Description
- Abstract:
- Generation of forces is essential for the migration of neutrophils to the sites of infection or injury. The mechanical properties and local confinement of the surrounding microenvironment play a significant role in regulating these forces. However, it is challenging to decouple each of these features experimentally without inherently changing the microstructure of the cell environment. Presented here is an experimental method that is used to isolate confinement and substrate stiffness as single variables in the neutrophil environment. Using a combination of fast iterative digital volume correlation and traction force microscopy techniques, this dissertation demonstrates that neutrophils induce finite displacements on their surroundings. Furthermore, the findings show that neutrophil-generated forces are highly affected by confinement and stiffness of their microenvironment.
- Notes:
- Thesis (Ph.D. -- Brown University (2015)
Access Conditions
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- In Copyright
- Restrictions on Use
- Collection is open for research.
Citation
Toyjanova, Jennet,
"The Effect of Confinement on Neutrophil Force Generation"
(2015).
Mechanics of Solids Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://doi.org/10.7301/Z0TM78GZ
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Mechanics of Solids Theses and Dissertations
Theses and Dissertations for the Mechanics of Solids department....