The central nervous system (CNS) contains a complex assortment of cell types and extracellular matrix proteins, which are arranged into an intricate architecture and ultimately …
Adipose-derived stem cells (ASCs) represent a promising cell source for cell-based therapies and tissue engineering applications because of their multipotency and abundance. However, these cells …
Characterizing the morphology of the carpometacarpal (CMC) joint and how it changes with osteoarthritis progression is important for understanding the pathoetiology of this multifactorial disease. …
Unlike birds and insects, bats fly using compliant and slender membrane wings. Membrane wings offer negligible bending stiffness, and thus when they experience aerodynamic load, …
In our approach to understanding the biomechanics of concussions, we have defined head impact exposure as a multifactorial term that includes the frequency, magnitude, and …
This thesis investigates the response of nervous system cells to microfabricated environmental cues, with an emphasis on the development of quantitative methods and tools. We …
Neutrophils are the most abundant circulating white blood cell in the human body and the first responders to tissue injury and infection. While inflammation has …
The limit of current vascular stents lies in in-stent restenosis due to incomplete endothelialization, vascular smooth muscle cell hyperproliferation and immune responses. In this case, …
Creating the safest possible playing environment for football athletes has been at the forefront of researchers and governing bodies alike. While most of the research …
The work in this thesis demonstrates that mesenchymal stem cell (MSC) function is influenced by aging and chemotherapy. Furthermore, these results illustrate that inherent differences …
There exists a time frame after mild Traumatic Brain Injuries (mTBI) in which pathophysiological changes still remain within the brain during which a second injury …
Abstract of “The Role of Mechanical Properties in Stem Cell Adipogenesis” by Nicholas R. Labriola, Ph.D., Brown University, May 2017 The mechanical properties of cells …
The research presented in this thesis aims to advance our understanding of cellular behavior in physiologically relevant environments composed of single cues or multiple cues. …