Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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Items (1-20) out of 22 results

Accuracy of Measurement Systems for Quantifying In Vivo Wrist Kinematics

Description:: The wrist is a complex joint involved in the completion of functional tasks known as activities of daily living. The wrist is capable of six …
Year:: 2019
Contributor:: McHugh, Brian (creator); Crisco, Joseph (Advisor); Borton, David (Reader); Kofron, Celinda (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Wrist; Kinematics; Optical Motion Capture; Electrogoniometer; Biplanar Videoradiography
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Advancing Personalized Transcranial Direct Current Stimulation for Pediatric Neurology: Impact of Volume and Electrical Conductivity of Different Tissues under Different Target Strategies

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Description:: Background: High-definition transcranial direct current stimulation (HD-tDCS) is effective in the treatment of neurological disorders and cognitive enhancement. Yet, optimizing electric field distributions remains challenging …
Year:: 2025
Contributor:: Liu, Zeming (creator); Truccolo, Wilson (Advisor); Borton, David (Reader); Simeral, John (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Neuromodulation
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Advancing Tissue Engineered Neural Platforms to Explore Sex Differences in Ischemic Stroke and Traumatic Brain Injury

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Description:: Chapter 2: Of recent, the National Institutes of Health (NIH) has pushed for the inclusion of sex as a variable in basic science research and …
Year:: 2017
Contributor:: Zambuto, Samantha Grace (creator); Borton, David (Reader); Hoffman-Kim, Diane (Advisor); Madsen, Tracy (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: tissue engineering; Sex; traumatic brain injury; Neuroengineering; Cerebrovascular disease; women's health
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Biomarker Detection for Obsessive-Compulsive Disorder-related Distress

Description:: Obsessive compulsive disorder (OCD) is a neurological psychiatric disorder that is characterized by impulses and intrusive thoughts, known as “obsessions”, and repetitive behavior known as …
Year:: 2020
Contributor:: Puranik, Tanaya (creator); Borton, David (Advisor); Harrison, Matthew (Reader); McLaughlin, Nicole (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Obsessive-compulsive disorder; EEG biomarker
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Computational Modeling of Neural Cell-Type Targeting with Transcranial Magnetic Stimulation

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Description:: Objective: Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with established clinical applications, but heterogeneous treatment outcomes. An incomplete understanding of how stimulation …
Year:: 2026
Contributor:: Tajchman, Jacob (creator); Jones, Stephanie (Advisor); Moore, Christopher (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Magnetic brain stimulation; computational neural modeling
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Control of Perirhinal-dependent Novelty Exploration in Rats by Optogenetic Modulation of Prefrontal Cortex

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Description:: The perirhinal cortex (PER) has a well-established role in identification and recognition of objects. Our lab previously provided evidence that neuronal activity in PER may …
Year:: 2019
Contributor:: Ioannou, Alexia Evgenia (creator); Burwell, Rebecca (Advisor); Borton, David (Reader); Bath, Kevin (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Prefrontal cortex; Optogenetics
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Cortical Mapping of Nociception: An Electroencephalographic Approach

Description:: Chronic pain is a common medical condition across the globe, which impedes the daily lives of sufferers, and about which we have only a limited …
Year:: 2017
Contributor:: Levitt, Joshua (creator); Saab, Carl (Advisor); Borton, David (Reader); Roth, Julie (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Electroencephalography; pain; Nociceptive pain
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Delivering Functionalized Gold Nanorods to the Rodent Cerebral Cortex for Near-Infrared Neural Stimulation

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Description:: Introduction: Near-infrared neural stimulation has potential advantages such as non-invasiveness and no need for genetic manipulation. But it has not been well demonstrated in the …
Year:: 2020
Contributor:: Hussein, Kareem R. (creator); Lee, Jonghwan (Advisor); Borton, David (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: AuNRs; gold nanorods; intracortical injection; streptavidin; intracortical nanorod injection; NINS; near infrared neural stimulation; two-photon luminescence imaging; TPL imaging
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Detecting Biomarkers of OCD Through the Use of Behavioral Tasks: Pilot Data Analysis and Task Validation

Description:: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by unwanted thoughts (obsessions) and repetitive behaviors (compulsions) which significantly disrupt an individual’s daily life. Psychological distress …
Year:: 2022
Contributor:: Acuff, William Luke (creator); McLaughlin, Nicole (Advisor); Borton, David (Reader); Harrison, Matthew (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Neuropsychology; Obsessive-compulsive disorder; EEG biomarker; Neural Engineering
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Ensembles of Implantable Microdevices as a Multi-node Network for Neural Sensing and Stimulation

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Description:: This study focuses on the development of implantable biosensor microdevices for future brain-machine interfaces. Ensembles of spatially distributed sub-mm size devices, “neurograins, were designed to …
Year:: 2021
Contributor:: Lee, Jihun (creator); Nurmikko, Arto (Advisor); Larson, Lawrence (Reader); Truccolo, Wilson (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Wireless communication systems in medical care; Implantable neural interface
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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High and Low Compressive Loading on Tissue Engineered Cartilage

Description:: Introduction: Osteoarthritis is a debilitating joint disease that affects over 27 million Americans. Tissue engineered cartilage could be a viable option for patients that have …
Year:: 2017
Contributor:: Vasquez, Stephany (creator); Bilgen, Bahar (Advisor); Scott, Jeffrey (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: tissue engineering; Articular cartilage
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Intracortical Brain-Computer Interface Control of a Soft Robotic Glove: Insights on Sensory Feedback, Sustained Grasp Decoding, and the Restoration of Natural Hand Control for People with Tetraplegia

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Description:: Intracortical brain-computer interfaces (iBCIs) utilize signals recorded directly from the brain to allow individuals with paralysis to control assistive devices, such as computer cursors or …
Year:: 2025
Contributor:: Gusman, Jacob Tobias (creator); Hochberg, Leigh (Advisor); Borton, David (Reader); Bahar, R. Iris (Reader); Moore, Christopher (Reader); Putrino, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Motor cortex; Amyotrophic lateral sclerosis; Neuroengineering; Brain-computer interfaces; Proprioception; Neural decoding; Soft Robotics; human neuroscience; Mirror neurons
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Investigating Long-term, Progressive Cerebrovascular Alterations Using Optical Coherence Tomography in Alzheimer’s Disease

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Description:: Alzheimer's Disease (AD) is an irreversible neurodegenerative disorder with a decades long clinically asymptomatic phase which makes the early and accurate detection of the disease …
Year:: 2022
Contributor:: Lee, Jang-Hoon (creator); Lee, Jonghwan (Advisor); Borton, David (Reader); Plavicki, Jessica (Reader); Salloway, Stephen (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Alzheimer's disease; Optical coherence tomography; Brain--Blood-vessels
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Optical coherence tomography of cortical tissue in pilocarpine treated rats as a model for temporal lobe epilepsy

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Description:: Epilepsy affects over 3 million people in the United States alone. In many of those cases, the disease is refractory to medication, leaving patients limited …
Year:: 2018
Contributor:: Crowley, Shannon (creator); Lee, Jonghwan (Advisor); Asaad, Wael (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Optical coherence tomography; Pilocarpine; Epilepsy
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Optogenetics-based Neuromodulation of the Cortico-Basal-Ganglia Circuitry in a hemi-Parkinsonian Rat Model

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Description:: Deep brain stimulation (DBS) is an effective treatment for the mid/late stage Parkinson’s disease (PD), which significantly reduces the dopamine medication and improves motor symptoms. …
Year:: 2019
Contributor:: Yu, Zeyang (creator); Nurmikko, Arto (Advisor); Asaad, Wael (Reader); Borton, David (Reader); Hoffman-Kim, Diane (Reader); Ozden, Ilker (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Motor cortex; Optogenetics; Parkinson's disease; Deep Brain Stimulation; Globus pallidus externus; Subthalamic nucleus; 6-OHDA Rat Model; Beta oscillations
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Quantifying cortical tissue and vascular properties using optical coherence tomography

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Description:: Optical coherence tomography (OCT) is becoming increasingly popular for neuroscientific study, but it remains challenging to objectively quantify tissue and vascular properties from 3D or …
Year:: 2022
Contributor:: Stefan, Sabina (creator); Lee, Jonghwan (Advisor); Plavicki, Jessica (Reader); Borton, David (Reader); Moore, Christopher (Reader); Boas, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Cerebrovascular disease; Alzheimer's disease; Optical coherence tomography; Deep Learning
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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SEEG Signal Reconstruction and Prediction Using a CAE-LSTM Model

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Description:: Objective: The objective of this study is to develop a deep learning-based framework for reconstructing corrupted or missing SEEG (stereoelectroencephalography) signals, enabling improved analysis of …
Year:: 2025
Contributor:: Rangappa, Vibha Chaithanya (creator); Borton, David (Reader); Lee, Shane (Reader); Asaad, Wael (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomedical engineering; Computational neuroscience
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Shape Memory Nitinol Based Minimally Invasive Spinal Cord Stimulation Lead Concept for Pain Relief

Description:: Spinal Cord Stimulation (SCS) is a procedure that masks neuropathic pain for people with failed back surgery syndrome, postherpetic neuralgia and a host of other …
Year:: 2021
Contributor:: Sampath, Shailen Goel (creator); Telfeian, Albert (Reader); Borton, David (Reader); Srivastava, Vikas (Reader); Mathiowitz, Edith (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Chronic pain; Spinal Cord Stimulation; Shape memory alloys; nitinol; Spinal cord
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Simulation and Synthesis of Functional, Self-Assembling Amyloid Complexes for the Development of Antimicrobial Coatings

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Description:: Infections borne from the implantation of medical devices has continued to be a global health concern. Bacteria are capable of binding to the surfaces of …
Year:: 2020
Contributor:: Altemose, Quentin Donald (creator); Gray, Marissa (Reader); Borton, David (Reader); Shukla, Anita (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Molecular biology; Self-assembly; Peptides; antibacterial biomaterials; Bioengineering; Coatings; Ligand binding (Biochemistry); Peptides--Synthesis; amyloids; Bacteria--Adhesion; Peptides--Analysis
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Toward Assistive Communication Using a Discrete Mixed-Gesture Single-Hemisphere Intracortical Brain Computer Interface

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Description:: Intracortical brain computer interfaces (iBCIs) have the potential to improve assistive communication options for people with paralysis or other severe motor impairments. Current assistive communication …
Year:: 2024
Contributor:: Lütschg Espinosa, Stefan Eduardo (creator); Simeral, John (Advisor); Truccolo, Wilson (Reader); Borton, David (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Neural Interface System; Neuroengineering; Brain-computer interfaces; Assistive computer technology
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Biomedical Engineering Theses and Dissertations

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