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Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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  • 26 2024

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Items (1-20) out of 26 results

An Experimental Study of a Flexible, Self Healing Strain Sensor

Description:
Wearable health monitors represent an essential area of research in biomedical engineering, where strain sensors play a major role in enabling effective and continuous health …
Year:
2024
Contributor:
Simon, Dashaun (creator)
Gray, Marissa (Reader)
Mathiowitz, Edith (Reader)
Srivastava, Vikas (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomechanics
Solid Mechanics
Biomedical engineering--Research
Biosensors
Structural health monitoring
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Artificial Intelligence for Sleep Apnea Detection and Prediction from Electrocardiograms

Description:
Sleep apnea is a common, yet underdiagnosed, sleep-related breathing disorder associated with increased risk of cardiovascular issues. This work uses a multifaceted approach integrating artificial …
Year:
2024
Contributor:
Gatsonis, Achilles Nicholas (creator)
Karniadakis, George (Advisor)
Chu, Antony (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Machine Learning
Obstructive Sleep Apnea
Artificial intelligence
Deep Learning
Electrocardiographs
Apnea
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Assessing the Microenvironment Recapitulation Capabilities of a 3D-Printed Ovarian-Tumoroid-on-a-Chip Via PARP-inhibitor Response

Description:
When diagnosed in late stages, ovarian cancer is one of the deadliest forms of gynecological cancer. In order to increase the likelihood that a patient …
Year:
2024
Contributor:
Walters, Nondi Lia (creator)
Tripathi, Anubhav (Advisor)
Darling, Eric (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
chemotherapeutics
Three-dimensional printing
epithelial ovarian cancer
ovarian cancer
Tumor Microenvironment
LCMS
organ on a chip
tumor on a chip
parp inhibitors
olaparib
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Biomechanical Properties Maintained in 3D Microtissue Rings when Developing Ligament-Like Constructs

Description:
Tendon and ligament injuries display poor healing capacities from the formation of scar-like tissue resulting in decreased mechanical properties. The application of biomechanics, the study …
Year:
2024
Contributor:
Shaffer, Abigail (creator)
Morgan, Jeffrey (Advisor)
Horrigan, Diana (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Biomechanics
tissue engineering
Fibroblasts
microtissue
Cell culture
Ligaments
3D Cell Culture
in vitro
tensile testing
tensile properties
uterosacral ligament
Connective tissues
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Characterization of Nucleic Acid Delivery Vehicle Products using Microfluidic Concepts

Description:
In recent years, there has been an exponential growth in biopharmaceutical development stemming from its ability to treat previously incurable diseases and to go from …
Year:
2024
Contributor:
Coll De Peña, Adriana (creator)
Tripathi, Anubhav (Advisor)
Darling, Eric (Reader)
Shukla, Anita (Reader)
Hurt, Robert (Reader)
Wong, Ian (Reader)
Goswami, Somdatta (Reader)
Bailey-Hytholt, Christina (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Microfluidics
Electrophoresis
Biopharmaceuticals
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Clinical Considerations for a Minimally Invasive Wireless EEG System

Description:
This thesis aims to contribute to the practical deployment of a new type of multichannel subdermal wireless EEG system under development at the Nurmikko Lab …
Year:
2024
Contributor:
Chhabra, Akshit (creator)
Nurmikko, Arto (Advisor)
Berson, David (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Neuroengineering
Microfabrication
data science
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Developing Methods for Perinatal Health Screening

Description:
Screening for maternal and prenatal health conditions allows for better patient care and improved health outcomes. In maternal health, hypertensive conditions like preeclampsia, which leads …
Year:
2024
Contributor:
Piserchia, Jennifer (creator)
Tripathi, Anubhav (Advisor)
Wessel, Gary (Reader)
Raimondo, Theresa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Perinatal Health
Preeclampsia
Biochemical markers
diagnostics
Aneuploidy
Genetic screening
NIPT
NIPS
Diagnosis, Noninvasive
Biological assay
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Development and Validation of a Graph Theory Based Computational Analysis Tool for Investigating Neuronal Network Integrity in 3D Cortical Microtissue Models Under Vincristine Treatment and Ischemic and Ischemia-Reperfusion Conditions

Description:
The thesis introduces a novel computational tool developed using graph theory and implemented in Wolfram Mathematica to analyze neuronal network integrity within three-dimensional cortical microtissues. …
Year:
2024
Contributor:
Burgess, Amina Zohor (creator)
Hoffman-Kim, Diane (Advisor)
Gray, Marissa (Reader)
González-Cruz, Rafael (Reader)
Kesari, Haneesh (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
tissue engineering
Algorithms
engineered tissue
computational analysis
Graph theory
Toxicity testing--In vitro
3D Cell Culture
Neuroscience
Hypoxic-ischemic brain injury
Image analysis--Data processing
Vincristine
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Enhancing Next-Generation Sequencing Library Preparation Efficiency by Integrating RNA-Based Methods and Comprehensive Automation Approaches

Description:
The use of RNA for diagnosis and treatment becomes more rampant with each passing day. One of the main techniques used to analyze RNA is …
Year:
2024
Contributor:
Figueroa-Cruz, Jennifer N. (creator)
Tripathi, Anubhav (Advisor)
Raimondo, Theresa (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Automation
High-throughput nucleotide sequencing
Total RNA
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Feasibility Study of Polarimetric 'Sweat-Sensing' of Glucose

Description:
Blood sugar is an important biomarker in the diagnosis and management of diabetes mellitus. Current sensing methods are invasive, painful, intermittent, and require complex chemical …
Year:
2024
Contributor:
Min, Seokkee (creator)
Toussaint, Kimani (Reader)
Xu, Jimmy (Advisor)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Diabetes
Optics
Biosensing
Sucrose
Polarimetry
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Hallmark Mutation Effects on Epithelial Ovarian Cancer Phenotype and Tumor Microenvironment Interactions

Description:
Ovarian cancer is a rare but deadly disease. Patients are often diagnosed at late-stage, metastatic conditions, resulting in a poor survival rate. High-grade serous carcinoma …
Year:
2024
Contributor:
Quinones, Jacqueline (creator)
Dawson, Michelle (Advisor)
Wong, Ian (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Paclitaxel
tp53
Polyploidal giant cancer cells
epithelial ovarian cancer
Tumor Microenvironment
BRCA genes
Cisplatin
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Harnessing Biotransport Phenomena to Simplify Workflow for Clinical Metabolomics using Microsamples

Description:
Despite the existence of metabolomics as a field for nearly two decades, challenges of sample preparation limit the large-scale application and throughput of targeted metabolomics …
Year:
2024
Contributor:
Fariha, Ramisa (creator)
Tripathi, Anubhav (Advisor)
Srivastava, Vikas (Reader)
Mathiowitz, Edith (Reader)
Marshall, John (Reader)
Haass-Koffler, Carolina L. (Reader)
Kingon, Angus (Reader)
Thomas, Stefani (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Pediatrics
Mass spectrometry
Drug abuse
Neonatal Opiod Withdrawal Syndrome
blood diagnostics
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

HCMP Characteristics Assessment for in situ Microenvironmental Force Measurement

Description:
Early tissue formation and regeneration is regulated by mechanical forces. However, few tools exist that can measure such forces in situ in cell-dense structures and …
Year:
2024
Contributor:
Rodriguez Navas, Marta (creator)
Darling, Eric (Advisor)
Morgan, Jeffrey (Reader)
Kesari, Haneesh (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
tissue engineering
mechanobiology
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Inducing Mesophase Morphologies In Isotactic Polypropylene

Description:
This paper investigates the impact of processing conditions, specifically temperature and pressure, on inducing mesophase morphologies in Isotactic Polypropylene (iPP). iPP is a highly valued …
Year:
2024
Contributor:
Sundaresan, Gayathri (creator)
Mathiowitz, Edith (Advisor)
Shukla, Anita (Reader)
Coulombe, Kareen (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Polymer chemistry
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Investigating Cardioprotective Strategies for Doxorubicin-Induced Cardiotoxicity Using a 3D Human iPSC-Cardiomyocyte Microtissue Model

Description:
Chemotherapy is vital in cancer treatment, but its efficacy is often compromised by its cardiotoxic effects, particularly with anthracyclines such as doxorubicin (DOX). DOX-induced cardiotoxicity …
Year:
2024
Contributor:
Basnet, Rojry (creator)
Coulombe, Kareen (Advisor)
Kofron, Celinda (Reader)
Plavicki, Jessica (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Doxorubicin
hiPSC-CM
MicroBundleCompute
Cardiotoxicity
Doxorubicin-Induced Cardiotoxicity
Cardioprotection
Enalapril
Carvedilol
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Investigation and quantification of cell-type diversity in three-dimensional primary cortical tissue model of Alzheimer’s Disease

Description:
Alzheimer’s disease (AD) is the most common form of dementia, estimated to affect over 6 million individuals in the United States in 20241,2. Despite its …
Year:
2024
Contributor:
Drexler, Abigail Rose (creator)
Borton, David (Advisor)
Mayoral, Sonia (Reader)
Huang, Yu-Wen Alvin (Reader)
Morgan, Jeffrey (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Alzheimer's disease
3D Cell Culture
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

LEVERAGING STEREOLITHOGRAPHY 3D-PRINTING CAPABILITIES FOR IN-HOUSE DEVICE FABRICATION

Description:
In order to execute more accurate in vitro studies on human tissues, the mechanical chemical conditions of cell activity must be replicated. This is accomplished …
Year:
2024
Contributor:
Weissberg, Tamsin (creator)
Darling, Eric (Advisor)
Morgan, Jeffrey (Reader)
Wong, Ian (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Three-dimensional printing
Stereolithography
Polydimethylsiloxane
Pressure vessels
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Modeling of Electric Field Enhanced Tissue Dissociation

Description:
This thesis aims to elucidate the understanding of electric field effects on tissue dissociation. To achieve this goal, we designed and developed a comprehensive modeling …
Year:
2024
Contributor:
Tannock, Christopher David (creator)
Triapthi, Anubhav (Advisor)
Mathiowitz, Edith (Reader)
Rosenstein, Jacob (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Sample preparation (Chemistry)
biological tissues
Electric fields
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Modulating Human Cardiac Fibroblast Activation With Hyaluronic Acid Methacrylate Microrods In Three-Dimensional Collagen Hydrogels

Description:
Myocardial fibrosis is a common outcome of adverse cardiac events, such as myocardial infarction, that further accelerates the development of devastating complications, including heart failure. …
Year:
2024
Contributor:
Bellou, Sirine (creator)
Desai, Tejal (Advisor)
Coulombe, Kareen (Advisor)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Nanostructured materials
Myocardial infarction
3D Cell Culture
Biomaterials
Heart--Fibrosis
Myofibroblasts
Hyaluronic acid
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Novel Devices, Physical Mechanisms, and Analytical Techniques for Use in Next Generation Cellular Diagnostics

Description:
Cells are rich in a variety of diagnostic information, from morphology to nucleic acid, protein, and metabolite composition. Cells possess more data than any other …
Year:
2024
Contributor:
Welch, Cel (creator)
Tripathi, Anubhav (Advisor)
Tapinos, Nikos (Reader)
Shukla, Anita (Reader)
Morgan, Jeffrey (Reader)
Rosenstein, Jacob (Reader)
Barabino, Gilda (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biotechnology
Biomedical engineering
diagnostic test
tissue engineering
Cancer
Engineering
Microfluidic devices
Microfluidics
Chemical engineering
Nanotechnology
Medical instruments and apparatus
Artificial intelligence
Computational science and engineering
Biomedical engineering--Research
Diagnosis
Medicine
Biosensing
Molecular diagnosis
cancer screening
diagnostics
Bioengineering
Electrokinetics
Engineering design
Deep learning (Machine learning)
Biosensors
Microelectromechanical systems
Microelectronics
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Items (1-20) out of 26 results