Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a …
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is estimated to affect as many as 1 in 88 children. Epilepsy is a common …
Epilepsy is the most common neurological disorder affecting a significant portion of the United States (Kabat and Przemysław 2012). The involvement of Circadian Locomotor Output …
Abstract of “Contributions to the Relationship Between Circadian Rhythm Protein Dysfunction and Epilepsy—CLOCK and the PAR bZIP Transcription Factors” by Luis Antonio Goicouria, Ph.D., Brown …
Normal brain development, involving neuronal migration, polarity and differentiation, requires synaptic trafficking of essential cargo. These cargo are primarily transported on microtubules (MTs), which play …
Christianson syndrome (CS) is an autism-related rare genetic disorder due to changes in the SLC9A6 gene. A CS research registry of patients began in 2017 …
Both epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES) are severely debilitating conditions that are frequently encountered in neurology and psychiatry. Based on a psychotherapy …
Epilepsy is a common neurological disorder characterized by the recurrence of spontaneous seizures. However, the mechanisms of transition into seizures are still unclear. A better …
Early Infantile Epileptic Encephalopathy is a neurodevelopmental disorder characterized by severe epilepsy, with seizure onset during infancy or childhood. It is caused by a mutation …
Although Type I lissencephaly is one of the most severe cortical malformation disorders and is highly comorbid with epilepsy, the cellular and circuit mechanisms driving …
Epilepsy affects over 3 million people in the United States alone. In many of those cases, the disease is refractory to medication, leaving patients limited …
Mutations in the SLC13A5 gene, which encodes a plasma membrane citrate transporter, result in developmental epileptic encephalopathy (DEE25), a disorder characterized by infantile multi-focal seizures, …
Epilepsy is a complex neurological disorder characterized by recurrent seizures, affecting millions worldwide. Understanding the molecular mechanisms underlying epilepsy pathogenesis is crucial for developing effective …
Abstract: Importance: Surgical intervention is a well-established modality for achieving near or full seizure freedom and improved quality of life for people with intractable epilepsy …