Injectable and Self-assembled Nano-Matrix for Stem Cell Homing

Yau, Anne

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Year:: 2019
Contributor:: Yau, Anne (creator); Schell, Jacquelyn (Reader); Scott, Jeffrey (Reader); Chen, Yupeng (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Fractures; Biomedical materials; nanomaterials; Janus-based Nanotubes; Low bone density
Extent:: 9, 42 p.
DOI: https://doi.org/10.26300/xedj-6237

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Description

Abstract:: About 6 million people suffer fractures each year in North America, and 5 to 10 percent of those cases involve patients who either have delayed healing or fractures that do not heal. MSCs can differentiate into bone-forming osteoblasts to aid in fracture healing. To guide MSCs homing into the fracture site, we developed a Nano-Matrix which can be injected into the target location, then self-assemble into a cell growth scaffold. The Nano-Matrix is formed by Janus base nanotubes (JBNTs) and Fibronectin (FN). JBNTs are nucleobase-derived nanotubes mimicking collagen fibers, and FN is one of the cell adhesive glycoproteins, is responsible for cell-extracellular matrix interaction by guiding the stem cells to migrate or to differentiate to desired cells types. Here, we will show the successful fabrication and characterization of the Nano-Matrix as well as their excellent bioactivity in encouraging human mesenchymal cells (hMSCs) adhesion and migration. This work lays a solid foundation for using the Nano-Matrix as an injectable approach to improve hMSCs homing and function for bone fracture healing.
Notes:: Thesis (Sc. M.)--Brown University, 2019

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Rights: In Copyright
Restrictions on Use: Collection is open for research.

Citation

Yau, Anne, "Injectable and Self-assembled Nano-Matrix for Stem Cell Homing" (2019). Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/xedj-6237

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Molecular Pharmacology, Physiology, and Biotechnology Theses and Dissertations

Theses and Dissertations for the Molecular Pharmacology, Physiology, and Biotechnology department.
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