Injectable Rosette Nanotube Nanomatrix for Localization of Bioactive Protein for Growth Plate Repair

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Overview

Title
Injectable Rosette Nanotube Nanomatrix for Localization of Bioactive Protein for Growth Plate Repair
Contributors
Lam, Peter (creator)
Chen, Yupeng (Advisor)
Darling, Eric (Reader)
Schell, Jacquelyn (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Doi
10.7301/Z0PC30VD
Copyright Date
2017
Abstract
Growth plate fracture is a serious injury that affects children and adolescents. These types of fractures can occur from physical sports, a fall or from overuse. The most common growth plate fractures occur in the phalanges or in the bones in the lower area of the leg such as the tibia and fibula. These fractures can lead to uneven bone growth and bone deformity if left untreated due to bony bridge formation in the cartilage area. The current treatments for growth plate fractures involve immobilization or surgery, depending on the severity of the injury. Surgery involves the removal of the bony bridge and implantation of autologous fat tissue or screws to discourage further bony bridge formation. The disadvantage of surgery is that it is very invasive and is often unsuccessful. Therefore, there is a need for a better therapy to treat growth plate fractures. This study explores a novel therapy using a nanomatrix made up of rosette nanotubes and matrilin-3 to treat growth plate fractures. The aim of this study is to characterize the nanomatrix as well as assess its efficacy in vivo. The results indicate the delivery of matrilin-3 in a matrix with rosette nanotubes is able to sustain the protein inside the injury site longer to prolong its therapeutic effect. Moreover, the results assessing the efficacy of the nanomatrix indicate improved healing of the growth plate fracture by minimizing the degree of bone deformity.
Keywords
Growth plate fracture
Rosette Nanotubes
Matrilin-3
Nanomatrix
Notes
Thesis (Sc. M.)--Brown University, 2017
Extent
v, 33 p.

Citation

Lam, Peter, "Injectable Rosette Nanotube Nanomatrix for Localization of Bioactive Protein for Growth Plate Repair" (2017). Biomedical Engineering Theses and Dissertations. Brown Digital Repository. Brown University Library. https://doi.org/10.7301/Z0PC30VD

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