Description
- Abstract:
- Kabadi et al. Particle and Fibre Toxicology (2019) 16:15 https://doi.org/10.1186/s12989-019-0298-0. Multi-walled carbon nanotubes (MWCNT) have been shown to elicit the release of inflammatory and pro-fibrotic mediators, as well as histopathological changes in lungs of exposed animals. Current standards for testing MWCNTs and other nanoparticles (NPs) rely on low-throughput in vivo studies to assess acute and chronic toxicity and potential hazard to humans. Several alternative testing approaches utilizing two-dimensional (2D) in vitro assays to screen engineered NPs have reported conflicting results between in vitro and in vivo assays. Compared to conventional 2D in vitro or in vivo animal model systems, three-dimensional (3D) in vitro platforms have been shown to more closely recapitulate human physiology, providing a relevant, more efficient strategy for evaluating acute toxicity and chronic outcomes in a tiered nanomaterial toxicity testing paradigm.
- Notes:
- This research is supported by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42ES013660, NIEHS Training Grant T32 ES007272, NIEHS Bioengineering Research Partnership Grant U01 ES028184, and Unilever, and a generous gift from Donna McGraw Weiss ‘89 and Jason Weiss.
Access Conditions
- Use and Reproduction
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- Attribution 4.0 International (CC BY 4.0)
Citation
Kabadi, Pranita K., Rodd, April L., Simmons, Alysha E., et al.,
"A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations."
Brown Superfund Project 2: Adverse Human Health Impacts of Nanomaterials Digital Archive, Kane Lab Publications, Brown Superfund Project 4: Nanomaterial Design for Environmental Health and Safety, Brown Superfund Presentations & Publications.
Brown Digital Repository. Brown University Library.
https://doi.org/10.1186/s12989-019-0298-0
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Brown Superfund Project 2: Adverse Human Health Impacts of Nanomaterials Digital Archive
This archive is for the long-term preservation and public dissemination of data and digital research products collected and created by researchers associated with Brown University Superfund Research Program Project 2: "Adverse Human Health Impacts of Nanomaterials". Project Leader: Agnes B. …... -
Kane Lab Publications
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Brown Superfund Project 4: Nanomaterial Design for Environmental Health and Safety
This archive is for the long-term preservation and public dissemination of data and digital research products collected and created by researchers associated with Brown University Superfund Research Program Project 3: "Nanomaterial Design for Environmental Health and Safety". Project Leader: Robert …... -
Brown Superfund Presentations & Publications
This collection contains research articles, conference papers, research posters, and slide presentations associated with Brown University Superfund Research Program's investigators and research projects....