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Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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Items (1-10) out of 10 results

Adipose-derived stem cell microtissues during mesenchymal condensation and chondrogenesis

Description:
Adipose-derived stems cells (ASCs) have key properties such as self-renew and differentiation that makes them a prime candidate to study various issues. An ASC spheroid …
Year:
2021
Contributor:
Gutierrez, Robert Alejandro (creator)
Morgan, Jeffrey (Reader)
Wong, Ian (Reader)
Mathiowitz, Edith (Reader)
Darling, Eric (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
adipose derived stem cells
Microtissues
3D Cell Culture
cellular forces
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

HCMP Characteristics Assessment for in situ Microenvironmental Force Measurement

Description:
Early tissue formation and regeneration is regulated by mechanical forces. However, few tools exist that can measure such forces in situ in cell-dense structures and …
Year:
2024
Contributor:
Rodriguez Navas, Marta (creator)
Darling, Eric (Advisor)
Morgan, Jeffrey (Reader)
Kesari, Haneesh (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
tissue engineering
mechanobiology
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Investigations in Cell Sorting Techniques

Description:
Sorting methods are important tools that enable cellular subpopulation isolation for basic science investigations and clinical therapies. Each method can be characterized by a set …
Year:
2019
Contributor:
Sutermaster, Bryan (creator)
Darling, Eric (Advisor)
Tripathi, Anubhav (Reader)
Fleming, Braden (Reader)
Shukla, Anita (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
tissue engineering
adipose derived stem cells
Regenerative medicine
Cell Sorting
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Labyrinthine Paths: The In Vivo Analysis of Hyper-Compliant Microcarriers

Description:
Intravenous (IV) drug delivery remains a cornerstone of systemic therapy; however, rapid biological clearance by the liver, spleen, kidneys, and circulating phagocytes significantly limits the …
Year:
2026
Contributor:
Roberts, Sharon Ashley (creator)
Darling, Eric (Advisor)
Mathiowitz, Edith (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Fluorescence
microparticles
drug delivery
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

LEVERAGING STEREOLITHOGRAPHY 3D-PRINTING CAPABILITIES FOR IN-HOUSE DEVICE FABRICATION

Description:
In order to execute more accurate in vitro studies on human tissues, the mechanical chemical conditions of cell activity must be replicated. This is accomplished …
Year:
2024
Contributor:
Weissberg, Tamsin (creator)
Darling, Eric (Advisor)
Morgan, Jeffrey (Reader)
Wong, Ian (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Three-dimensional printing
Stereolithography
Polydimethylsiloxane
Pressure vessels
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Mass-Added Density Modulation For Sorting Cells Based On Differential Surface Protein Levels

Description:
Cell sorting is a powerful tool in basic research and therapeutic enrichment. However, common cell sorting methods, such as fluorescence-activated cell sorting (FACS) and magnetic-activated …
Year:
2021
Contributor:
Sarnik, Sylvia Amalia (creator)
Shukla, Anita (Reader)
Morgan, Jeffrey (Reader)
Darling, Eric (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Flow cytometry
Cell Sorting
CD44
Centrifugation, Density gradient
Therapeutic Enrichment
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Molecular Recognition Tools for Live-Cell Labeling and Enrichment

Description:
Labeling live cells for gene and protein expression is critical to a myriad of research and clinical functions. These include diagnostic imaging, enrichment of heterogeneous …
Year:
2021
Contributor:
Dempsey, Megan (creator)
Darling, Eric (Advisor)
Dawson, Michelle (Reader)
Shukla, Anita (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Mesenchymal stem cells
Magnetic resonance imaging
Atomic force microscopy
Nuclear magnetic resonance spectroscopy
adipose derived stem cells
mechanophenotype
Regenerative medicine
Cell Sorting
live-cell labeling
cellular heterogeneity
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Quantifying Microenvironmental Forces in Engineered Tissue Models

Description:
Abstract of Microenvironmental Forces in Engineered Tissue Models, Prerna Chordiya, ScM, Brown University, May 2026 Microenvironmental mechanical forces are key regulators of cellular behavior, yet …
Year:
2026
Contributor:
Chordiya, Prerna (creator)
Kesari, Haneesh (Reader)
Dawson, Michelle (Reader)
Darling, Eric (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
engineered tissue
Microtissues
3D tissue engineering
cartilage engineering
musculokeletal tissues
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

The Role of Mechanical Properties in Stem Cell Adipogenesis

Description:
Abstract of “The Role of Mechanical Properties in Stem Cell Adipogenesis” by Nicholas R. Labriola, Ph.D., Brown University, May 2017 The mechanical properties of cells …
Year:
2016
Contributor:
Labriola, Nicholas Ryan (creator)
Darling, Eric (Advisor)
Chickering, Donald (Reader)
Morgan, Jeffrey (Reader)
Franck, Christian (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Stem cells--Research
Mesenchymal stem cells
molecular beacon
Cell differentiation
Polymers
Atomic force microscopy
Biomedical engineering
Biomechanics
Mimicry (Biology)
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Understanding Mechanophenotype Dependency on Cell Isolation Within Flow-Based Particle Analyzers

Description:
Mechanical properties of biological cells have been shown to correlate with their biomolecular state and function, and therefore methods to measure these properties at scale …
Year:
2023
Contributor:
Dubay, Ryan (creator)
Darling, Eric (Advisor)
Wong, Ian (Reader)
Srivastava, Vikas (Reader)
Dawson, Michelle (Reader)
Fiering, Jason (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Microfluidics
mechanophenotype
microparticles
Hydrogel
Cell separation
Calibration
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Items (1-10) out of 10 results