X-linked dystonia Parkinsonism (XDP) is a rare movement disorder that occurs predominantly in men with ancestry to Panay Island, Philippines. In a local clinic in …
Increased oscillations and synchronized behavior in the Subthalamic Nucleus (STN) and nearby structures have been linked to the progression of Parkinson’s Disease (PD), and this …
Parkinson’s Disease (PD) is one of the most common neurodegenerative disorders. A small percentage of people with PD have a heritable form of the disease, …
Objective: Deep brain stimulation (DBS) has become a widely adopted treatment for the advanced progression of Parkinson’s disease (PD) and is thought to modulate the …
Beta oscillations are neural rhythms in the range of 15-29 Hz that are powerful indicators of motor and sensory performance. Beta oscillations are thought to …
Introduction: We sought to identify the neural signatures of fluctuating symptoms in Parkinson’s Disease (PD) using a convolutional neural network (CNN) trained to classify motor …
The applications of convolutional neural networks (CNN) are nearly endless. As a popular method for image classification, they have demonstrated the ability to categorize Parkinson’s …
Among the many possible motor- and non-motor symptoms that patients with Parkinson’s Disease (PD) may experience, there are several that do not respond well to …
Parkinson’s disease (PD) is a debilitating, progressive neurological disease that involves the degeneration of dopaminergic neurons. Incidence and prevalence of the disease increases with age. …
The Neutrophil-to-Lymphocyte Ratio (NLR) is a biomarker that reflects peripheral inflammation. Higher NLR has been linked to several neurodegenerative disorders, including idiopathic Parkinson’s Disease (PD), …
The insulin (IR) and insulin-like growth factor receptors (IGF-IR) are critical mediators of growth, development and survival. Given their immense biological significance, a complex system …
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by distinct motor symptoms such as tremor, bradykinesia, and rigidity. These symptoms present heterogeneously across patients …
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by degeneration of the nigrostriatal tract (NST), a dopaminergic neural pathway involved in motor control and links …
Parkinson’s Disease (PD) severity is captured by the Unified Parkinson’s Disease Rating Scale (UPDRS), which is used to determine two motor subtypes of PD—Tremor Dominant …
Neurodegenerative diseases are a group of etiologically heterogeneous diseases characterized by the loss of a vulnerable subset of neurons. Despite this heterogeneity in etiology, TDP-43 …
Magnetic resonance (MR) has expanded over the past few decades into exciting new applications that have advanced the diagnosis, evaluation and treatment of many diseases. …
Abstract of Neural Biomarker Based Parameter Optimization Using Deep Brain Stimulation for Parkinson’s Disease, by Pranav Akella, ScM., Brown University, May 2022. Introduction: Parkinson’s Disease …
Deep brain stimulation (DBS) is an effective treatment for the mid/late stage Parkinson’s disease (PD), which significantly reduces the dopamine medication and improves motor symptoms. …
The phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is essential for cell survival, growth, proliferation, and differentiation. It is highly conserved and …
Introduction: The basal ganglia, including the subthalamic nucleus (STN), plays a key role in the pathogenesis of Parkinson's Disease (PD). Beta field activity (12-30Hz) is …
