Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

Theses and Dissertations for the Molecular Pharmacology, Physiology, and Biotechnology department.

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Items (1-20) out of 178 results

3D Culture of HepG2 Liver Cancer Cells in Transglutaminase-Crosslinked Gelatin Scaffolds

Description:: Objective: The objective of this thesis was to establish an experimental 3D culture system based on liver cancer (HepG2) cells in a gelatin scaffold and …
Year:: 2021
Contributor:: Avila, Mary Flordelys Dizon (creator); Ip, Blanche (Reader); Schell, Jacquelyn (Reader); Wong, Ian (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: 3D Cell Culture
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Data-Driven Approach for Characterizing Childhood and Adult Malnutrition at the National and Global Level

Description:: This thesis explores clinical and social factors to characterize underweight malnutrition on the national and global level using the UNICEF Childhood Malnutrition Datasets (survey-level data …
Year:: 2020
Contributor:: DeBare, Mariana L (creator); Schell, Jacquelyn (Reader); Chen, Elizabeth (Advisor); Gillani, Fizza (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Malnutrition in children; Malnutrition--Prevention; Malnutrition--Social aspects; Malnutrition; Malnutrition in the elderly; Malnutrition in the United States
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Matter of Life and Death: Novel Ligands Mediating Cytotoxic Function and Revealing Metabolically Stimulative Function of the Sigma-2 Receptor in Human Cancer

Description:: The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Year:: 2016
Contributor:: Nicholson, Hilary E (creator); Bowen, Wayne (Director); Marshall, John (Reader); Matsumoto, Rae (Reader); Oancea, Elena (Reader); Zhitkovich, Anatoly (Reader); Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:: theses
Subject:: sigma-2 receptor; CM572; CM764; sigma receptor; cellular metabolism; triple negative breast cancer; Glycolysis; Neuroblastoma
Language:: English
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A multi-host approach to evaluate antibiotic compounds against methicillin-resistant Staphylococcus aureus

Description:: Antibiotic resistance is an urgent threat to public health. For this reason, new antimicrobial therapies are constantly needed to treat ever-evolving pathogens. One such pathogen …
Year:: 2021
Contributor:: White, Alexis (creator); Mylonakis, Eleftherios (Advisor); Belenky, Peter (Reader); Scott, Jeffrey (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Greater wax moth; Caenorhabditis elegans; MRSA
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Novel Role for Programmed Cell Death Receptor Ligand 2 (PD-L2) in Sepsis-Induced Hepatic Dysfunction

Description:: Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
Year:: 2017
Contributor:: Le, Marilyn C (creator); Zimmerman, Anita (Reader); Bowen, Wayne (Reader); Ayala, Alfred (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Immunology; Septicemia
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A novel target for insulin resistance in Nonalcoholic Steatohepatitis

Description:: NAFLD and NASH have caught the attention of scientists to make an accurate diagnosis and find effective treatments. Studies have found that both hyperinsulinemia and …
Year:: 2019
Contributor:: Lin, Mengqi (creator); Wands, Jack (Advisor); Li, Jisu (Reader); Zhang, Songhua (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Liver--Diseases
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Novel, Context Dependent Two Alternative Forced Choice Task for the Exploration of the Neural Correlates of Higher Order Cognition in Mice

Description:: The brain’s ability to attribute valence to sensory stimuli in our environment and modulate these associations to reflect its current state is essential for goal …
Year:: 2017
Contributor:: Gill, Jay Lathen (creator); Moore, Christopher (Advisor); Frank, Michael (Reader); Bath, Kevin (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: behavioral neuroscience
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Accelerating Chemical Synthesis via High-throughput Technologies and Automated Platforms and its Application to Drug Discovery and Molecular Informatics

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Description:: Automation has been rapidly changing the research performed in the scientific community. With more high-throughput technologies available to both academic and industrial scientists, improvements to …
Year:: 2020
Contributor:: Dombroski, Amanda (creator); Sello, Jason (Advisor); Bowen, Wayne (Reader); Creton, Robbert (Reader); Basu, Amit (Reader); Peterson, Randall (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Zebrafish Behavior; GABA-A receptor; Molecular Memory; Automation; Anesthetics; Chemical Library Synthesis; Chemical Computation; Neuropharmacology; High-Throughput Behavioral Analysis; Molecular Informatics; Polypharmacology; Sedatives; Stimulants; Sedation Reversal Agents
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Activating a Cancer-Specific Apoptotic Switch: Preclinical Evaluation of a Novel Combination of ONC201/ONC212 and TRAIL

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Description:: ONC201 is a novel, orally bioavailable small molecule that is the founding member of the imipridone class and is currently in clinical trials for various …
Year:: 2020
Contributor:: Jhaveri, Aakash Viren (creator); El-Deiry, Wafik (Advisor); Bartnikas, Thomas (Reader); Sanders, Jennifer (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: cancer therapeutics
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Activation of Ano1 is Associated with Apoptosis of Pulmonary Endothelial Cells: Implications for Pulmonary Arterial Hypertension

Description:: Aberrant endothelial cell (EC) proliferation plays an important role in the vascular remodeling observed in Pulmonary Arterial Hypertension (PAH). Anoctamin-1 (Ano1), a calcium activated chloride …
Year:: 2016
Contributor:: Allawzi, Ayed M (creator); Choudhary, Gaurav (Director); Zimmerman, Anita (Reader); Rounds, Sharon (Reader); Harrington, Elizabeth (Reader); Sham, James (Reader); Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:: theses
Subject:: Endothelial; pulmonary arterial hypertension; PH; PAH; Anoctamin-1; Ano1; TMEM16A; Endothelial cells; Endothelium; Pulmonary hypertension
Language:: English
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Active Targeting Antifungal Drug Delivery Systems: A Trends Report, Market Analysis, and Roadmap to Commercialization

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Description:: In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Year:: 2022
Contributor:: Whitely, Cutler B (creator); Mathiowitz, Edith (Reader); Schell, Jacquelyn (Reader); Shukla, Anita (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Biotechnology; Nanoparticles; Drug delivery systems; Pharmaceutical industry; United States. Food and Drug Administration
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Advancing an in vivo-relevant three-dimensional neural spheroid model for CNS disease modeling

Description:: Central nervous system disease pathologies are poorly understood in part due to the inability of animal and in vitro models to recapitulate their complexity. It …
Year:: 2017
Contributor:: Kramer, Liana (creator); Hoffman-Kim, Diane (Advisor); Schell, Jacquelyn (Reader); Mende, Ulrike (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: tissue engineering; in-vitro; Cerebral ischemia; Neurovascular diseases
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Advancing in vitro models of neuroinflammation: Toward understanding and mitigating innate immune responses

Description:: Advancements in neurotechnology have helped people living with paralysis regain function through brain control of communication interfaces, prostheses, and even restored command of one’s own …
Year:: 2021
Contributor:: Atherton, Elaina Hope (creator); Borton, David (Advisor); Colvin, Vicki (Reader); Hoffman-Kim, Diane (Reader); Shukla, Anita (Reader); Capadona, Jeffrey (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: three-dimensional culture; Drug delivery systems; calcium imaging; Implantable neural interface; Graph theory; Layer-by-layer; Functional Connectivity; Cerium oxides; Endotoxins; Foreign-body reaction; Neuroimmunology; Oxidative stress
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Age-Associated Arrhythmogenic Substrate and Trigger in a Rabbit Model of Cardiac Aging

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Description:: Aging is associated with an increased risk of arrhythmias and sudden cardiac death (SCD). Yet, much remains unknown about the mechanisms that underlie the age-related, …
Year:: 2013
Contributor:: Cooper, Leroy Leon (creator); Koren, g (Director); Koren, Gideon (Director); Mende, Ulrike (Reader); Harrington, Elizabeth (Reader); Sedivy, John (Reader); Lakatta, Edward (Reader); Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:: theses
Subject:: senescence; calcium dynamics; ryanodine receptor; Heart; Arrhythmia; Aging; Calcium; Ryanodine--Receptors
Language:: English
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Alpha-Bungarotoxin as a tool for exploring naturally insensitive ion channels

Description:: In this thesis,alpha-bungarotoxin (Bgtx) was validated as a tool for exploring the function and regulation of three otherwise Bgtx-insensitive ion channels: the first is a …
Year:: 2009
Contributor:: Liu, Jing (creator); Hawrot, Edward (director); Zimmerman, Anita (reader); Kauer, Julie (reader); Bowen, Wayne (reader); Jacob, Michele (reader); Brown University. Division of Biology and Medicine. Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:: theses
Subject:: alpha-bungarotoxin; nicotinic receptor; voltage gated potassium channel; GABA type A receptor; Ion channels
Language:: English
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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An Analysis of Online Discussions about Neurosurgery for Obsessive-Compulsive Disorder

Description:: Background: For some patients with severe, treatment-resistant obsessive-compulsive disorder (OCD), neurosurgical interventions may be considered. While a few studies have assessed both patient and provider …
Year:: 2021
Contributor:: Hornstein, Samuel (creator); Rosen, Rochelle (Reader); Greenberg, Benjamin (Reader); McLaughlin, Nicole (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Biotechnology; Obsessive-compulsive disorder; Neurosciences--Research; Medicine--Research; Online Health; Nervous system--Surgery
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Analysis of Antimicrobial Bacteriophage-Hydrogel Therapies

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Description:: n/a
Year:: 2022
Contributor:: Kurapati, Sai (creator); Schell, Jacquelyn (Reader); Analoui, Mostafa (Reader); Shukla, Anita (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Biotechnology
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Analysis of Polystyrene Microsphere Uptake in Passively Fed Danio rerio Larvae via FT-IR Spectroscopy and Fluorescence-Based Detection

Description:: Microplastic pollution of marine environments is a pressing problem for the health of aquatic ecosystems and for global food supply. Many studies have been done …
Year:: 2021
Contributor:: Maxwell, Tyler (creator); Mathiowitz, Edith (Advisor); Creton, Robbert (Reader); Jong, Yong (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Fluorescence microscopy; Zebra danio; Polymeric nanoparticles; FT-IR; Microplastics; Plastic pollution
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Analyzing & Determining the Structure of Penicillin Binding Protein 5 from Enterococcus faecium

Description:: Penicillin Binding Protein 5 (PBP5) is a membrane bound transpeptidase that plays an important role in β-lactam antibiotic resistance in Enterococcus faecium. Normally, β-lactams inhibit …
Year:: 2017
Contributor:: Lee, Christopher (creator); Peti, Wolfgang (Advisor); Schell, Jacquelyn (Reader); Mathiowitz, Edith (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: PBPs; Crystallography; High performance liquid chromatography
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Antagonistic effect of aspartate-β-hydroxylase on chemotherapeutics in cholangiocarcinoma

Description:: Bile duct cancer, known as cholangiocarcinoma (CCA), is a rare but highly aggressive cancer with a 3% incident in all gastrointestinal cancers. The only known …
Year:: 2019
Contributor:: Cao, Kevin (creator); Wands, Jack (Advisor); Huang, Chiung-Kuei (Reader); Li, Ji Su (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: DNA damage; Bile ducts--Cancer; ASPH
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

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Items (1-20) out of 178 results

Items (1-20) out of 178 results

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