The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Aberrant endothelial cell (EC) proliferation plays an important role in the vascular remodeling observed in Pulmonary Arterial Hypertension (PAH). Anoctamin-1 (Ano1), a calcium activated chloride …
Aging is associated with an increased risk of arrhythmias and sudden cardiac death (SCD). Yet, much remains unknown about the mechanisms that underlie the age-related, …
Aspartyl-asparaginyl-β-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). …
Background: Chronic alcoholic liver disease is associated with hepatic insulin resistance, inflammation, oxidative and ER stress, mitochondrial dysfunction, and DNA damage. Peroxisome proliferator activated receptor …
Head and neck squamous cell carcinoma (HNSCC) afflicts over half a million new patients each year. The major risk factors for developing this disease include …
Given the increasing worldwide energy demand and the finite supply of fossil fuels, the development of renewable energy sources is of global importance. The use …
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates that is associated with numerous physiological functions. A7-nAChR has been reported …
In mammals the natural pigment melanin gives color to the skin, eyes, and hair, and provides protection against harmful solar ultraviolet radiation (UVR). Despite its …
In the spinal cord dorsal horn, persistent changes in synaptic strength may contribute to nociceptive information processing and to pathological pain states. These changes overlap …
Nicotinic acetylcholine receptors (nAChRs) mediate excitatory neurotransmission at synapses throughout the body in the neuromuscular junction and the central nervous system. The two basic types …
Abstract of Mechanisms of Melanopsin Photoresponse Termination: Biochemical Analysis of the Intrinsically Photosensitive Retinal Ganglion Cell Photopigment, by Courtney E. Frederick, Ph.D., Brown University, May …
A preponderance of evidence supports the assertion that low-grade inflammation resulting from exposure to ELS is associated with poor health outcomes in adulthood. To better …
The α7 nicotinic acetylcholine receptor (α7 nAChR), a ligand-gated ion channel whose involvement in numerous neurological and somatic pathologies makes it a target of considerable …
Sigma receptors are a unique pharmacologically defined class of drug-binding proteins comprised of the sigma-1 and sigma-2 subtypes. These subtypes are differentiated by their pharmacological …
Bacterial biofilms underlie the recalcitrance of many harmful infections to antibiotic treatment. One strategy that allows biofilms to evade antibiotics is the presence of a …
With increasing understanding of how the mechanics of individual cells and groups of cells influence cell function, an appreciation for the arrangement of cells in …
Mitogen-activated protein kinases direct the cellular response to environmental and developmental signals. MAPKs are activated through kinase modules resulting in phosphorylation of the MAPK on …