Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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Items (1-20) out of 31 results

A Non-Invasive Retinal Prosthesis Using Near-Infrared Photothermal Stimulation: From System Design to Cortical Signal Validation

Description:: In this study, a non-contact retinal prosthesis system based on gold nanorod (AuNR)-enhanced near-infrared photothermal stimulation was designed and verified. Based on previous research, the …
Year:: 2025
Contributor:: Li, Jinqian (creator); Lee, Jonghwan (Advisor); Srivastava, Vikas (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: retinal prosthetics; near infrared stimulation; gold nanorods
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A Preliminary Investigation of Damage in Marine Mammal Tissue due to Mechanical Loads using Silicone Rubber

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Description:: Underwater shock waves can cause harm to a variety of marine life. This problem can be detrimental to marine mammals that rely on echolocation. As …
Year:: 2025
Contributor:: simpson, tarik matthew (creator); Mathiowitz, Edith (Reader); Crisco, Joseph (Reader); Gray, Marissa (Reader); Srivastava, Vikas (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Materials--Mechanical properties; Marine melon; Marine mammalogy; Toothed whales
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A STUDY OF PRG4 AS IT RELATES TO URIC ACID AND GOUT

Description:: Abstract of A STUDY OF PRG4 AS IT RELATES TO URIC ACID AND GOUT, by Talia D’Ambruoso, ScM, Brown University, DECEMBER, 2021. Objective: Proteoglycan-4 (PRG4) …
Year:: 2021
Contributor:: D'Ambruoso, Talia (creator); Jay, Gregory (Reader); Gray, Marissa (Reader); Fleming, Braden (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Lubricin; Glycoproteins; Gout; Crystal growth
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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An Experimental Study of a Flexible, Self Healing Strain Sensor

Description:: Wearable health monitors represent an essential area of research in biomedical engineering, where strain sensors play a major role in enabling effective and continuous health …
Year:: 2024
Contributor:: Simon, Dashaun (creator); Gray, Marissa (Reader); Mathiowitz, Edith (Reader); Srivastava, Vikas (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomechanics; Solid Mechanics; Biomedical engineering--Research; Biosensors; Structural health monitoring
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Biomechanical Properties Maintained in 3D Microtissue Rings when Developing Ligament-Like Constructs

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Description:: Tendon and ligament injuries display poor healing capacities from the formation of scar-like tissue resulting in decreased mechanical properties. The application of biomechanics, the study …
Year:: 2024
Contributor:: Shaffer, Abigail (creator); Morgan, Jeffrey (Advisor); Horrigan, Diana (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomedical engineering; Biomechanics; tissue engineering; Fibroblasts; microtissue; Cell culture; Ligaments; 3D Cell Culture; in vitro; tensile testing; tensile properties; uterosacral ligament; Connective tissues
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Characterization of Alkaline-Accelerated Degradation of 3D-Printed Polylactic Acid Scaffolds

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Description:: Objective: Polylactic acid (PLA) has emerged as an attractive material for alloplastic craniofacial grafts owing to its established use in FDA-approved orthopedic medical devices, its …
Year:: 2026
Contributor:: Fang, Matthew (creator); Srivastava, Vikas (Advisor); Crisco, Joseph (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Accelerated degradation; 3D printing; Polylactic acid
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Clinical Considerations for a Minimally Invasive Wireless EEG System

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Description:: This thesis aims to contribute to the practical deployment of a new type of multichannel subdermal wireless EEG system under development at the Nurmikko Lab …
Year:: 2024
Contributor:: Chhabra, Akshit (creator); Nurmikko, Arto (Advisor); Berson, David (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Neuroengineering; Microfabrication; data science
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Deep Learning Based Retinal Vessel Segmentation in Optical Coherence Tomography Angiography Images

Description:: Alzheimer's Disease is one of the most devastating neurodegenerative conditions of our time, affecting millions of people worldwide and placing a burden on patients and …
Year:: 2026
Contributor:: Tamanekar, Siddhi Sunil (creator); Lee, Jonghwan (Advisor); Gray, Marissa (Reader); Raimondo, Theresa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Alzheimer's disease; Optical coherence tomography; Retina--Blood-vessels--Radiography
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Delivering Functionalized Gold Nanorods to the Rodent Cerebral Cortex for Near-Infrared Neural Stimulation

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Description:: Introduction: Near-infrared neural stimulation has potential advantages such as non-invasiveness and no need for genetic manipulation. But it has not been well demonstrated in the …
Year:: 2020
Contributor:: Hussein, Kareem R. (creator); Lee, Jonghwan (Advisor); Borton, David (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: AuNRs; gold nanorods; intracortical injection; streptavidin; intracortical nanorod injection; NINS; near infrared neural stimulation; two-photon luminescence imaging; TPL imaging
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Development and Optimization of an Intrinsic Optical Imaging System for Hemodynamic Correction of Fluorescent Signals

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Description:: Signals from fluorescent widefield calcium imaging of neural activity are susceptible to contamination and artifacts from vasculature in the brain. Hemoglobin is a strong absorber …
Year:: 2020
Contributor:: Cherian, Aaron Thomas (creator); Lee, Jonghwan (Advisor); Toussaint, Kimani (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Piezoelectric devices; Age-related macular degeneration; Neural prosthetics; GCaMP; Widefield imaging; Neurovascular Coupling; Neural stimulation; Intrinsic optical imaging
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Development and Validation of a Graph Theory Based Computational Analysis Tool for Investigating Neuronal Network Integrity in 3D Cortical Microtissue Models Under Vincristine Treatment and Ischemic and Ischemia-Reperfusion Conditions

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Description:: The thesis introduces a novel computational tool developed using graph theory and implemented in Wolfram Mathematica to analyze neuronal network integrity within three-dimensional cortical microtissues. …
Year:: 2024
Contributor:: Burgess, Amina Zohor (creator); Hoffman-Kim, Diane (Advisor); Gray, Marissa (Reader); González-Cruz, Rafael (Reader); Kesari, Haneesh (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: tissue engineering; Algorithms; engineered tissue; computational analysis; Graph theory; Toxicity testing--In vitro; 3D Cell Culture; Neuroscience; Hypoxic-ischemic brain injury; Image analysis--Data processing; Vincristine
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Development of Method for A-Scan Ultrasound Localization of Solid, Nonpalpable Breast Lesions

Description:: Breast cancer is one of the most prevalent forms of cancer in the U.S. and incidence rates continue to rise. With increased access to routine …
Year:: 2025
Contributor:: Rowey, Rachel (creator); Srivastava, Vikas (Advisor); Gray, Marissa (Reader); Crisco, Joseph (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Breast--Ultrasonic imaging
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Development of Method for A-Scan Ultrasound Localization of Solid, Nonpalpable Breast Lesions

Description:: Breast cancer is one of the most prevalent forms of cancer in the U.S. and incidence rates continue to rise. With increased access to routine …
Year:: 2025
Contributor:: Palac, Karolina (creator); Gray, Marissa (Reader); Crisco, Joseph (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Breast--Ultrasonic imaging
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Effective Gold Nanoparticle Delivery to the Retina for Plasmonic Retinal Prosthetics

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Description:: Abstract of (Effective Gold Nanoparticle Delivery to the Retina for Plasmonic Retinal Prosthetics), by (Hafithe Mohammed AlGhosain), Degree [ScM.], Brown University, May (2019). Retinitis pigmentosa …
Year:: 2019
Contributor:: AlGhosain, Hafithe M (creator); Dawson, Michelle (Reader); Gray, Marissa (Reader); Lee, Jonghwan (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Retinal ganglion cells; AuNRs; Retinitis pigmentosa; Retinitis pigmentosa--Research; neural sitmulation; retinal prosthetics; Thy 1.2; near infrared neuronal stimulation; Inner limiting membrane; sub-ILM injection; retinal delivery; nanoinjector; plasmonic retinal prosthetic; retinal stimulation
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Hallmark Mutation Effects on Epithelial Ovarian Cancer Phenotype and Tumor Microenvironment Interactions

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Description:: Ovarian cancer is a rare but deadly disease. Patients are often diagnosed at late-stage, metastatic conditions, resulting in a poor survival rate. High-grade serous carcinoma …
Year:: 2024
Contributor:: Quinones, Jacqueline (creator); Dawson, Michelle (Advisor); Wong, Ian (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Paclitaxel; tp53; Polyploidal giant cancer cells; epithelial ovarian cancer; Tumor Microenvironment; BRCA genes; Cisplatin
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Inducing Mesophase Morphologies In Isotactic Polypropylene

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Description:: This paper investigates the impact of processing conditions, specifically temperature and pressure, on inducing mesophase morphologies in Isotactic Polypropylene (iPP). iPP is a highly valued …
Year:: 2024
Contributor:: Sundaresan, Gayathri (creator); Mathiowitz, Edith (Advisor); Shukla, Anita (Reader); Coulombe, Kareen (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Polymers; Polymer chemistry
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Innovations for Resource-Constrained Settings: Opioid Crisis and Wound Care

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Description:: Resource-constrained settings can be defined as areas facing severe inequities, areas with limited access to basic necessities, and low to middle-income countries. Addressing clinical needs …
Year:: 2022
Contributor:: Choi, Eunsung (creator); Kofron, Celinda (Advisor); Gray, Marissa (Reader); Fraser, Hamish (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Medical instruments and apparatus; resource-limited settings; negative pressure wound therapy
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Innovations for Resource-Constrained Settings: Opioid Crisis and Wound Care

Description:: Resource-constrained settings can be defined as areas facing severe inequities, areas with limited access to basic necessities, and low to middle-income countries. Addressing clinical needs …
Year:: 2022
Contributor:: Dhar, Yosman (creator); Gray, Marissa (Reader); Kofron, Celinda (Advisor); Fraser, Hamish (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Innovation; Engineering design
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Insights into Pressure-Temperature Induced Morphology and Mesophase Formation in the Non-Mesogenic Polymer Polyethylene Oxide

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Description:: This work aimed to identify the morphological effects of heat and pressure on high molecular weight (300,000 kDa) polyethylene oxide, with a specific focus on …
Year:: 2021
Contributor:: Clevinger, Tobias B (creator); Mathiowitz, Edith (Advisor); Srivastava, Vikas (Reader); Gray, Marissa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Polymers; Biomedical engineering; Biomedical materials; Polyethylene oxide
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Investigating the Role of Endothelial Connexin-43 in Alzheimer’s Disease: An End to End Framework for Immunofluorescence Visualization and Quantitative Image Analysis

Description:: Objective: Despite extensive evidence of APOE4-driven vascular dysfunction, cerebral endothelial connexins that play a critical role in endothelial communication and vasodilation remain poorly characterized in …
Year:: 2025
Contributor:: Harilal, Nayana (creator); Gray, Marissa (Reader); Lee, Jonghwan (Advisor); Morgan, Jeffrey (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Image analysis; Alzheimer's disease; Endothelial cells; Gap junctions (Cell biology); Hippocampus (Brain)--Research; Immunofluorescence--Methodology; Connexin 43; Vascular Dysfunction
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Biomedical Engineering Theses and Dissertations

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