SHP-1 is a protein found in leukocytes and epithelial cells that regulates inflammatory responses. In inflammatory, destructive and fibrotic conditions such as in pulmonary fibrosis, SHP-1 is found in notably lower levels. Epigenetic regulation of SHP-1 could occur through methylation of cytosine residues in the promoter regions. This suppression of SHP-1 would likely exacerbate tissue damage due to inflammation. This project examines the DNA methylation status of the SHP-1 promoter 2 region under normal and fibrotic conditions, both in human samples and murine models. We hypothesize that DNA methylation of the SHP-1 promoter region occurs more frequently under fibrotic conditions. Epigenetic regulation of SHP- 1 may have a hand in the severity of inflammatory conditions such as idiopathic pulmonary fibrosis, or IPF. This project aims to establish SHP-1 as a biomarker, applicable in diagnosis or prognosis of IPF using plasma samples.
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Citation
Palisoc, Tessa L.,
"Epigenetic Regulation of SHP-1 Expression in Pulmonary Fibrosis"
(2020).
Pathobiology Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/aqe2-bw06
