Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Chromothripsis is a novel mutational phenomenon that is initiated when a chromosome becomes trapped in a micronucleus, a small structure created by abnormal cell division. …
The growing interest in genealogy for African Americans is one expression of a longstanding desire to find answers to questions about ancestors, family, and heritage …
Manual curation of primary literature is a common, time-intensive approach for identifying genes associated with a disease of interest. This project aims to minimize the …
A crucial challenge facing medical students is to maintain a curious, flexible, patient-oriented state of mind, in the face of overwhelming quantities of depersonalized course …
KMT2A-translocations are seen in 5-10% of patients with leukemia, but it is present in approximately 50% of pediatric AML diagnoses. Acute leukemias carrying chromosomal translocations …
The 3D nuclear organization plays a crucial role in cellular functions via gene regulation. While many techniques like HiC, microC, and HiChIP have revealed the …
In all organisms, gene regulation is crucial for proper cell function and development. Dosage compensation is one such mechanism of gene regulation. In Drosophila melanogaster, …
Motor neurons are a class of post-mitotic cells expected to survive for the duration of the human lifetime. While other cells routinely undergo programmed cell …
Christianson syndrome (CS) is an autism-related rare genetic disorder due to changes in the SLC9A6 gene. A CS research registry of patients began in 2017 …
Nearly 4 million pregnant persons receive prenatal care in the United States annually, and current recommendations from the American College of Obstetricians and Gynecologists (AGOG) …
Single cell RNA sequencing (scRNA-seq) is a recently developed technology that enables the quantification of RNA transcripts at individual cell level, providing cellular level resolution …
Abstract of Disruption of yfjD Gene in Francisella, by Japheth Omonira, ScM., Brown University, May 2018. Francisella tularensis is the causative agent of tularemia, a …
Head and neck squamous cell carcinoma (HNSCC) afflicts over half a million new patients each year. The major risk factors for developing this disease include …
Epigenetics are important in the precise lineage organization of the immune system because they can create stable, heritable expression profiles. These epigenetic mechanisms, such as …
Alcohol use disorder (AUD), defined as prolonged alcohol consumption despite negative consequences, is fundamentally a disease of associative memory. Individuals with AUD form short-term aversive …
Retrotransposable element (RTE) mobilization due to heterochromatin loss is among the molecular mechanisms associated with deleterious phenotypes that accompany biological aging. Here, we describe novel …
