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Items (1-20) out of 48 results

A Method for Detection and Characterization of Breast Tumors using Ultrasound with CNN

Description:
The goal of this study is to create a simulation-trained convolutional neural network (CNN) that can detect and characterize stiffer tissue embedded in a softer …
Year:
2023
Contributor:
Abulencia, Francesca Denise (creator)
Crisco, Joseph (Reader)
Darling, Eric (Reader)
Srivastava, Vikas (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Machine Learning
Breast--Cancer--Diagnosis
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

A Translational Method to Quantify Anterior Cruciate Ligament Healing Using Magnetic Resonance Imaging for Research and Clinical Applications

Description:
The goal of this thesis was to use non-invasive quantifiable MR parameters of volume, signal intensity and T2* relaxation time to predict the biomechanical or …
Year:
2015
Contributor:
Biercevicz, Alison M (creator)
Fleming, Braden (Director)
Crisco, Joseph (Reader)
Darling, Eric (Reader)
Deoni, Sean (Reader)
Thornton, Gail (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Orthopaedics
MRI
Ligament mechanics
T2* relaxometry
Linear Regression Modeling
Reconstruction
Injury
Orthopedics
Anterior cruciate ligament
Knee
Magnetic resonance imaging
Surgery
Biomechanics
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Analysis of nanostructuredve vs Lipopolysaccharide (LPS) Activated Neutrophil Chemotaxis in 3D Collagen Matrices Using Traction Force Microscopy

Description:
Understanding the fundamental mechanisms, and forces, underlying cell migration holds the promise of effective approaches for treating diseases and promoting cellular transplantation. One such disease …
Year:
2014
Contributor:
Stout, David Andrew (creator)
Franck, Christian (Director)
Reichner, Jonathan (Reader)
Tripathi, Anubhav (Reader)
Darling, Eric (Reader)
Hammer, Daniel (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Traction Force Microscopy
Neutrophil
Chemotaxis
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Assessing the Microenvironment Recapitulation Capabilities of a 3D-Printed Ovarian-Tumoroid-on-a-Chip Via PARP-inhibitor Response

Description:
When diagnosed in late stages, ovarian cancer is one of the deadliest forms of gynecological cancer. In order to increase the likelihood that a patient …
Year:
2024
Contributor:
Walters, Nondi Lia (creator)
Tripathi, Anubhav (Advisor)
Darling, Eric (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
chemotherapeutics
Three-dimensional printing
epithelial ovarian cancer
ovarian cancer
Tumor Microenvironment
LCMS
organ on a chip
tumor on a chip
parp inhibitors
olaparib
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Challenge of the Soft-tissue to Device Interface: A Rheology-based Approach to Biomaterial Development

Description:
Percutaneous implants are a family of devices that penetrate the skin and suffer from infection-mediated device failure caused by lack of integration/adhesion at the skin/device …
Year:
2011
Contributor:
Holt, Brian M (creator)
Morgan, Jeffrey (Director)
Tripathi, Anubhav (Director)
Darling, Eric (Reader)
Mathiowitz, Edith (Reader)
Huang, Helen (Reader)
Brown University. Biomedical Engineering (sponsor)
Genre:
theses
Subject:
human skin
shear
percutaneous device
regression
Skin
Rheology
Regression analysis
Language:
English
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis

Description:
Abstract of ``Characterization of 2D and 3D Models of Particle-Induced Fibrogenesis'' by Alysha E. Simmons, Ph.D., Brown University, October 2020 Pulmonary fibrosis is a chronic, …
Year:
2020
Contributor:
Simmons, Alysha (creator)
Kane, Agnes (Advisor)
Wong, Ian (Advisor)
Morgan, Jeffrey (Reader)
Hurt, Robert (Reader)
Darling, Eric (Reader)
Roxbury, Daniel (Reader)
Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:
theses
Subject:
self-assembled spheroids
Image analysis
Nanomaterial
Fibrosis
Collection:
Biology and Medicine
Pathobiology
Theses and Dissertations
Full Record

Characterization of Nucleic Acid Delivery Vehicle Products using Microfluidic Concepts

Description:
In recent years, there has been an exponential growth in biopharmaceutical development stemming from its ability to treat previously incurable diseases and to go from …
Year:
2024
Contributor:
Coll De Peña, Adriana (creator)
Tripathi, Anubhav (Advisor)
Darling, Eric (Reader)
Shukla, Anita (Reader)
Hurt, Robert (Reader)
Wong, Ian (Reader)
Goswami, Somdatta (Reader)
Bailey-Hytholt, Christina (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Microfluidics
Electrophoresis
Biopharmaceuticals
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Characterizing the Cytotoxic Response of Three-Dimensional Microtissues using Multi-Assay Outputs and Optical Coherence Tomography

Description:
The implementation of functional precision medicine to cancer therapy involves directly examining the efficacy of treatments on patient tumors. This approach has the potential to …
Year:
2025
Contributor:
Zein-Sabatto, Ahbid (creator)
Hoffman-Kim, Diane (Reader)
Lee, Jonghwan (Advisor)
Morgan, Jeffrey (Reader)
Darling, Eric (Reader)
Toussaint, Kimani (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Cancer
Optical coherence tomography
Cell Viability
Multivariate analysis
Functional Precision Medicine
3D in vitro models
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Delivery and safety of gold nanorods for photothermal restoration of vision in blindness

Description:
Electrical retinal prosthetics have been the primary strategy for restoring vision in individuals with blindness, relying on electrical stimulation from implanted electrodes. In this work, …
Year:
2025
Contributor:
AlGhosain, Hafithe M (creator)
Lee, Jonghwan (Advisor)
Darling, Eric (Reader)
Coulombe, Kareen (Reader)
Liu, Tao (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Retinal ganglion cells
Nanomedicine
Toxicology
plasmonic retinal prosthetic
gold nanorods
Retinal prostheses
Vision restoration
Nanoengineering
systemic toxicity
intravitreal injection
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Designing Biomaterials Mimicking Regenerative Extracellular Matrix Cues of the Nervous System

Description:
The work in this dissertation develops two different biomaterial approaches towards advancing our understanding of how neural cell behavior, specifically migration and proliferation, can respond …
Year:
2019
Contributor:
Evans, Elisabeth (creator)
Hoffman-Kim, Diane (Advisor)
Jaworski, Alexander (Reader)
Darling, Eric (Reader)
Mathiowitz, Edith (Reader)
Reichner, Jonathan (Reader)
Brown University. Biology and Medicine: Artificial Organs, Biomaterials, and Cell Technology (sponsor)
Genre:
theses
Subject:
Biomedical materials
Extracellular matrix
Nerves, Peripheral
Collection:
Biology and Medicine
Artificial Organs, Biomaterials, and Cell Technology
Theses and Dissertations
Full Record

Developing and Implementing dPCR Assays for Standardized Mycoplasma Detection at Tessera Therapeutics

Description:
Introduction: Mycoplasma contaminations in cell culture can influence an experiment's reliability and reproducibility, so it’s vital that cultured cells are frequently tested, usually by commercially …
Year:
2025
Contributor:
Banga, Kitti (creator)
Mathiowitz, Edith (Advisor)
Benczkowski, Matthew (Advisor)
Huang, Eric (Reader)
Darling, Eric (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Mycoplasma
dPCR
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Double Wall Polymeric Nanoparticle Carrier for Sustained Release of Biologics in the Gastrointestinal Tract

Description:
Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
Year:
2017
Contributor:
Steranka, Elaine (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Nanoparticles
Drug delivery systems
Polymeric drug delivery systems
Inflammatory bowel diseases
Oral Drug Delivery
Polymeric nanoparticles
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Effect Of Mucin On Hydrodynamic Diameter And Zeta Potential Of Polymeric Nanospheres

Description:
The degree of interaction between nanoencapsulated material and gastrointestinal mucin can be an important determinant in efficiency of absorption of orally delivered therapeutics. Mucus lining …
Year:
2017
Contributor:
Goldenshtein, Victoria (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Oral Drug Delivery
Polymeric nanoparticles
Biological Barriers
Mucin interaction with nanospheres
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Effects of Pressure on the Morphology of Semi-Crystalline Polymers

Description:
When exposed to pressures below and above their glass transition temperature (Tg) and melting temperatures (Tm) over time, both the amorphous and crystalline regions of …
Year:
2016
Contributor:
Baker, Christopher Michael (creator)
Morgan, Jeffrey (Reader)
Mathiowitz, Edith (Advisor)
Tripathi, Anubhav (Reader)
Darling, Eric (Reader)
Reineke, Joshua (Reader)
Brown University. Biology and Medicine: Artificial Organs, Biomaterials, and Cell Technology (sponsor)
Genre:
theses
Subject:
morphology
Biotechnology
Polymers
Polymer Films
Collection:
Biology and Medicine
Artificial Organs, Biomaterials, and Cell Technology
Theses and Dissertations
Full Record

Effects of Processing and Drug Loading on Morphology and Drug Release in PCL–Rifampicin Systems

Description:
This study examines how processing conditions regulate polymer morphology and mesophase formation in poly(caprolactone) (PCL) and how these structural transitions govern rifampicin release behavior. Demonstrating …
Year:
2026
Contributor:
George, Susan (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Jong, Yong (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Drug delivery systems
mesophase
biodegradable polymers
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Full Record

Engineering Double-Walled Nanospheres for More Effective Oral Drug Delivery: Quantitative Analysis of Uptake, Biodistribution, Bioadhesion and Nanoencapsulation

Description:
The field of medicine relies heavily on the use of therapeutic agents for the treatment of various illnesses but many of these drugs have chemical …
Year:
2012
Contributor:
Cho, Daniel Y (creator)
Mathiowitz, Edith (Director)
Morgan, Jeffrey (Reader)
Darling, Eric (Reader)
Palmore, G. Tayhas (Reader)
Zielinski, Beth (Reader)
Brown University. BIOMED: Artificial Organs, Biomaterials, and Cell Technology (sponsor)
Genre:
theses
Subject:
drug delivery
polymer science
nanoencapsulation
Drug delivery systems
Language:
English
Collection:
Biology and Medicine
Artificial Organs, Biomaterials, and Cell Technology
Theses and Dissertations
Full Record

Establishment of the Yucatan Minipig as a Preclinical Animal Model for Carpal Instabilities in the Human Wrist

Description:
Abstract of Establishment of the Yucatan Minipig as a Preclinical Animal Model for Carpal Instabilities in the Human Wrist, by Quianna Vaughan, Ph.D., Brown University, …
Year:
2026
Contributor:
Vaughan, Quianna (creator)
Crisco, Joseph (Advisor)
Darling, Eric (Reader)
Fleming, Braden (Reader)
Kesari, Haneesh (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Osteoarthritis
Arthroplasty
Yucatan minipig
Preclinical Animal Model
Human Wrist
Carpal Bone Replacement
Ligament Injury
Multidirectional Biomechanics
Osteophytes
Joint Space
Histology
Spatiotemporal Gait
Cartilage Damage
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Evaluating the Diffusive Capabilities of Polymeric Nanoparticles in Mucosal Environments

Description:
Oral drug delivery is a preferred route of administration for medication due to convenience and accessibility. However, due to enzymatic degradation in the gastrointestinal (GI) …
Year:
2025
Contributor:
Haque, Hena Mariam (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Shukla, Anita (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Nanoparticles
Oral Drug Delivery
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Evidence for Fibroblast-Directed Extracellular Matrix Remodeling Independent of Immune System Influence in a 3D Ring Microtissue Model

Description:
Human tissue regeneration is often characterized by the over-deposition of collagen, resulting in fibrotic scarring. Traditional research into wound healing and fibrosis relies heavily on …
Year:
2024
Contributor:
Marx, Madeleine Claire (creator)
Morgan, Jeffrey (Advisor)
Darling, Eric (Reader)
Coulombe, Kareen (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
tissue engineering
Regeneration (Biology)
Extracellular matrix
Extracellular Matrix Remodeling
Tissue regeneration
Wound healing
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Full Record

Gilding the Thread of Life: Proposing a Polymeric Drug Delivery System for Sustained Therapeutic Administration of Klotho Proteins

Description:
In the past 125 years, socio-economic developments and advancements in medicine and healthcare systems have contributed to a more than doubling of global human life …
Year:
2026
Contributor:
Keuning, Floor (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Jong, Yong (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Polymeric drug delivery systems
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Items (1-20) out of 48 results