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Items (21-40) out of 87 results

Cellular and Circuit Effects of Chemogenetic Neuronal Stimulation

Description:
Chemogenetic modulation of neuronal populations allows for precise control over cells engineered to express an exogenous receptor that responds exclusively to specific molecules. Chemogenetic approaches …
Year:
2022
Contributor:
Patel, Jeel (Author)
Crespo, Emmanuel L. (Author)
Knoblock, Macy (Author)
Tree, Maya (Author)
Riselay, Kathleen (Author)
Ikefuama, Ebenezer (Author)
Prakash, Prakash (Author)
Hochgeschwender, Ute (Author)
Subject:
Bioluminescence
Optogenetics
Chemogenetics
neuron characteristics
neuronal stimulation
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Code, Data, and Materials for publication: Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

Description:
In addition to the zip file please see the embedded videos in the section at the bottom of the record labeled Relations
Year:
2023
Contributor:
Celinskis, Dmitrijs (Creator)
Moore, Christopher I. (Creator)
Subject:
neuroimaging
Collection:
Brown University Open Data Collection
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Cold Light

Description:
This video was created as an educational tool to disambiguate bioluminescence, fluorescence, and phosphorescence.
Year:
2019
Contributor:
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Cold Light (No Narration)

Description:
This video was created as an educational tool to disambiguate bioluminescence, fluorescence, and phosphorescence.
Year:
2019
Contributor:
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Cold Light (No Narration)

Description:
This video was created as an educational tool to disambiguate bioluminescence, fluorescence, and phosphorescence.
Year:
2019
Contributor:
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Controlling neuron-muscle communication with biological light

Description:
Interluminescence is a method for selective modulation of synaptic communication between genetically defined partners. Bioluminescent light from a pre-synaptic released luciferase activates a post-synaptic localized …
Year:
2022
Contributor:
McLean, Lily (Creator)
Prakash, Mansi (Creator)
Crespo, Emmanuel L. (Creator)
Hochgeschwender, Ute (Creator)
Subject:
Bioluminescence
interluminescence
Lambert-Eaton Myasthenic Syndrome
neuromuscular junction
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Cortical hyperexcitation in early development results in autistic behavioral phenotypes

Description:
Using optogenetics, we can manipulate neuronal activity using light. Due to the young age of the animals used in this study, a non-invasive light source …
Year:
2018
Contributor:
Medendorp, William (Creator)
Waddell, Madison (Creator)
Pal, Akash (Creator)
Hochgeschwender, Ute (Creator)
Subject:
BL-OG
Bioluminescence
LMO3
luminopsin
Optogenetics
development
autism
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Available to Brown-affiliated users only
Full Record

Data for CaBLAM! A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase

Description:
In vivo imaging data for CaBLAM manuscript. To download these data please click on the red download link below labeled “Download Using Globus” and set …
Year:
2025
Contributor:
Lambert, Gerard G. (Author)
Crespo, Emmanuel L. (Author)
Murphy, Jeremy (Author)
Turner, Kevin (Author)
Gershowitz, Emily (Author)
Cunningham, Michaela (Author)
Boassa, Daniela (Author)
Luong, Selena (Author)
Celinskis, Dmitrijs (Author)
Allen, Justine J. (Author)
Venn, Stephanie (Author)
Zhu, Yunlu (Author)
Karadas, Mürsel (Author)
Chen, Jiakun (Author)
Marisca, Roberta (Author)
Gelnaw, Hannah (Author)
Nguyen, Daniel D. (Author)
Hu, Junru (Author)
Sprecher, Brittany N. (Author)
Tree, Maya O. (Author)
Orcutt, Richard (Author)
Heydari, Daniel (Author)
Bell, Aidan B. (Author)
Torreblanca-Zanca, Albertina (Author)
Hakimi, Ali (Author)
Czopka, Tim (Author)
Shoham, Shy (Author)
Nagel, Katherine I. (Author)
Schoppik, David (Author)
Andrade, Arturo (Author)
Lipscombe, Diane (Author)
Moore, Christopher I. (Author)
Hochgeschwender, Ute (Author)
Shaner, Nathan C. (Author)
Subject:
Bioluminescence
Ca2+
Oplophorus gracilirostris luciferase
Globus
Collection:
Brown University Open Data Collection
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Developmental Stimulation of Pyramidal Neurons During a Defined Temporal Window Alters Single Unit Activity in Adult Mice

Description:
The malformation of neuronal circuitry in the developing neocortex leads to a variety of psychiatric disorders later in the organism’s life. By investigating alterations in …
Year:
2022
Contributor:
Maharjan, Shashwat (Author)
Crespo, Emannuel L. (Author)
Riselay, Kathleen (Author)
Hochgeschwender, Ute (Author)
Subject:
Bioluminescence
Optogenetics
development
psychiatric disorder
neocortex
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Distinct Advantages of BioLuminescence for Neuroscience

Description:
This digital poster created for the 2021 BRAIN Initiative Investigators Meeting provides an overview of the advantages of bioluminescence for neuroscience research. Our BioLuminescent-OptoGenetics (BL-OG) …
Year:
2021
Contributor:
Moore, Christopher I. (Author)
Lipscombe, Diane (Author)
Hochgeschwender, Ute (Author)
Shaner, Nathan C. (Author)
Allen, Justine J. (Author)
Subject:
Bioluminescence
undergraduate education
Optogenetics
interluminescence
luciferin
calcium
Luciferase
Chemogenetics
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Dr. Mansi Prakash In the Lab

Description:
In this video, Dr. Mansi Prakash describes her career path and the techniques she learned in order to pursue her research questions. The introduces interluminescence …
Year:
2021
Contributor:
Prakash, Mansi (Creator)
Subject:
Bioluminescence
interluminescence
opsin
cell signaling
neural communication
STEM education
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OER) and Research Impacts
Full Record

Effects of Hyperexcitation of Layer V Neocortical Pyramidal Neurons During Early Postnatal Development on Adult Behavior

Description:
Patterns of neuronal activity during early development are believed to guide the assembly of neural circuits. Thus, alterations of neuronal activity in this time window …
Year:
2022
Contributor:
Uprety, Anusha (Author)
McLean, Lily (Author)
Maharjan, Shashwat (Author)
Folkert, Grant (Author)
Riselay, Kathleen (Author)
Ikefuama, Ebenezer (Author)
Crespo, Emmanuel L. (Author)
Hochgeschwender, Ute (Author)
Subject:
Bioluminescence
Optogenetics
development
autism
Behavior
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Full Record

Flourescence, Phosphorescence, and Bioluminescence

Description:
This gif was created as an educational tool to disambiguate bioluminescence, fluorescence, and phosphorescence.
Year:
2019
Contributor:
Khan, Raisa (Creator)
Subject:
Broader Impacts
Bioluminescence
education
fluorescence
phosphorescence
outreach
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Fluorescence and Bioluminescence: Basics and Chemistry

Description:
This recorded lecture introduces undergraduate students to the chemistry of bioluminescence and fluorescence. The lecture explains how new fluorescent proteins are discovered, whether in nature …
Year:
2021
Contributor:
Shaner, Nathan (Author)
Subject:
Bioluminescence
Undergraduate Education
imaging
fluorescence
Fluorescent Proteins
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Freely moving Cacna1hChR2eYFP+/- animal following two independent surgical procedures for brain and spinal cord window implantations from Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

Description:
An examle of freely moving Cacna1hChR2eYFP+/- animal following two independent surgical procedures for brain and spinal cord window implantations (procedure VI in Fig. 7). At …
Year:
2024
Contributor:
Celinskis, Dmitrijs (Creator)
Subject:
Brain
spinal cord
Behavior
miniscope
multi-organ imaging
implantable window
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Full Record

Freely moving Trpv1ChR2eYFP+/-animal following two independent surgical procedures for spinal cord and brain window implantations from Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

Description:
An examle of freely moving Trpv1ChR2eYFP+/-animal following two independent surgical procedures for spinal cord and brain window implantations (procedure VI in Fig. 7). At the …
Year:
2024
Contributor:
Celinskis, Dmitrijs (Creator)
Subject:
Brain
spinal cord
Behavior
multi-organ imaging
implantable window
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Full Record

From Shrimp to Brain

Description:
This recorded lecture introduces undergraduate students to genetic engineering, the creation of molecular constructs, laboratory techniques for in vitro study and viral transduction for in …
Year:
2021
Contributor:
Hochgeschwender, Ute (Author)
Subject:
BL-OG
LMO3
Molecular Engineering
Molecular Biology
Undergraduate Education
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Open Educational Resources (OERs) and Advancing Research Impacts
Full Record

Full ICV Coordinate Table

Description:
List of positions anterior-posterior positions relative to Bregma, as well as depth relative to skull mark and distance left to advance the electrode (along the …
Year:
2018
Contributor:
Klein, Eric (Creator)
Subject:
Injections, Intracerebroventricular
Cannula
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Available to Brown-affiliated users only
Full Record

Growin’ Glowin’ FUNGI: Grow your own bioluminescent fungus

Description:
This activity is designed for children ages 8-12 and will introduce them to the basics of bioluminescence and bioluminescent fungi. Learners will have the opportunity …
Year:
2019
Contributor:
Literman, Krystal (Creator)
Subject:
Broader Impacts
Bioluminescence
education
outreach
STEM practices
fungi
Collection:
Open Educational Resources (OERs) and Advancing Research Impacts
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Educational and Engagement Materials
Full Record

Imaging data for Lambert et al. "Aequorea’s secrets revealed: new fluorescent proteins with unique properties for bioimaging and biosensing"

Description:
Using mRNA-Seq and de novo transcriptome assembly, we identified, cloned and characterized nine previously undiscovered fluorescent protein (FP) homologs from Aequorea victoria and a related …
Year:
2020
Contributor:
Shaner, Nathan C. (Author)
Subject:
fluorescent protein
chromoproteins
Green fluorescent protein (GFP)
Aequorea
Collection:
NeuroNex Technology Hub: Bioluminescence for Optimal Brain Control and Imaging
NeuroNex Data and Research Products
Brown University Open Data Collection
Full Record

Items (21-40) out of 87 results