The role of commensal bacteria in regulating Vitamin A metabolism in the gut

Grizotte Lake, Mayara

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Overview

Year:: 2020
Contributor:: Grizotte Lake, Mayara (creator); Brossay, Laurent (Reader); Vaishnava, Shipra (Advisor); Ayala, Alfred (Reader); Jamieson, Amanda (Reader); Brown University. Department of Molecular Microbiology and Immunology (sponsor)
Genre:: theses
Subject:: Epithelial cells; microbiome; gut microbiome; Retinoid X receptors
Extent:: xi, 157 p.

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Description

Abstract:: Vitamin A or retinol is amongst the most well characterized food-derived nutrient with diverse immune-modulatory roles. Deficiency in dietary vitamin A is associated with immune dysfunctions in the gut as well as several systemic immune disorders. In particular, the vitamin A metabolite retinoic acid (RA) has been shown to be crucial in inducing gut tropism in lymphocytes and modulating T helper cell differentiation. In addition to its widely recognized role in adaptive immunity, increasing evidence identifies RA as an important modulator of innate immune cells, such as tolerogenic dendritic cells (DCs) and innate lymphoid cells (ILCs). To maintain sufficient levels of vitamin A, the body relies on the uptake of retinol from the intestinal lumen which is subsequently processed for storage, or it can be further metabolized into RA by specific cells in the intestinal tissue. RA concentration in the intestinal tissue is a major determinant of which type of mucosal immune response will take place. The work presented in my thesis focuses on cellular and molecular mechanisms regulated by RA, and how it shapes immune homeostasis between the host and microbiome.
Notes:: Thesis (Ph. D.)--Brown University, 2020

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Rights: In Copyright
Restrictions on Use: Collection is open for research.

Citation

Grizotte Lake, Mayara, "The role of commensal bacteria in regulating Vitamin A metabolism in the gut" (2020). Pathobiology Theses and Dissertations. Brown Digital Repository. Brown University Library. https://repository.library.brown.edu/studio/item/bdr:1129379/

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Pathobiology Theses and Dissertations

Theses and Dissertations for the Pathobiology department.
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