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Description:: This work discusses the unique tribological and anti-inflammatory properties of the glycoprotein lubricin in relation to arthritis. The first aim investigates changes in friction and …
Year:: 2017
Contributor:: Larson, Katherine Marie (creator); Darling, Eric (Reader); Elsaid, Khaled (Reader); Tripathi, Anubhav (Reader); Jay, Gregory (Advisor); Fleming, Braden (Reader); Crisco, Joseph (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Osteoarthritis; Lubricin; Articular cartilage; Tribology; Arthritis
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Coordinated migration patterns emerge from the interactions of discrete individuals, ranging from self-propelled particles and mammalian cells at the microscopic scale to robots and animals …
Year:: 2021
Contributor:: Bhaskar, Dhananjay (creator); Wong, Ian (Advisor); Crawford, Lorin (Reader); Darling, Eric (Reader); Sandstede, Bjorn (Reader); Zenit, Roberto (Reader); Ziegelmeier, Lori (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Machine Learning; agent-based models; topological data analysis; Collective behavior
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Microsphere drug delivery systems still face many hurdles specific to gastrointestinal uptake. Human physiological components are difficult to properly emulate and test without the usage …
Year:: 2021
Contributor:: Jones, Carder Leigh Edward (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Morgan, Jeffrey (Reader); Schell, Jacquelyn (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Particle Tracking Velocimetry; Biotechnology; Drug delivery systems; Polymeric nanoparticles; diffusion coefficient; Glycoproteins
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Tribology is the study of friction, wear, and lubrication. For the past several decades, the engineering principles of tribology have been used in attempts to …
Year:: 2011
Contributor:: Drewniak, Elizabeth I (creator); Crisco, Joseph (Director); Jay, Gregory (Reader); Fleming, Braden (Reader); Darling, Eric (Reader); Guilak, Farshid (Reader); Brown University. Biomedical Engineering (sponsor)
Genre:: theses
Subject:: coefficient of friction; lubricin; mouse knee; Articular cartilage; Pendulum; Osteoarthritis
Language:: English
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: The research presented in this thesis aims to advance our understanding of cellular behavior in physiologically relevant environments composed of single cues or multiple cues. …
Year:: 2013
Contributor:: Lopez-Fagundo, Cristina Y (creator); Hoffman-Kim, Diane (Director); Morgan, Jeffrey (Reader); Darling, Eric (Reader); Franck, Christian (Reader); Kuntz Willits, Rebecca (Reader); Brown University. Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Schwann cells; micromolding; mouse embryonic stem cells; Polyacrylamide
Language:: English
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug resistant cancers. …
Year:: 2020
Contributor:: Xuan, Botai (creator); Dawson, Michelle (Advisor); Darling, Eric (Reader); Sedivy, John (Reader); Janmey, Paul (Reader); Anthony, Douglas (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Biophysics; Cell migration; Polyploidal giant cancer cells; vimentin; cancer cell invasion
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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Description:: The placenta plays a crucial role during pregnancy, yet it remains one of the least understood human organs. Trophoblast cells comprise the placenta with functions …
Year:: 2020
Contributor:: Bailey-Hytholt, Christina Mary (creator); Shukla, Anita (Advisor); Tripathi, Anubhav (Advisor); Darling, Eric (Reader); Wessel, Gary (Reader); Kraus, Morey (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomedical engineering; Prenatal diagnosis; women's health; Bilayer lipid membranes; Liposomes; Placenta
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: This thesis highlights our advances across many disciplines developing a fully implantable, low power, broadband, and wireless neural recording platform for use in persons with …
Year:: 2012
Contributor:: Borton, David Allenson (creator); Nurmikko, Arto (Director); Donoghue, John (Reader); Tripathi, Anubhav (Reader); Darling, Eric (Reader); Denison, Timothy (Reader); Brown University. Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Neuroengineering; Brain-Machine Interface; Neuroprosthetics; Neurosciences; Brain-computer interfaces
Language:: English
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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