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Stem-loop binding proteins (SLBP) regulates the expression of the HIV-1 restriction factor APOBEC3G

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Overview

Year:
2016
Contributor:
Cheruiyot, Collins (author)
Li, Ming (advisor)
Gidas, Basilis (reader)
Genre:
theses
Subject:
HIV infections
Apolipoprotein B
SLPB
Extent:
21 p.
DOI
https://doi.org/10.7301/Z0F47MJR

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Description

Abstract:
Lymphocytes possess innate mechanisms for regulating the HIV-1 viral cycle. Using proteomics and functional analysis, we recently identified Stem-Loop Binding Protein (SLBP) as a histone related HIV-1 host factor that restricts integration and transcription of HIV-1. Our findings also demonstrated that SLBP depletion leads to a decrease in the HIV-1 restriction factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G) in lymphocytic cells at both the RNA and protein levels. In this study, we use various techniques to further investigate the molecular mechanism for the novel relationship between SLBP and APOBEC3G.
Notes:
Concentration: Applied Mathematics/Biology (ScB)

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Citation

Cheruiyot, Collins, "Stem-loop binding proteins (SLBP) regulates the expression of the HIV-1 restriction factor APOBEC3G" (2016). Biology and Medicine Theses and Dissertations, Applied Mathematics Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z0F47MJR

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