Plasma Biomarker Concentration Changes in a Sample of Non-treatment Seeking, Young, Heavy Alcohol Consumers Who Used a Probiotic Supplement for 30 Days

Negash, Seraphina

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Overview

Year:: 2023
Contributor:: Negash, Seraphina (creator); Monnig, Mollie (Advisor); Madsen, Tracy (Reader); Brown University. School of Public Health (sponsor)
Genre:: theses
Subject:: Clinical trials
Extent:: 6, 28 p.

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Description

Abstract:: In 2019, 14.1 million adults reported they had alcohol use disorder (AUD) in the National Survey on Drug Use and Health. AUD is associated with significant psychological and physical comorbidities and can lead to death. Previous research has found that probiotics are effective in reducing inflammatory markers in persons with AUD and chronic conditions such as cirrhosis of the liver. This relationship has not been explored in alcohol users without progressed disease. In a proof-of-concept study,16 young, heavy alcohol users without known comorbidities received a 30-day course of daily probiotic supplement. Eligible participants met NIAAA guidelines for heavy alcohol use and did not have any pre-existing medical problems. Each participant received four blood draws- prior to the intervention, mid-intervention, at the end of the intervention, and after a 30 day washout period. Immunoassay was conducted on the blood samples to observe concentrations of 7 key biomarkers: CD-14, IL-6, IL-8, IL-10, LBP, MCP-1, CD-163 and TNF-. A linear mixed model was used to observe within-subjects changes in biomarker concentrations over the intervention period, with biological sex and alcohol use included as time-varying covariates. Analysis was conducted in SAS 9.4 using the proc mixed command. There was no significant change in biomarker concentrations over the study period. Number of heavy drinking days was associated with increased concentrations of IL-6 and IL-8. Days since last drink was associated with a decreased concentration of MCP-1. While probiotics have been effective in decreasing inflammation in heavy alcohol consumers with chronic disease, there was not a significant association in this sample.
Notes:: Thesis (M. P. H.)--Brown University, 2023

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Citation

Negash, Seraphina, "Plasma Biomarker Concentration Changes in a Sample of Non-treatment Seeking, Young, Heavy Alcohol Consumers Who Used a Probiotic Supplement for 30 Days" (2023). Public Health Theses and Dissertations. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:nd79yy7j/

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Public Health Theses and Dissertations

Theses and Dissertations for the Public Health department.
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