Myeloid-derived suppressor cells (MDSCs) are an immunosuppressive, heterogeneous population of cells upregulated in cancer and other pathologic conditions. DNA methylation (DNAm) is well known to …
The research presented in this thesis aims to examine the role of varied cadherin expression on transformed cells and how this impacts disease severity and …
Natural killer (NK) cells are innate lymphocytes essential for host defense against viral infections and cancer. They recognize and eliminate cells termed ‘altered self’ based …
Abstract of Disruption of yfjD Gene in Francisella, by Japheth Omonira, ScM., Brown University, May 2018. Francisella tularensis is the causative agent of tularemia, a …
Host-microbe interactions heavily influence both fitness and disease. Traditionally, research on host-microbe interactions focused on the concept that microbes only contribute to pathogenesis. However, recent …
Innate lymphoid cells (ILCs) are diverse innate lymphocytes that contribute to the immune response against pathogens and cancer cells, and play a variety of roles …
Cellular immunotherapy is a type of treatment available to cancer patients where the immune system is utilized to combat tumors. In a previous clinical trial, …
The immune dysfunction induced by alcohol use has severe and devastating health consequences. Despite extensive research characterizing the widespread effects of alcohol consumption on the …