Description
- Abstract:
- Adult spinal deformity (ASD) is a chronic musculoskeletal condition characterized by abnormal spinal curvature and adverse psychological well-being. However, the mental health burden of ASD remains poorly characterized. This retrospective cross-sectional cohort study compared the prevalence and odds of mental health conditions in the ASD population to a matched general population cohort using the nationally representative All of Us Research Program. ASD patients (n = 6,531) were identified using ICD-9/10. Using 1:1 nearest neighbor propensity matching without replacement (caliper = 0.05), 6,396 ASD patients were matched to 6,396 general population controls. Logistic regression was performed to compute odds ratios (OR) and 95% confidence-intervals (CI) for mental health outcomes. After matching, mean age was 58.0 and 76% were female. Compared to the general population, ASD patients had higher unadjusted rates of depression (37.6% vs. 11.3%), anxiety (41.6% vs. 12.1%), post-traumatic stress disorder (PTSD) (7.2% vs. 2.2%), bipolar disorder (7.1% vs. 2.1%), schizophrenia/psychosis (2.4% vs. 0.9%), substance use disorders (24.3% vs. 9.7%), eating disorders (1.4% vs. 0.4%), and attention-deficit hyperactivity disorder (ADHD) (5.3% vs. 1.4%). On logistic regression, ASD patients had higher odds of depression (OR=2.06, CI=1.90-2.23, P<0.001), anxiety (OR=2.24, CI=2.07-2.43, P<0.001), and ADHD (OR=2.87, CI=2.32-3.54, P<0.001). ASD patients also exhibited significantly elevated odds for eating disorders, bipolar disorder, PTSD, and substance use disorder (P<0.05). ASD patients in the United States have a substantially elevated mental health burden than the general populace. Routine mental health screenings and psychological assessments can be beneficial for this vulnerable population.
- Notes:
- Scholarly concentration: Biomedical Informatics
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- Attribution 4.0 International (CC BY 4.0)
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Citation
Mehta, Tanmay, Singh, Manjot, Farias, Michael, et al.,
"National Mental Health Burden in Adults with Spinal Deformity: A Propensity-Matched Analysis Using the All of Us Research Program"
(2025).
Warren Alpert Medical School Academic Symposium.
Brown Digital Repository. Brown University Library.
https://repository.library.brown.edu/studio/item/bdr:mq3afqvw/
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Warren Alpert Medical School Academic Symposium
The Warren Alpert Medical School Academic Symposium is an annual event at Warren Alpert Medical School of Brown University that provides Year II medical students a venue to present their summer research in a poster format. Participation in the Symposium …...