheroids
stem cell transplantation
Stem cells--Transplantation
Central nervous system
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Influence of microfabricated cues on the motility and growth of cells of the nervous system

Description:
This thesis investigates the response of nervous system cells to microfabricated environmental cues, with an emphasis on the development of quantitative methods and tools. We …
Year:
2013
Contributor:
Mitchel, Jennifer A (creator)
Hoffman-Kim, Diane (Director)
Morgan, Jeffrey (Reader)
Mende, Ulrike (Reader)
Franck, Christian (Reader)
Sakiyama-Elbert, Shelly (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
topography
micropattern
peripheral nervous system
guidance
Schwann cell
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Investigations of Complex Guidance Cues for Nerve Regeneration Using Novel In Vitro Platforms

Description:
Neurons have highly developed pathfinding abilities, but in any part of the nervous system, during development or after the challenge of injury, cues provided by …
Year:
2009
Contributor:
Kofron, Celinda M. (creator)
Hoffman-Kim, Diane (director)
Morgan, Jeffrey (reader)
Palmore, Tayhas (reader)
Webster, Thomas (reader)
Thompson, Deanna (reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Schwann cell
design of experiments
response surface methodology
axon guidance
Neurons
Astrocytes
Endothelial cells
Experimental design
Photolithography
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Kinetics, Mass Transport, and Adsorption in Diagnostic Microfluidic Devices

Description:
Microfluidic devices have the potential to transform diagnostic assays by reducing error, complexity, time, and cost. Furthermore, the miniaturization of multiple assay steps onto a …
Year:
2012
Contributor:
McCalla, Stephanie Ellen (creator)
Tripathi, Anubhav (Director)
Opal, Steven (Reader)
Rothstein, Jonathan (Reader)
Morgan, Jeffrey (Reader)
Palmore, Tayhas (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
NASBA
assay
transport
RNA amplification
Transcription
Microfluidics
Influenza
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Measuring Load in the Trapeziometacarpal Joint: Using Machine Learning to Improve in vivo Readings

Description:
The trapeziometacarpal (TMC) joint, responsible for much of the thumb’s mobility, is commonly affected by osteoarthritis (OA), especially in older female populations. This has extensive …
Year:
2022
Contributor:
Henke, Julia A. (creator)
Crisco, Joseph (thesis advisor)
Srivastava, Vikas (reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Machine learning
Trapezium (Anatomy)
Loads (Mechanics)
Biomechanics
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Membrane Conductance Through Voltage-Gated Ion Channels in the Presence of Carbon Nanomaterials and Dielectrophoretic Force

Description:
In order to explore the interactions of technological interfaces with the electrical properties of cells, two independent studies evaluate membrane conductivity in the presence of …
Year:
2011
Contributor:
Jakubek, Lorin Mari (creator)
Hurt, Robert (Director)
Lipscombe, Diane (Reader)
Palmore, G. Tayhas (Reader)
Tripathi, Anubhav (Reader)
Bellamkonda, Ravi (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Nanomaterials
Neuroengineering Nanotoxicology
Carbon nanotubes
Ion channels
Calcium
Dielectrophoresis
Nanostructured materials
Yttrium
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Methods and Analyzer for large data sets to quantify the effects of pre-exposure to opiate drugs on Infants through Cry Analysis

Description:
We worked to develop an analysis system that can process and classify large data sets of audio, specifically infant cries. This clinical project focuses on …
Year:
2019
Contributor:
Trejo-Sheu, Adriana (creator)
Silverman, Harvey (thesis advisor)
Bower, Allan (reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Neural networks (Computer science)
Machine learning
Infants
Pregnancy
Biomedical engineering
MATLAB
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Microfluidic Platforms for Molecular Diagnostics and Developmental Biology

Description:
Microfluidic technology provides a means of precisely controlling fluid flow for molecular analytics and diagnostics, as well for the biological analysis of cells and small …
Year:
2014
Contributor:
Angione, Stephanie L (creator)
Tripathi, Anubhav (Director)
Wessel, Gary (Reader)
Mermel, Leonard (Reader)
Morgan, Jeffrey (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
molecular diagnostics
influenza A
oocytes
Microfluidics
Molecular diagnosis
Developmental biology
Influenza A virus
Clostridium difficile
Embryos
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Microfluidics based Molecular Assays for Point-of-Care Diagnostics

Description:
Microfluidics based diagnostic systems are believed to have great competency for the ever-demanding healthcare in resource limited settings. These miniaturized devices have promise for detecting …
Year:
2014
Contributor:
Wang, Jingjing (creator)
Tripathi, Anubhav (Director)
Tang, Jay (Director)
Darling, Eric (Reader)
Palmore, G. Tayhas (Reader)
Opal, Steven (Reader)
Cohen, Seth (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
point-of-care
Microfluidics
Point-of-care testing
Biomolecules
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Microscale Transport Mechanisms: Effect of Electrokinetic and Interfacial Interactions

Description:
Electrokinetic transport, as a non-mechanical tool in driving the fluid is widely used in microfluidics. This mode of transport is highly desirable due to simple …
Year:
2013
Contributor:
Azadi, Glareh (creator)
Tripathi, Anubhav (Director)
Hurt, Robert (Reader)
Hoffman-Kim, Diane (Reader)
Wessel, Gary (Reader)
Maxey, Martin (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Electrokinetic flow
Protein-surfactant
Protein-based surfactants
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Models of Neurovascular Coupling in the Brain

Description:
We develop three new models of neurovascular coupling at each interface of the neurovascular unit. The neurovascular unit comprises neurons, microvessels, and astrocytes, a type …
Year:
2015
Contributor:
Witthoft, Alexandra Elisabeth (creator)
Karniadakis, George (Director)
Vlahovska, Petia (Reader)
Moore, Christopher (Reader)
Jones, Stephanie (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
neurovascular coupling
DPD
arteriole
Astrocytes
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Nano-fabrication and Characterization of Novel Titanium Surfaces for Vascular Stent Application

Description:
The limit of current vascular stents lies in in-stent restenosis due to incomplete endothelialization, vascular smooth muscle cell hyperproliferation and immune responses. In this case, …
Year:
2010
Contributor:
Lu, Jing (creator)
Webster, Thomas (Director)
Hurt, Robert (Reader)
Stein, Derek (Reader)
Franck, Christian (Reader)
Darling, Eric (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Vascular stents
Surface properties
Cell functions
Titanium
Nanotechnology
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Items (21-40) out of 62 results