Description
- Abstract:
- Gold nanorods (AuNRs) enable remote neuronal activation via photothermal effects, but their systemic safety after ocular delivery is not well defined. We evaluated systemic toxicity in mice for 32 days after intravitreal injection of three AuNR formulations: 25-nm Thy-1–conjugated AuNRs, 10-nm Thy-1–conjugated AuNRs (size effect), and 25-nm bare AuNRs (surface chemistry effect), with phosphate-buffered saline as control. Hematology, serum biochemistry, and body weight were measured at 2, 8, and 32 days post-injection. Thy-1–conjugated AuNRs produced no significant changes in serum indices or blood counts versus controls, indicating no detectable systemic toxicity. In contrast, bare AuNRs increased uric acid by 23% (p = 0.0018), suggesting systemic effects when targeting is absent. Age and sex influenced several baseline hematologic and biochemical measures. Overall, Thy-1–conjugated AuNRs appear systemically safe through 32 days, underscoring the value of targeted nanoparticle design to reduce toxicity risk.
- Notes:
- This research is funded by the NIH National Eye Institute under award R01EY030569.
Access Conditions
- Use and Reproduction
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- This work is licensed under a GNU GPL3 License
- Rights
- In Copyright
Citation
Lee, Jonghwan,
"MATLAB script to analyze blood test data of intravitreally injected gold nanorods"
(2025).
Brown University Open Data Collection, (NIH R01EY030569) Plasmonic Retinal Prosthesis.
Brown Digital Repository. Brown University Library.
https://doi.org/10.26300/ng6g-hj56
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Brown University Open Data Collection
This collection contains open and public access data sets created by Brown University faculty and student researchers. Increasingly, publishers and funders are requiring that protocols, data sets, documentation and code underlying publications be retained and preserved in repositories, their locations …... -
(NIH R01EY030569) Plasmonic Retinal Prosthesis
This collection is for the preservation and public dissemination of Lee Lab's digital research data and code files created and collected under the NIH National Eye Institute-funded project "Plasmonic Retinal Prosthesis" (NIH R01EY030569). Please cite the digital object identifier (DOI) …...