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A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations.

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Contributor:
Kabadi, Pranita K. (creator)
Rodd, April L. (creator)
Simmons, Alysha E. (creator)
Messier, Norma J. (creator)
Hurt, Robert H. (creator)
Kane, Agnes B. (creator)
Subject:
Three-dimensional imaging
Nanoparticles
Toxicology
Carbon nanotubes
DOI
https://doi.org/10.1186/s12989-019-0298-0

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Description

Abstract:
Kabadi et al. Particle and Fibre Toxicology (2019) 16:15 https://doi.org/10.1186/s12989-019-0298-0. Multi-walled carbon nanotubes (MWCNT) have been shown to elicit the release of inflammatory and pro-fibrotic mediators, as well as histopathological changes in lungs of exposed animals. Current standards for testing MWCNTs and other nanoparticles (NPs) rely on low-throughput in vivo studies to assess acute and chronic toxicity and potential hazard to humans. Several alternative testing approaches utilizing two-dimensional (2D) in vitro assays to screen engineered NPs have reported conflicting results between in vitro and in vivo assays. Compared to conventional 2D in vitro or in vivo animal model systems, three-dimensional (3D) in vitro platforms have been shown to more closely recapitulate human physiology, providing a relevant, more efficient strategy for evaluating acute toxicity and chronic outcomes in a tiered nanomaterial toxicity testing paradigm.
Notes:
This research is supported by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42ES013660, NIEHS Training Grant T32 ES007272, NIEHS Bioengineering Research Partnership Grant U01 ES028184, and Unilever, and a generous gift from Donna McGraw Weiss ‘89 and Jason Weiss.

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Use and Reproduction
Attribution 4.0 International (CC BY 4.0)

Citation

Kabadi, Pranita K., Rodd, April L., Simmons, Alysha E., et al., "A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations." Brown Superfund Project 2: Adverse Human Health Impacts of Nanomaterials Digital Archive, Kane Lab Publications, Brown Superfund Project 4: Nanomaterial Design for Environmental Health and Safety, Brown Superfund Presentations & Publications. Brown Digital Repository. Brown University Library. https://doi.org/10.1186/s12989-019-0298-0

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