Objective: The objective of this thesis was to establish an experimental 3D culture system based on liver cancer (HepG2) cells in a gelatin scaffold and …
This thesis explores clinical and social factors to characterize underweight malnutrition on the national and global level using the UNICEF Childhood Malnutrition Datasets (survey-level data …
The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Antibiotic resistance is an urgent threat to public health. For this reason, new antimicrobial therapies are constantly needed to treat ever-evolving pathogens. One such pathogen …
Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
NAFLD and NASH have caught the attention of scientists to make an accurate diagnosis and find effective treatments. Studies have found that both hyperinsulinemia and …
The brain’s ability to attribute valence to sensory stimuli in our environment and modulate these associations to reflect its current state is essential for goal …
Automation has been rapidly changing the research performed in the scientific community. With more high-throughput technologies available to both academic and industrial scientists, improvements to …
ONC201 is a novel, orally bioavailable small molecule that is the founding member of the imipridone class and is currently in clinical trials for various …
Aberrant endothelial cell (EC) proliferation plays an important role in the vascular remodeling observed in Pulmonary Arterial Hypertension (PAH). Anoctamin-1 (Ano1), a calcium activated chloride …
In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Central nervous system disease pathologies are poorly understood in part due to the inability of animal and in vitro models to recapitulate their complexity. It …
Advancements in neurotechnology have helped people living with paralysis regain function through brain control of communication interfaces, prostheses, and even restored command of one’s own …
Aging is associated with an increased risk of arrhythmias and sudden cardiac death (SCD). Yet, much remains unknown about the mechanisms that underlie the age-related, …
In this thesis,alpha-bungarotoxin (Bgtx) was validated as a tool for exploring the function and regulation of three otherwise Bgtx-insensitive ion channels: the first is a …
Background: For some patients with severe, treatment-resistant obsessive-compulsive disorder (OCD), neurosurgical interventions may be considered. While a few studies have assessed both patient and provider …
Microplastic pollution of marine environments is a pressing problem for the health of aquatic ecosystems and for global food supply. Many studies have been done …
Penicillin Binding Protein 5 (PBP5) is a membrane bound transpeptidase that plays an important role in β-lactam antibiotic resistance in Enterococcus faecium. Normally, β-lactams inhibit …
Bile duct cancer, known as cholangiocarcinoma (CCA), is a rare but highly aggressive cancer with a 3% incident in all gastrointestinal cancers. The only known …
