Description
- Abstract:
- Epilepsy affects over 3 million people in the United States alone. In many of those cases, the disease is refractory to medication, leaving patients limited in their daily lives. When oral medication does not mitigate or relieve seizure activity, neurosurgery is performed in order to remove the seizure centers of the brain. Herein lies the unmet need in the treatment of this disease. This research is the first step toward creating a novel intraoperative microscope that can delineate the boundary between healthy and epileptogenic tissue in order to assist surgeons in the surgical resection of the diseased tissue in real time. This research aims to use Optical Coherence Tomography (OCT) to quantify the changes before and after seizure activity in cortical tissue. In a rodent model, seizures were induced using pilocarpine and verified by electrocorticography (ECoG). OCT was utilized to quantify the scattering coefficient, blood flow, and the structure of cortical tissue. The optical scattering coefficient of the cortical tissue exhibited a significant increase after the induced seizure activity. This distinct change in the optical property of tissue, which can be detected by OCT in real time and without fluorescence, supports the technical feasibility of the proposed intraoperative microscope.
- Notes:
- Thesis (Sc. M.)--Brown University, 2018
Access Conditions
- Rights
- In Copyright
- Restrictions on Use
- Collection is open for research.
Citation
Crowley, Shannon,
"Optical coherence tomography of cortical tissue in pilocarpine treated rats as a model for temporal lobe epilepsy"
(2018).
Biomedical Engineering Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/a1gg-a362
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Biomedical Engineering Theses and Dissertations
Theses and Dissertations for the Biomedical Engineering department....